Disposable PDMS Chip With Integrated [¹⁸F]Fluoride Pre-Concentration Cartridge for Radiopharmaceuticals

Automated concentration of [18F]fluoride into microliter volumes

“…This straightforward approach is suitable for modest starting volumes, but may require impractically large chip real estate, or take too much time for sequential 200 µL evaporations to handle volumes in the 1–5 mL range that are expected from most cyclotrons. Another approach is to use miniature anion exchange cartridges to trap [ 18 F]fluoride from the large volume of [ 18 O]H 2 O and to then recover this [ 18 F]fluoride in smaller volumes ranging from 5 – 500 µL (De Leonardis et al, 2011; Elizarov et al, 2010; Lebedev et al, 2012; Salvador et al, 2017). Elizarov et al demonstrated concentration of 32.4 GBq [876 mCi] of [ 18 F]fluoride with a starting volume of 2 mL to a final volume of 5 μL within a custom-built micro cartridge with 2 µL bed volume filled with AG-1-X8 QMA resin (Bio-Rad Laboratories, Inc., USA) (Elizarov et al, 2010).…”

“…Of various eluents tested, CaCO 3 performed the best, recovering 94 ± 6% (n=2) of the activity in a volume of 100 μL. Recently, Salvador et al demonstrated concentration of [ 18 F]fluoride within a manually-operated custom built PDMS microfluidic system with 10–15 mg embedded QMA resin (from Sep-Pak Accell Plus cartridge, Waters, Inc., USA) (Salvador et al, 2017). For activities of 19 GBq [0.5 Ci], trapping of 2 mL of [ 18 F]fluoride in [ 18 O]H 2 O was achieved with 98% efficiency; trapped activity could then be eluted into a volume of 20 μL with >87% recovery.…”

Implementation of iMiDEV™, a new fully automated microfluidic platform for radiopharmaceutical production

“…23 However, some progress has been achieved in the development of the fluoride-18 and gallium-68 concentration systems adapted or integrated into microfluidic cassettes. [24][25][26][27][28][29] Recently, a new custom platform that can perform steps starting from radionuclide concentration and finishing with purification of the final product has been shown to successfully produce a [ 18 F] fallypride dose. 19 Nevertheless, fabrication and industrialisation of a fully integrated on-chip platform remains an engineering challenge of great interest.…”