Dispersion stability and biocompatibility of four ligand-exchanged NaYF4: Yb, Er upconversion nanoparticles

Chen, Yinghui; D’Amario, Claudia; Gee, Alex; Duong, Hien T. T.; Shimoni, Olga; Valenzuela, Stella M.

doi:10.1016/j.actbio.2019.11.048

Cited by 46 publications

(21 citation statements)

References 37 publications

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“…Similar findings suggesting a partial blocking of the cell cycle by UCNPs were reported by Liu et al, who also observed a G0/G1 cellcycle arrest and a significant decrease of the PI for human gastric adenocarcinoma (SGC-7901) cells incubated with poly(N-vinylpyrrolidone) (PVP)-coated NaYF 4 :Yb,Er particles in a similar concentration range [74]. Chen et al investigated NaYF 4 :Yb,Er nanoparticles capped with (aminomethyl)phosphonic (AMPA), (aminopropyl)triethoxysilane (APTES), and dihydrocinnamic acid (DHCA) on epithelial cells (Chinese hamster ovary cells, CHO-K1) [75]. They observed that the positively charged AMPA and APTES UCNPs, as well as the negatively charged DHCA-capped particles led to a severe dysregulation of the cell cycle.…”

Section: Cell Cycle Analysismentioning

confidence: 99%

Effect of different silica coatings on the toxicity of upconversion nanoparticles on RAW 264.7 macrophage cells

Kembuan¹,

Oliveira²,

Gräf³

2021

Beilstein J. Nanotechnol.

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Upconversion nanoparticles (UCNPs), consisting of NaYF4 doped with 18% Yb and 2% Er, were coated with microporous silica shells with thickness values of 7 ± 2 and 21 ± 3 nm. Subsequently, the negatively charged particles were functionalized with N-(6-aminohexyl)-3-aminopropyltrimethoxysilane (AHAPS), which provide a positive charge to the nanoparticle surface. Inductively coupled plasma optical emission spectrometry (ICP-OES) measurements revealed that, over the course of 24h, particles with thicker shells release fewer lanthanide ions than particles with thinner shells. However, even a 21 ± 3 nm thick silica layer does not entirely block the disintegration process of the UCNPs. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays and cell cytometry measurements performed on macrophages (RAW 264.7 cells) indicate that cells treated with amino-functionalized particles with a thicker silica shell have a higher viability than those incubated with UCNPs with a thinner silica shell, even if more particles with a thicker shell are taken up. This effect is less significant for negatively charged particles. Cell cycle analyses with amino-functionalized particles also confirm that thicker silica shells reduce cytotoxicity. Thus, growing silica shells to a sufficient thickness is a simple approach to minimize the cytotoxicity of UCNPs.

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Section: Cell Cycle Analysismentioning

confidence: 99%

Effect of different silica coatings on the toxicity of upconversion nanoparticles on RAW 264.7 macrophage cells

Kembuan¹,

Oliveira²,

Gräf³

2021

Beilstein J. Nanotechnol.

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“…Таким образом, одной из важнейших проблем, стоящих перед использованием гидрофобных наночастиц для биомедицинских приложений, является модификация и функционализация их поверхности для улучшения водорастворимости и обеспечения наличия реакционноспособных групп для последующего биоконъюгирования. В последние годы для решения этой задачи было разработано множество технологий модификации: методы обмена или окисления лигандов, технология синтеза наночастиц без лигандов, использование амфифильных полимеров, метод электростатической послойной сборки и силанизация поверхности наночастиц [93,[118][119][120][121].…”

Section: поверхностная модификация наночастицunclassified

Люминесцентные Наноматериалы, Допированные Редкоземельными Ионами, И Перспективы Их Биомедицинского Применения (Обзор)

Бажукова¹,

Пустоваров²,

Мышкина³

et al. 2020

Журнал Технической Физики

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Luminescent nanomaterials doped with rare-earth elements are characterized by such physicochemical properties as long-lived luminescence, large Stokes or anti-Stokes shifts, narrow emission bands, high photostability and low toxicity. These materials can be considered as a new generation of biosensors along with conventional molecular probes, such as organic dyes, quantum dots and chelate-based lanthanide probes. In recent years there has been significant interest in the study of functional nanomaterials based on rare earth elements. The purpose of this paper is to provide an overview of recent advances in the development of luminescent inorganic nanoparticles doped with rare earth elements which could be used for biomedical applications.

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“…Lanthanide‐doped upconversion nanophosphors (UCNPs) materials have unique luminescence properties, such as the conversion of long‐wavelength near‐infrared (NIR) excitation into short‐wavelength visible emission. [ 1 ] UCNPs have been widely applied in various fields such as optical devices, [ 2,3 ] sensing, [ 4,5 ] 3D displays, [ 6 ] bio‐imaging, [ 7 ] and therapeutics. [ 8,9 ] In particular, UCNPs have been developed in biological fields for various applications that require low autofluorescence backgrounds, large anti‐Stokes’ shifts, sharp emission bandwidths, high resistance to photo‐bleaching, high penetration depth tissue, and high temporal resolution.…”

Section: Introductionmentioning

confidence: 99%

Improvement of luminescence properties of NaYF₄:Yb³⁺/Er³⁺ upconversion materials by a cross‐relaxation mechanism based on co‐doped Ho³⁺ ion concentrations

2021

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NaYF4:Yb3+/Er3+/Ho3+ nanophosphors were successfully synthesized using a solvothermal method and with various concentrations of Ho3+ ions. The crystal structure, grain size, morphology, and luminescence properties were analyzed by X‐ray diffraction, field‐emission scanning electron microscopy, and photoluminescence measurements. All samples were crystallized as a cubic structure; it was confirmed that all samples exhibited strong green emission and weak red emission generated at a particular level of the activated ions. The strongest upconversion fluorescence intensity was observed in the Ho3+ and Er3+ ions co‐doped NaYF4 materials with a Ho3+ ion concentration of 0.005 mol. Only the green fluorescence intensity at the 542 nm centre increased strongly due to the 4S3/2→4I15/2 energy transfer. This increase in upconversion fluorescence intensity at a selected wavelength was described as a cross‐relaxation mechanism due to the addition of Ho3+ ions.

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Dispersion stability and biocompatibility of four ligand-exchanged NaYF4: Yb, Er upconversion nanoparticles

Cited by 46 publications

References 37 publications

Effect of different silica coatings on the toxicity of upconversion nanoparticles on RAW 264.7 macrophage cells

Effect of different silica coatings on the toxicity of upconversion nanoparticles on RAW 264.7 macrophage cells

Люминесцентные Наноматериалы, Допированные Редкоземельными Ионами, И Перспективы Их Биомедицинского Применения (Обзор)

Improvement of luminescence properties of NaYF₄:Yb³⁺/Er³⁺ upconversion materials by a cross‐relaxation mechanism based on co‐doped Ho³⁺ ion concentrations

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Dispersion stability and biocompatibility of four ligand-exchanged NaYF4: Yb, Er upconversion nanoparticles

Cited by 46 publications

References 37 publications

Effect of different silica coatings on the toxicity of upconversion nanoparticles on RAW 264.7 macrophage cells

Effect of different silica coatings on the toxicity of upconversion nanoparticles on RAW 264.7 macrophage cells

Люминесцентные Наноматериалы, Допированные Редкоземельными Ионами, И Перспективы Их Биомедицинского Применения (Обзор)

Improvement of luminescence properties of NaYF4:Yb3+/Er3+ upconversion materials by a cross‐relaxation mechanism based on co‐doped Ho3+ ion concentrations

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Improvement of luminescence properties of NaYF₄:Yb³⁺/Er³⁺ upconversion materials by a cross‐relaxation mechanism based on co‐doped Ho³⁺ ion concentrations