Dispersible porous classical polymer photocatalysts for visible light-mediated production of pharmaceutically relevant compounds in multiple solvents

Abstract

Porous classical polymer photocatalyst produced by RAFT mediated PISA, easily dispersible in a broad range of solvents for drug synthesis.

Heterogeneous photocatalysis in flow chemical reactors

“…Zhang and co-workers recently demonstrated that the dispersibility of polymer nanoparticle-supported benzothiadiazole photocatalysts could be improved in a range of different solvents by copolymerising classical solubilising monomers with the same St-BTZ photocatalyst monomer previously reported by Vilela and co-workers [47,139]. They showed that the supported photocatalyst material was an effective HPCat for pharmaceutically relevant transformations in the optimal solvent for the reaction, despite the native solubility of the photocatalyst being poor in those solvents [139].…”

Heterogenisation of a carbonylation catalyst on dispersible microporous polymer nanoparticles

“…Ferguson et al recently utilised this approach to synthesise dispersible porous polymer photocatalytic nanoparticles, which were found to be active for a range of photocatalytic reactions to produce pharmaceutically relevant compounds. 48 The versatility of these porous materials for encapsulation of molecular species has also recently been demonstrated in the formation of organic white-light emitting dispersions. 49 Here we report the synthesis of a new dispersible porous material by co-polymerisation of 4-vinylpyridine (4VP) with DVB in the presence of a PEG-based macro-CTA.…”

Progress in Photocatalytic Synthesis of Benzimidazoles

“…The dispersion of the polymeric photocatalyst in solvent also needs to be improved as it is an important factor to restrict the photocatalytic performance. Recently, a new class of porous photocatalytic polymeric materials comprised mainly of inexpensive classical monomers was prepared by reversible addition fragmentation chain transfer (RAFT) method, [27] which could be highly dispersed in various types of solvents (Scheme 6). The catalyst is based on a large polyethylene glycol chain which is extended by divinylbenzene, fumaronitrile, and crosslinked with 4, 7‐bis (4‐vinylphenyl) benzo thiadiazole (acting as a photocatalyst unit).…”

“… Photocatalytic synthesis of BIs based on the porous polymer catalyst developed by Ferguson et al [27] . and its (a) molecular structure and (b) TEM image.…”

“…The conversions even could process under solvent‐free condition [26,39] . Another work [27] showed that the conversions could successfully proceed in water, MeCN and toluene. The yield of BIs in water was the largest.…”