Dispersion of ventricular repolarization in hypertrophic cardiomyopathy

Zaidi, M; Robert, Annie; Fesler, Robert; Derwael, C.; Brohet, Christian

doi:10.1016/s0022-0736(96)80026-4

Cited by 28 publications

(18 citation statements)

References 24 publications

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“…Both QT dispersion and corrected OT dispersion are accepted as an indicator of arrhythmic events and general abnormality of repolarization (20)(21)(22)(23). Therefore, the factors, which change QT dispersion might effect clinical presentation of the disease like HCMP and arrhythmic heart diseases.…”

Section: Discussionmentioning

confidence: 99%

The variations of BOP gene in hypertrophic cardiomyopathy

Abacı¹,

Güleç²,

Bayrak³

et al. 2010

Anadolu Kardiyol Derg

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Hipertrofik kardiyomiyopatide BOP geni varyasyonları 303ÖZET Amaç: Bop mutant farelerde, az gelişmiş sağ ventrikül ve aşırı büyümüş sol ventrikül varlığı, insan BOP geni ile hipertrofik kardiyomiyopati (HKMP) arasında olası bir ilişkiyi düşündürmektedir. Bu çalışmamızda, BOP genindeki varyasyonlar ile HKMP için noninvazif bir aritmik risk göstergesi olan QT dispersiyonu arasındaki olası ilişkiyi araştırdık. Yöntemler: Enine-kesitli niteliğindeki çalışmaya 50 HKMP'li hasta ve 60 sağlıklı kontrol alındı. BOP geni ekson bölgeleri, polimeraz zincir reaksiyonu (PCR) ile çoğaltıldı ve çoğaltılan ekson bölgeleri, Tek İplikli Konformasyon Polimorfizm (SSCP) analizi ile incelendi. Farklı bantlara sahip örnekler otomatik dizileme yöntemi kullanılarak dizilendi. Sürekli değişkenler eşleştirilmemiş bağımsız örneklem t-testi ya da Mann-Whitney U testi ile karşı-laştırıldı. Genotip-hastalık ilişkisi Ki-kare testi ile test edildi. Bulgular: Ekson 2 ve 7'deki G275>A ve C965>A tek nükleotid değişimleri (TND) sadece HK grubunda belirlendi. Ekson 6 ve 9'daki G707>C, C710>T, T761>C, T1217>C TND'lerine kontrol grubunda da rastlandı. İki grup arasındaki fark ise anlamlı bulundu (p=0.002 ve p<0.001). Ekzon 6'daki TND'lerin haplotip oluşturduğu ve bu haplotipin nadir alleli (707C/710T/761C) için homozigot taşıyıcı olan HK hastalarında QT dispersiyonu ve düzeltilmiş QT dispersiyonu, diğer genotiplere göre anlamlı derecede düşük bulundu (p=0.032 ve p=0.030). Sonuç: Bu çalışma, insanda BOP geni ile HKMP arasındaki ilişkiyi araştıran ilk çalışmadır. Üç farklı TND'yi içeren 707C/710T/761C haplotip takımını taşıyan HK'li olgularda QT dispersiyonu ve düzeltilmiş QT dispersiyonunun anlamlı derecede uzamış bulunması, BOP genindeki bu haplotipin ventikü-ler aritmilerle ve dolayısı ile ani ölümle ilişkili olabileceğini akla getirmektedir. (Anadolu Kardiyol Derg 2010; 10: 303-9) Anah tar ke li me ler: BOP, hipertrofik kardiyomiyopati, klinik farklılık, modifiye edici gen, genetik varyasyon, QT dispersiyonu ABSTRACT Objective: The observation that Bop null allele mice show underdeveloped right ventricle and excessive development of left ventricle, suggests the possible relationship between human BOP gene and hypertrophic cardiomyopathy (HCMP). In our study, we investigated this possible relationship between BOP gene variations and QT dispersion, a noninvasive arrhythmic risk marker for HCMP. Methods: This cross-sectional study consisted of 50 patients clinically diagnosed with HCMP and 60 healthy subjects. Exonic regions of BOP gene were amplified by polymerase chain reaction and amplified exonic regions were analyzed by Single-Strand Conformation Polymorphisms (SSCP). The samples with different migration patterns were sequenced through an automated sequencing system. Continuous variables were compared by unpaired t-test for independent samples or Mann-Whitney U test. Genotype-disease relationship was tested by Chi-square test. Results: The nucleotide substitutions G275>A and C965>A in exon 2 and 7 were determined only in HCMP group. The G707>C, C7...

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Section: Discussionmentioning

confidence: 99%

The variations of BOP gene in hypertrophic cardiomyopathy

Abacı¹,

Güleç²,

Bayrak³

et al. 2010

Anadolu Kardiyol Derg

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“…1, left panel). In accordance with previously published works [13,14,15,19,20,21], a single physician (M.C. ), blinded to patient characteristics, measured the QT e from the onset of the QRS complex to the end of the T wave and, when the latter was unclear, the QT interval was defined as the intersection of the isoelectric baseline and the maximum tangent line of the T wave terminal limb.…”

Section: Methodsmentioning

confidence: 99%

“…The Q-T end (QT e ) spatial dispersion on 12-lead surface electrocardiogram (ECG) is considered an easy and noninvasive index of dispersion of myocardial repolarization, the latter closely linked to the HCM arrhythmic risk [7,8,9,10,11,12,13,14,15]. However, a number of clinical variables, such as distribution and magnitude of ventricular hypertrophy and fibrosis, as well as LV dysfunction, might potentially alter this ECG-derived parameter, thus limiting its use in routine clinical practice [7,8,9,10,11].…”

Section: Introductionmentioning

confidence: 99%

Spatial QT Dispersion Predicts Nonsustained Ventricular Tachycardia and Correlates with Confined Systodiastolic Dysfunction in Hypertrophic Cardiomyopathy

Magrì

Piccirillo²,

Ricotta

et al. 2015

Cardiology

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Objectives: An increased dispersion of myocardial repolarization represents one of the mechanisms underlying the arrhythmic risk in hypertrophic cardiomyopathy (HCM). We investigated spatial myocardial repolarization dispersion indices in HCM patients with nonsustained ventricular tachycardia (NSVT) and, contextually, their main clinical determinants. Methods: Fifty-two well-matched HCM outpatients were categorized into two groups according to the presence or the absence of NSVT at 24-hour Holter electrocardiogram (ECG) monitoring. Each patient underwent a clinical examination, including Doppler echocardiogram integrated with tissue Doppler imaging, cardiac magnetic resonance, and 12-lead surface ECG to calculate the dispersion for the following intervals: QRS, Q-T_end (QT_e), Q-T_peak, T_peak-T_end (T_pT_e), J-T_peak, and J-T_end. Results: The NSVT group showed only QT_e dispersion and T_pT_e dispersion values to be significantly higher than their counterparts. NSVT occurrence was independently predicted by late gadolinium enhancement presence (p = 0.021) and QT_e Bazett dispersion (p = 0.030), the latter strongly associated with the myocardial performance index (MPI) obtained at the basal segment of the interventricular septum (p = 0.0004). Conclusion: Our data support QT_e dispersion as an easy and noninvasive tool for identifying HCM patients with NSVT propensity. The strong relationship between QT_e dispersion and MPI allows us to hypothesize an intriguing link between electrical instability and confined myocardial areas of systodiastolic dysfunction.

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“…M-mode, 2-D, Doppler and color flow Doppler echocardiographies were performed; serum electrolytes and glucose levels were measured and thyroid function tests were studied also in control subjects. Since the factors mentioned below cause significant QTd, subjects with left ventricular hypertrophy [17], heart failure [18], electrolyte imbalances [19], long QT syndrome [20], cardiomyopathy [21], hypothyroidism [22] and those who had been using any type of antiarrhythmic agent were excluded from the study. Finally, 53 patients with CHD and 57 control subjects with normal myocardial perfusion imaging and gated spect were incorporated into this study.…”

Section: Methodsmentioning

confidence: 99%

Weekly Variation of the QT Dispersion in Healthy Subjects and in Patients with Coronary Heart Disease

Oren

Cosgun

2006

Cardiology

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Background: A circadian and seasonal variation of QT dispersion (QTd) has been shown in healthy individuals. Nevertheless, no data exist regarding the weekly influences on the QTd in healthy individuals and in patients with coronary heart disease (CHD). Design: This study was designed to determine whether there is a weekly variability of QTd in healthy individuals and in patients with CHD. Methods: In this prospective registry study, 53 patients with documented CHD and 57 healthy control subjects were involved. Resting electrocardiograms (ECGs) with double amplitude were recorded at a speed of 50 mm/s on Monday and Friday mornings. QT intervals were measured and QTd were determined by calculating the difference between maximum and minimum QT intervals. Then, rate-corrected QTd (QTcd) were calculated using Bazett’s formula. Results: There was a significant weekly variation of QTd in control subjects (39.3 ± 6.3 vs. 36.2 ±6.1 ms) (p < 0.05) and in patients (56 ± 7.3 vs. 47.4 ± 5.4 ms) (p < 0.0001). There was also a significant weekly variation of QTcd both in control subjects (33 ± 5.3 vs. 30.7 ± 5.6 ms) (p < 0.05) and in patients (47.4 ± 6.4 vs. 41.9 ± 5.4 ms) (p < 0.0001). Conclusions: There is a weekly variation of QTd and QTcd in healthy individuals and in patients with CHD, both with a Monday preference. This fact should be taken into consideration during the chronopharmacological treatment or advisal of primary or secondary preventive measures to these subjects or patients.

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Dispersion of ventricular repolarization in hypertrophic cardiomyopathy

Cited by 28 publications

References 24 publications

The variations of BOP gene in hypertrophic cardiomyopathy

The variations of BOP gene in hypertrophic cardiomyopathy

Spatial QT Dispersion Predicts Nonsustained Ventricular Tachycardia and Correlates with Confined Systodiastolic Dysfunction in Hypertrophic Cardiomyopathy

Weekly Variation of the QT Dispersion in Healthy Subjects and in Patients with Coronary Heart Disease

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