Disposition and Biocompatibility of Dextrin-coated Cadmium Sulphide Nanoparticles after a Single Dose and Multiple Doses in Rats

Abstract

The development of nanomaterials has increased dramatically during the past decade [1] . However, currently only very few studies focus on the disposition of nanomaterials in vivo as well as the time taken to completely eliminate them in the organisms [2,3] . Researchers intended to study nanomaterial biocompatibility need to understand what happens to these after administered to living organisms. Predicting disposition of a nanomaterial is very important in the process of developing new nanomaterials for theranostic use in human beings [4] . All preclinical studies on nanomaterials should require a pharmacokinetic study in order to predict and understand the disposition once the nanomaterial enters the organism, when it is finally completely eliminated, and how safe its use is overall. The fate and disposition of any nanomaterial should be based on its properties, site of administration, formulation, and dosage [5] . For this reason, it is necessary to explore biocompatibility, tolerance and characterize the pharmacokinetic profile of each synthetized nanomaterial.An important parameter to consider in pharmacokinetic studies is the estimated mean time a drug resides in the body within specific tissues; the mean residence time (MRT) can help assess the extent of its efficacy and

New insights into the safety assessment of quantum dots: potential release pathways, environmental transformations, and health risks

“…At the cellular level, normal forms of inflammation are productive, while excessive inflammation can lead to cell death. Studies have shown that QDs can cause inflammatory reactions in the liver, 201,203,321,322 kidney, 323,324 and lung, [325][326][327] which is related to the mode of contact with QDs. QDs entering the body can also cross the blood-brain barrier and enter the nervous system to trigger an inflammatory reaction of neuromicroglia.…”