Displays of 18F-FAPI PET/CT in Myocarditis With Variable Symptom Durations

Abstract

We report cardiac 18F-FAPI PET/CT findings in 3 cases with myocarditis of varying duration (7 hours, 1 week, and 1 month). Myocarditis with varying symptom durations showed different 18F-FAPI uptake, suggesting that the 18F-FAPI PET/CT may be helpful in evaluating the extent of fibrosis caused by myocarditis. This information may assist in treatment decision-making for patients with myocarditis.

99mTc-PYP and 68Ga-FAPI PET/CT Images of Hereditary Transthyretin Amyloidosis With Cardiac Involvement

“…FAPI uptake was shown in cardiac diseases including mural thrombus, myocarditis, and cardiomyopathy. [5][6][7][8] FAPI PET can be useful as a diagnostic marker in cardiac sarcoidosis in FDG PET-negative patients, and in light chain amyloidosis with cardiac involvement, increased FAPI uptake was shown recently. [9][10][11] To our knowledge, this is the first case of a patient with hereditary transthyretin amyloidosis with cardiac involvement, which FAPI PET showed diffuse increased myocardial uptake.…”

“…FAPI is a more recent radiotracer, which can show fibroblast activation. FAPI uptake was shown in cardiac diseases including mural thrombus, myocarditis, and cardiomyopathy 5–8 . FAPI PET can be useful as a diagnostic marker in cardiac sarcoidosis in FDG PET-negative patients, and in light chain amyloidosis with cardiac involvement, increased FAPI uptake was shown recently 9–11 .…”

Intense 68Ga-OncoFAP Uptake as a New Promising Diagnostic Biomarker in Cardiac Sarcoidosis

“…However, as in the case report presented here, a negative 18 F-FDG PET scan may indicate the absence or minimal inflammatory activity, underscoring the need for new markers to identify active CS. Radiolabeled fibroblast activation protein (FAP) inhibitors were originally developed for the imaging of various tumors but has recently attracted interest for other applications such as the imaging of inflammation and remodeling to fibrosis 7–9 . FAP is overexpressed in granulomas, as demonstrated by immunohistopathologic studies 10 .…”