Disposable Electrochemical Biosensor to Monitor Factor-Xa Inhibitors at the Point-of-Care Anticoagulation Therapy

Mruthunjaya, Ashwin K. V.; Chatelier, Ronald C.; Torriero, Angel A. J.

doi:10.2139/ssrn.4516211

Cited by 3 publications

(2 citation statements)

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“…Similarly to the case of thrombin, monitoring FXa activity is another viable method for quantifying anticoagulants. This was confirmed by our group, where using a disposable gold cofacing recycling electrode system, an FXa enzyme-based point-of-care assay was demonstrated for DOACs involving rivaroxaban, edoxaban and LMWHs, such as enoxaparin and dalteparin [58]. The working principle of this sensor is similar to that described in Figure 3.…”

Section: Electrochemical Sensors For Anticoagulants Using Thrombin-sp...supporting

confidence: 65%

“…The complexity escalates further when patients are unconscious and their anticoagulation status remains uncertain. To address this issue, recently, we explored the possibility of replacing individual drug-specific calibrations with a single calibration plot set for DOACs and one for LMWHs, which could quantify inhibitors belonging to the DOACs family (rivaroxaban and edoxaban) and LMWHs family (enoxaparin and dalteparin) respectively [58]. The result suggests that the sensor can detect and quantify rivaroxaban and edoxaban without a calibration plot or a universal calibration plot.…”

Section: Common Calibration Methodsmentioning

confidence: 99%

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Electrochemical Monitoring on Anticoagulation Therapy

Mruthunjaya,

Torriero

2024

Preprint

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The process of blood coagulation, wherein circulating blood transforms into a clot in response to internal or external injury, is a critical physiological mechanism. Monitoring this coagulation process is vital to ensure that blood clotting occurs neither too rapidly nor too slowly. Anticoagulants, a category of medications designed to prevent and treat blood clots, require meticulous monitoring to optimise dosage, enhance clinical outcomes, and minimise adverse effects. This review article delves into the various stages of blood coagulation, explores commonly used anticoagulants and their targets within the coagulation enzyme system, and emphasises the electrochemical methods employed in anticoagulant testing. Electrochemical sensors for anticoagulant monitoring are categorised into two types. The first type focuses on assays measuring thrombin activity via electrochemical techniques. The second type involves modified electrode surfaces that either directly measure the redox behaviour of anticoagulants or monitor the response of standard redox probes in the presence of these drugs. The review provides a comprehensive list of different electrode compositions and their detection and quantification limits. Additionally, it discusses the potential of employing a universal calibration plot to replace individual drug-specific calibrations. The insights presented are anticipated to significantly contribute to the sensor community's efforts in this field.

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Section: Electrochemical Sensors For Anticoagulants Using Thrombin-sp...supporting

confidence: 65%

Section: Common Calibration Methodsmentioning

confidence: 99%

Electrochemical Monitoring on Anticoagulation Therapy

Mruthunjaya,

Torriero

2024

Preprint

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Effect of Hydrogen Plasma Treatment on the Sensitivity of ZnO Based Electrochemical Non-Enzymatic Biosensor

et al. 2023

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Information on vitamin C—ascorbic acid (AA)—content is important as it facilitates the provision of dietary advice and strategies for the prevention and treatment of conditions associated with AA deficiency or excess. The methods of determining AA content include chromatographic techniques, spectrophotometry, and electrochemical methods of analysis. In the present work, an electrochemical enzyme-free ascorbic acid sensor for a neutral medium has been developed. The sensor is based on zinc oxide nanowire (ZnO NW) arrays synthesized via low-temperature chemical deposition (Chemical Bath Deposition) on the surface of an ITO substrate. The sensitivity of the electrochemical enzyme-free sensor was found to be dependent on the process treatments. The AA sensitivity values measured in a neutral PBS electrolyte were found to be 73, 44, and 92 µA mM−1 cm−2 for the ZnO NW-based sensors of the pristine, air-annealed (AT), and air-annealed followed by hydrogen plasma treatment (AT+PT), respectively. The simple H-plasma treatment of ZnO nanowire arrays synthesized via low-temperature chemical deposition has been shown to be an effective process step to produce an enzyme-free sensor for biological molecules in a neutral electrolyte for applications in health care and biomedical safety.

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Electrochemical Monitoring in Anticoagulation Therapy

Mruthunjaya,

Torriero

2024

Molecules

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The process of blood coagulation, wherein circulating blood transforms into a clot in response to an internal or external injury, is a critical physiological mechanism. Monitoring this coagulation process is vital to ensure that blood clotting neither occurs too rapidly nor too slowly. Anticoagulants, a category of medications designed to prevent and treat blood clots, require meticulous monitoring to optimise dosage, enhance clinical outcomes, and minimise adverse effects. This review article delves into the various stages of blood coagulation, explores commonly used anticoagulants and their targets within the coagulation enzyme system, and emphasises the electrochemical methods employed in anticoagulant testing. Electrochemical sensors for anticoagulant monitoring are categorised into two types. The first type focuses on assays measuring thrombin activity via electrochemical techniques. The second type involves modified electrode surfaces that either directly measure the redox behaviours of anticoagulants or monitor the responses of standard redox probes in the presence of these drugs. This review comprehensively lists different electrode compositions and their detection and quantification limits. Additionally, it discusses the potential of employing a universal calibration plot to replace individual drug-specific calibrations. The presented insights are anticipated to significantly contribute to the sensor community’s efforts in this field.

show abstract

Disposable Electrochemical Biosensor to Monitor Factor-Xa Inhibitors at the Point-of-Care Anticoagulation Therapy

Cited by 3 publications

References 0 publications

Electrochemical Monitoring on Anticoagulation Therapy

Electrochemical Monitoring on Anticoagulation Therapy

Effect of Hydrogen Plasma Treatment on the Sensitivity of ZnO Based Electrochemical Non-Enzymatic Biosensor

Electrochemical Monitoring in Anticoagulation Therapy

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