Disposition and Renal Clearance of Propofol and its Glucuronide Metabolites after a Short Intravenous Infusion of Propofol

Vree, T. B.; Grood, P.M.R.M. de; Beem, H.B.H. van; Booij, L.H.D.J.

doi:10.2165/00044011-199713030-00004

Cited by 7 publications

(3 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In all cases molecular ions were observed. Two compounds have already been well described in previous studies and correspond to 2,6‐diisopropyl‐1,4‐quinol (denoted: 1,4‐quinol) and to 2,6‐diisopropyl‐1,4‐quinone (denoted: 1,4‐quinone) 5–9. The identification of these two peaks was confirmed by comparison of their mass spectra with those of authentic compounds.…”

Section: Resultssupporting

confidence: 62%

Detection of new propofol metabolites in human urine using gas chromatography/mass spectrometry and liquid chromatography/mass spectrometry techniques

Favetta¹,

Dufresne²,

Désage³

et al. 2000

Rapid Commun. Mass Spectrom.

View full text Add to dashboard Cite

Section: Resultssupporting

confidence: 62%

Detection of new propofol metabolites in human urine using gas chromatography/mass spectrometry and liquid chromatography/mass spectrometry techniques

Favetta¹,

Dufresne²,

Désage³

et al. 2000

Rapid Commun. Mass Spectrom.

View full text Add to dashboard Cite

“…Propofol is mainly eliminated (73% of the dose in 24 h and 88% in 120 h) by glomerular filtration (renal clearance of 120 ml/min) as water-soluble metabolites and/or bile [ 108 , 109 ]. Less than 1% of propofol is excreted unchanged in urine, and clearance is reduced in renal failure; only 2% is excreted in feces up to 48 h after dose [ 109 , 110 ]. In humans, the major metabolite in urine is the glucuronic acid conjugate of propofol, which accounts for 53–73% of the total metabolites, depending mainly on the administered dose of propofol [ 111 ].…”

Section: Pharmacokinetics Of Propofolmentioning

confidence: 99%

Metabolic Profiles of Propofol and Fospropofol: Clinical and Forensic Interpretative Aspects

Dinis-Oliveira

2018

BioMed Research International

View full text Add to dashboard Cite

Propofol is an intravenous short-acting anesthetic widely used to induce and maintain general anesthesia and to provide procedural sedation. The potential for propofol dependency and abuse has been recognized, and several cases of accidental overdose and suicide have emerged, mostly among the health professionals. Different studies have demonstrated an unpredictable interindividual variability of propofol pharmacokinetics and pharmacodynamics with forensic and clinical adverse relevant outcomes (e.g., pronounced respiratory and cardiac depression), namely, due to polymorphisms in the UDP-glucuronosyltransferase and cytochrome P450 isoforms and drugs administered concurrently. In this work the pharmacokinetics of propofol and fospropofol with particular focus on metabolic pathways is fully reviewed. It is concluded that knowing the metabolism of propofol may lead to the development of new clues to help further toxicological and clinical interpretations and to reduce serious adverse reactions such as respiratory failure, metabolic acidosis, rhabdomyolysis, cardiac bradyarrhythmias, hypotension and myocardial failure, anaphylaxis, hypertriglyceridemia, renal failure, hepatomegaly, hepatic steatosis, acute pancreatitis, abuse, and death. Particularly, further studies aiming to characterize polymorphic enzymes involved in the metabolic pathway, the development of additional routine forensic toxicological analysis, and the relatively new field of ‘‘omics” technology, namely, metabolomics, can offer more in explaining the unpredictable interindividual variability.

show abstract

“…From an intraoperative perspective, dexmedetomidine has been effectively used as a sedative for both awake craniotomy and sedation cases [114][115][116][117]. Some evidence suggests prolonged cognitive deficits may persist beyond the sedative action of the drug [116].…”

Section: Rationale For Icu Use and Adverse Reactionsmentioning

confidence: 99%

Critical care sedation for neuroscience patients

Mirski

Hemstreet

2007

Journal of the Neurological Sciences

View full text Add to dashboard Cite

Disposition and Renal Clearance of Propofol and its Glucuronide Metabolites after a Short Intravenous Infusion of Propofol

Cited by 7 publications

References 16 publications

Detection of new propofol metabolites in human urine using gas chromatography/mass spectrometry and liquid chromatography/mass spectrometry techniques

Detection of new propofol metabolites in human urine using gas chromatography/mass spectrometry and liquid chromatography/mass spectrometry techniques

Metabolic Profiles of Propofol and Fospropofol: Clinical and Forensic Interpretative Aspects

Critical care sedation for neuroscience patients

Contact Info

Product

Resources

About