Disposition and nephrotoxicity of 3-amino-1-hydroxypropylidene-1, 1-bisphosphonate (APD), in rats and mice

Acute Renal Effects of Intravenous Bisphosphonates in the Rat

“…Similarly, a previous study with a single dose of intravenous ibandronate and zoledronate (1 mg/kg, and 1 or 3 mg/kg, respectively) in 34-week old rats showed that 4 days after dosing there was no significant change in the majority of biochemical parameters and urinary enzymes compared with controls (Pfister et al 2003). Conversely, immediate changes in renal function have been reported for pamidronate and zoledronate in an acute renal tolerability model in the rat (Cal & Daley-Yates 1990;Green et al 1997). However, considering the delayed onset of structural changes with all three bisphosphonates in our studies, it is likely that these early effects are due to functional changes rather than to acute tubular injury.…”

Acute Renal Effects of Intravenous Bisphosphonates in the Rat

“…Similarly, a previous study with a single dose of intravenous ibandronate and zoledronate (1 mg/kg, and 1 or 3 mg/kg, respectively) in 34-week old rats showed that 4 days after dosing there was no significant change in the majority of biochemical parameters and urinary enzymes compared with controls (Pfister et al 2003). Conversely, immediate changes in renal function have been reported for pamidronate and zoledronate in an acute renal tolerability model in the rat (Cal & Daley-Yates 1990;Green et al 1997). However, considering the delayed onset of structural changes with all three bisphosphonates in our studies, it is likely that these early effects are due to functional changes rather than to acute tubular injury.…”

The role of vitamin E in the prevention of zoledronic acid-induced nephrotoxicity in rats: a light and electron microscopy study

“…Nephrotoxicity is a well-known side effect of bisphosphonates, and renal failure after rapid i.v. administration has been observed in both animals and humans [ 21 – 23 ]. In animal studies, reduced excretion and high concentration of bisphosphonates have been associated with proteinuria and proximal tubular necrosis [ 20 , 24 ].…”

Nephrotic proteinuria associated with high‐dose pamidronate in multiple myeloma

“…This same process may be responsible for the podocyte abnormalities observed in pamidronate nephrotoxicity (Markowitz et al, 2001). The dose effect is critical; increased pamidronate dose has been associated with non‐linear excretion, increased accumulation in kidneys and proximal tubular damage in animal models (Cal & Daley‐Yates, 1999).…”

Acute Renal Effects of Intravenous Bisphosphonates in the Rat

“…Similarly, a previous study with a single dose of intravenous ibandronate and zoledronate (1 mg/kg, and 1 or 3 mg/kg, respectively) in 34-week old rats showed that 4 days after dosing there was no significant change in the majority of biochemical parameters and urinary enzymes compared with controls (Pfister et al 2003). Conversely, immediate changes in renal function have been reported for pamidronate and zoledronate in an acute renal tolerability model in the rat (Cal & Daley-Yates 1990;Green et al 1997). However, considering the delayed onset of structural changes with all three bisphosphonates in our studies, it is likely that these early effects are due to functional changes rather than to acute tubular injury.…”

The role of vitamin E in the prevention of zoledronic acid-induced nephrotoxicity in rats: a light and electron microscopy study

“…Nephrotoxicity is a well-known side effect of bisphosphonates, and renal failure after rapid i.v. administration has been observed in both animals and humans [ 21 – 23 ]. In animal studies, reduced excretion and high concentration of bisphosphonates have been associated with proteinuria and proximal tubular necrosis [ 20 , 24 ].…”

Nephrotic proteinuria associated with high‐dose pamidronate in multiple myeloma

“…This same process may be responsible for the podocyte abnormalities observed in pamidronate nephrotoxicity (Markowitz et al, 2001). The dose effect is critical; increased pamidronate dose has been associated with non‐linear excretion, increased accumulation in kidneys and proximal tubular damage in animal models (Cal & Daley‐Yates, 1999).…”

Acute Renal Effects of Intravenous Bisphosphonates in the Rat

“…Similarly, a previous study with a single dose of intravenous ibandronate and zoledronate (1 mg/kg, and 1 or 3 mg/kg, respectively) in 34-week old rats showed that 4 days after dosing there was no significant change in the majority of biochemical parameters and urinary enzymes compared with controls (Pfister et al 2003). Conversely, immediate changes in renal function have been reported for pamidronate and zoledronate in an acute renal tolerability model in the rat (Cal & Daley-Yates 1990;Green et al 1997). However, considering the delayed onset of structural changes with all three bisphosphonates in our studies, it is likely that these early effects are due to functional changes rather than to acute tubular injury.…”

The role of vitamin E in the prevention of zoledronic acid-induced nephrotoxicity in rats: a light and electron microscopy study

“…Nephrotoxicity is a well-known side effect of bisphosphonates, and renal failure after rapid i.v. administration has been observed in both animals and humans [ 21 – 23 ]. In animal studies, reduced excretion and high concentration of bisphosphonates have been associated with proteinuria and proximal tubular necrosis [ 20 , 24 ].…”

Nephrotic proteinuria associated with high‐dose pamidronate in multiple myeloma

“…This same process may be responsible for the podocyte abnormalities observed in pamidronate nephrotoxicity (Markowitz et al, 2001). The dose effect is critical; increased pamidronate dose has been associated with non‐linear excretion, increased accumulation in kidneys and proximal tubular damage in animal models (Cal & Daley‐Yates, 1999).…”