Dispersion Durations of P-wave and QT Interval in Children With Congenital Heart Disease and Pulmonary Arterial Hypertension

Şap, Fatih; Karataş, Zehra; Altın, Hakan; Alp, Hayrullah; Oran, Bülent; Baysal, Tamer; Karaarslan, Sevim

doi:10.1007/s00246-012-0503-5

Cited by 18 publications

(7 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our study, PWD duration was found to be significantly prolonged in children with PAH-CHD than in CHD patients without PAH and Control group. This was concordant with other studies [12], [13] that reported increased PWD in patients with PAH-CHD relative to those without PAH and Control group. Moreover, a cutoff value of 32.5 ms of PWD was found to predict the occurrence of arrhythmias in PAH-CHD children with a sensitivity of 87%, specificity of 80%, and accuracy of 85%.…”

Section: Discussionsupporting

confidence: 93%

“…A cutoff value of 61 ms was found to predict the occurrence of arrhythmias in PAH-CHD children with a sensitivity of 93%, specificity of 80%, and accuracy of 85%. This is concordant with other investigators [12], [13] who reported increased QTd in patients with PAH-CHD relative to those without PAH and the Control group. Similarly, Goldener et al [16] revealed that the risk of serious ventricular arrhythmia or sudden cardiac death was more obvious in patients with QTd of more than 65 ms.…”

Section: Discussionsupporting

confidence: 93%

See 1 more Smart Citation

Predictive value of P-wave and QT interval dispersion in children with congenital heart disease and pulmonary arterial hypertension for the occurrence of arrhythmias

Saleh

Shabana

Amrousy

et al. 2019

Journal of the Saudi Heart Association

View full text Add to dashboard Cite

ObjectivesTo evaluate P-wave dispersion (PWD) and QT dispersion (QTd) in children with congenital heart disease and pulmonary arterial hypertension (PAH-CHD) and to investigate the predictive value of both PWD and QTd for prediction of arrhythmias in such children.Materials and methodsWe included 40 children with PAH-CHD as Group I. Forty other children with CHD and no PAH were included as Group II. Forty healthy children of matched age and sex served as a Control group. Electrocardiography was performed to determine PWD and QTd. Furthermore, 24-hour Holter monitoring was performed to detect the presence of arrhythmias. Echocardiographic evaluation was also performed.ResultsQTd and PWD were significantly higher in Group I than in Group II and Control group. A significant positive correlation was present between both QTd and PWD and mean pulmonary artery pressure, right ventricular diameter, pulmonary vascular resistance (PVR), and PVR to systemic vascular resistance ratio. QTd showed 93% sensitivity, 80% specificity, and 85% accuracy for prediction of occurrence of arrhythmias in patients with PAH-CHD at a cutoff point of 61 ms, whereas PWD showed 87% sensitivity, 80% specificity, and 85% accuracy for prediction of arrhythmias at a cutoff point of 32.5 ms in such patients. Logistic regression analysis showed that both QTd and PWD were good predictors for the occurrence of arrhythmias in children with PAH-CHD (p = 0.003 and p = 0.01, respectively).ConclusionsPWD and QTd were good predictors for the occurrence of various arrhythmias in children with PAH-CHD.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 93%

Predictive value of P-wave and QT interval dispersion in children with congenital heart disease and pulmonary arterial hypertension for the occurrence of arrhythmias

Saleh

Shabana

Amrousy

et al. 2019

Journal of the Saudi Heart Association

View full text Add to dashboard Cite

show abstract

“…We found that the risk of atrial and ventricular arrhythmias was increased in the patients with both congenital heart disease and pulmonary hypertension (4). It seems that in addition to iron overload, myocardial fibrosis, structural changes, and ventricular hypertrophy secondary to chronic anemia lead to heart failure in these patients (5).…”

Section: Introductionmentioning

confidence: 99%

Comparison of QT Dispersion With Left Ventricular Mass Index in Early Diagnosis of Cardiac Dysfunction in Patients With β-Thalassemia Major

Noori

Mahjoubifard

Mohammadi

et al. 2014

Iran Red Crescent Med J

View full text Add to dashboard Cite

Background:In electrocardiography (ECG), QT is the interval between the onset of Q wave to the end of the T wave. This interval may be a sign of changes in the ventricular structure in hematologic disorders such as thalassemia major.Objectives:The main goal of this study was to compare the diagnostic value of corrected QT dispersion (QTcd) and QT dispersion (QTd) with left ventricular mass (LVM) and left ventricular mass index (LVMI) as well as to determine their sensitivity and specificity in early detection of the cardiac involvement in patients with β-thalassemia major.Patients and Methods:In a case-control study, 60 patients older than ten years of age with thalassemia major who received regular blood transfusion and iron chelators were selected as the case group and were compared with 60 healthy age- and sex-matched subjects. All patients had myocardial performance index (MPI) of more than 0.5 and MPI for controls was less than 0.5. Echocardiography and ECG were performed for both groups and data were analyzed using appropriate statistical tests.Results:The mean age of cases and controls were 16 ± 2.8 and 16.08 ± 3.01 years, respectively. Male to female ratio was 33:27 in case group and 31:29 in the control group. LVMI in the case group was greater than control group. QTd and QTcd were larger in case group than in control group. The sensitivity and specificity of LVM, LVMI, QTd, and QTcd were as follows: 88.3%, 77.1%; 86.7%, 80%; 93.8%, 80%; and 91.7%, 86.7%, respectively.Conclusions:This study showed acceptable sensitivity and specificity of QTcd and QTd in comparison to LVMI; it seems that standard ECG can be used for early diagnosis of cardiac involvement in asymptomatic patients with thalassemia major.

show abstract

“…During the follow-up evaluation of children with CHD, one-third of children who do not have surgical correction of their CHD can progress to severe pulmonary hypertension [10]. We studied the effect of pulmonary artery pressure measured by echocardiography and cardiac catheterization, and we found no significant effect of pulmonary artery pressure on QTc.…”

Section: Discussionmentioning

confidence: 96%

“…The first group included 20 children with both CHD and pulmonary hypertension. The second group consisted of 20 children with CHD but no pulmonary hypertension, and the third group was composed of 20 healthy children and they found pulmonary hypertension is a risk factor of prolongation of QT (p value 0.001) [10]. Also, Dursunoglu et al [13] determined a statistically significant prolongation of QTc duration in patients with obstructive sleep apnea but not with pulmonary hypertension.…”

Section: Discussionmentioning

confidence: 97%

Repolarization Patterns in Congenital Heart Disease

et al. 2016

View full text Add to dashboard Cite

The aim of this study was to study the repolarization patterns in pediatric patients with cyanotic and acyanotic congenital heart diseases as prolonged QT indicates a myocardium at risk of ventricular arrhythmia. A cross-sectional case-control study included 50 patients with acyanotic congenital heart diseases and 50 patients with cyanotic congenital heart diseases who presented to Catheterization Unit of Cairo University Pediatric Hospital between March 2013 and June 2014. We included 50 healthy children as a control. For all the patients' measurement of oxygen saturation, echocardiography and 12-lead electrocardiogram (ECG) were done and the corrected QT (QTc) was measured. The mean QTc was significantly higher in acyanotic congenital heart diseases with volume overload than in control: 0.426 versus 0.4 s (p = 0.009). Increased left ventricular end-diastolic dimension was significantly associated with QTc prolongation (p = 0.01). Early repolarization was higher in congenital heart diseases (18 % in acyanotic patient, 48 % in cyanotic patients) than in control 6 %. Decreased oxygen saturation was significantly associated with early repolarization (p = 0.01). Prolonged QTc was higher in acyanotic congenital heart diseases with volume overload and increased left ventricular end diastolic dimension was a significant association. Decreased oxygen saturation was a significant association.

show abstract

Dispersion Durations of P-wave and QT Interval in Children With Congenital Heart Disease and Pulmonary Arterial Hypertension

Cited by 18 publications

References 31 publications

Predictive value of P-wave and QT interval dispersion in children with congenital heart disease and pulmonary arterial hypertension for the occurrence of arrhythmias

Predictive value of P-wave and QT interval dispersion in children with congenital heart disease and pulmonary arterial hypertension for the occurrence of arrhythmias

Comparison of QT Dispersion With Left Ventricular Mass Index in Early Diagnosis of Cardiac Dysfunction in Patients With β-Thalassemia Major

Repolarization Patterns in Congenital Heart Disease

Contact Info

Product

Resources

About