Dispersive liquid–liquid microextraction combined with field-amplified sample stacking in capillary electrophoresis for the determination of non-steroidal anti-inflammatory drugs in milk and dairy products

Alshana, Usama; Göǧer, Nilgün Günden; Ertaş, Nusret

doi:10.1016/j.foodchem.2012.11.121

Cited by 68 publications

(22 citation statements)

References 31 publications

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“…From these points of view different DLLME using organic solvent or ionic liquids have been developed for the extraction of NSAIDs from different liquid samples. The main disadvantage of these methods is the difficulty of taking out the small amount of extraction solvent and some water may be transferred into the syringe .…”

Section: Introductionmentioning

confidence: 99%

Determination of four acidic nonsteroidal anti‐inflammatory drugs in wastewater samples by dispersive liquid–liquid microextraction based on solidification of floating organic droplet and high‐performance liquid chromatography

Beldean‐Galea

Coman

Thiébaut

et al. 2015

J of Separation Science

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A simple, environmentally friendly, and sensitive dispersive liquid-liquid microextraction based on solidification of floating organic droplet for the extraction of four acidic nonsteroidal anti-inflammatory drugs (ketoprofen, naproxen, ibuprofen, and diclofenac) from wastewater samples subsequent by high-performance liquid chromatography analysis was developed. The influence of extraction parameters such as pH, the effect of solution ionic strength, type of extraction solvent, disperser solvent, and extraction solvent volume were studied. High enrichment factors (283-302) were obtained through the developed method. The method provides good linearity (r > 0.999) in a concentration range of 1-100 μg/L, good intra- and inter-day precision (relative standard deviation < 7%) and low limits of quantification. The relative recoveries of the selected compounds were situated over 80% both in synthetic and real water samples. The developed method has been successfully applied for the analysis of the selected compounds in wastewater samples.

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Section: Introductionmentioning

confidence: 99%

Determination of four acidic nonsteroidal anti‐inflammatory drugs in wastewater samples by dispersive liquid–liquid microextraction based on solidification of floating organic droplet and high‐performance liquid chromatography

Beldean‐Galea

Coman

Thiébaut

et al. 2015

J of Separation Science

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“…Consequently, a considerable amount of these drugs is poured into the environment from many different sources. The problem becomes of public health concern, as well as environmental, starting from the moment these compounds enter into aquifers and foodstuffs [53,[66][67][68]. The method described so far was intended to enable us to draw conclusions about the presence of the 14 selected NSAIDs in the environment.…”

Section: Discussionmentioning

confidence: 99%

Occurrence of non-steroidal anti-inflammatory drugs in surface waters of Central Italy by liquid chromatography–tandem mass spectrometry

Rocca

Gentili

Caretti

et al. 2015

International Journal of Environmental Analytical Chemistry

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Non-steroidal anti-inflammatory drugs (NSAIDs) are considered to be the cure-all of any pain: from headache and cold symptoms to toothaches and even labour pain. Their wide use in human medicine has been favoured by the possibility to purchase them without medical prescription, their low cost and by the absence of opioid-like side effects. At the same time, their administration to domestic and food-producing animals has become a common practice to improve their well-being. Therefore, human and veterinary applications are the main sources of NSAIDs in the environment and the major pathways are excretion and discharge through sewage treatment plants. Although their environmental occurrence is well-known, there is a lack of data regarding their levels in surface waters of Central Italy. In this study, a monitoring campaign was arranged in some of the most important rivers and lakes of Central Italy, characterised by a different anthropic impact, in spring-summer and autumn-winter 2012. A broad range of NSAIDs for human and animal use was analysed through a reliable analytical method based on liquid chromatography-tandem mass spectrometry, appropriately developed and validated. Results have shown the constant presence of all drugs commonly used in human medicine with a composition that mirrored the incidence of seasonal diseases quite well. A veterinary drug (flunixin) was found in Bracciano Lake (Rome district), an important tourist attraction surrounded by farmlands. Salicylic acid is a phytohormone and this explains its presence in all the analyzed samples. All the results collected during the extensive survey have proved that Central Italy is aligned with the rest of Europe since its natural waters have shown low levels of contamination (ngL(-1)) but with a chronic input

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“…Dispersive liquid–liquid microextraction (DLLME), which is another LPME mode, has been widely employed for food analysis . In the case of milk or its derivatives, different methodologies have been proposed for the extraction of diverse analytes as, for example, antibiotics polybrominated diphenyl ethers , cholesterol nonsteroidal anti‐inflammatory drugs , etc. However, up to now, this technique has not been employed for the determination of estrogenic hormones in these matrices.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the combination of a dispersive liquid–liquid microextraction method with micellar electrokinetic chromatography coupled to mass spectrometry for the determination of estrogenic compounds in milk and yogurt

et al. 2015

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In this work, the suitability of a methodology based on dispersive liquid-liquid microextraction (DLLME) has been evaluated for the extraction of four endoestrogens (estriol, 17α-estradiol, 17β-estradiol, and estrone), an exoestrogen (17α-etynylestradiol), and a mycotoxin (zearalenone), together with some of their major metabolites (2-methoxyestradiol, α-zearalanol, β-zearalanol, α-zearalenol, and β-zearalenol) from different types of milk (whole and skimmed cow milk and semiskimmed goat milk) and whole natural yogurt. The methodology includes a previous protein precipitation with acidified ACN and a defatting step with n-hexane. Separation of the analytes, determination, and quantification were developed by MEKC coupled to ESI-MS using a BGE containing an aqueous solution of ammonium perfluorooctanoate as MS friendly surfactant. Calibration, precision, and accuracy studies of the described DLLME-MEKC-MS/MS method were evaluated obtaining a good linearity and LODs in the low micrograms per liter range.

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Dispersive liquid–liquid microextraction combined with field-amplified sample stacking in capillary electrophoresis for the determination of non-steroidal anti-inflammatory drugs in milk and dairy products

Cited by 68 publications

References 31 publications

Determination of four acidic nonsteroidal anti‐inflammatory drugs in wastewater samples by dispersive liquid–liquid microextraction based on solidification of floating organic droplet and high‐performance liquid chromatography

Determination of four acidic nonsteroidal anti‐inflammatory drugs in wastewater samples by dispersive liquid–liquid microextraction based on solidification of floating organic droplet and high‐performance liquid chromatography

Occurrence of non-steroidal anti-inflammatory drugs in surface waters of Central Italy by liquid chromatography–tandem mass spectrometry

Evaluation of the combination of a dispersive liquid–liquid microextraction method with micellar electrokinetic chromatography coupled to mass spectrometry for the determination of estrogenic compounds in milk and yogurt

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