Dispersive solid‐phase extraction of risperidone from plasma samples using graphene oxide aerogels and determination with liquid chromatography

Abstract

A graphene oxide‐based aerogel was synthesized and applied to the extraction and the determinations with the high‐performance liquid chromatography‐ultraviolet detector. After the characterization of the produced graphene‐aerogel, it was utilized as a dispersive solid‐phase extraction sorbent for risperidone extraction from plasma samples. Aerogels are materials with a large surface area‐to‐mass ratio and plenty of core with functional groups which can easily attach to the analytes to extract them to the second phase. The suggested method determined risperidone in plasma samples in the wide dynamic range from 20 ng/ml to 3 μg/ml. The limits of detection and quantification of the developed method were calculated as 2.4 and 8.2 ng/ml, respectively. As a novel feature, the developed method has no need to precipitate plasma proteins, improving the analytical performance of the analysis. Also, for the first time, the produced materials were utilized for the extraction of risperidone from the plasma samples. The obtained results revealed that the developed approach could be employed as an accurate method for the quantification of risperidone in real plasma samples.

Individual and Simultaneous Electrochemical Detection of Allura Red and Acid Blue 9 in Food Samples Using a Novel La2YCrO6 Double Perovskite Decorated on HLNTs as an Electrocatalyst

“…In this regard, it is required to develop reliable analytical methods that allow the detection of AR and AB in different biological fluids at broad therapeutic concentrations. Several methods were employed for AR and AB analysis in different media based on different techniques such as spectrophotometric methods, HPLC, electrochemical methods, chemiluminescence, etc. − Electrochemical sensing is a potential technology for detecting small quantities of chemicals that has a few advantages. As a result, developing novel sensor materials with electrocatalyst capabilities that can enhance existing electrodes is essential .…”