Dispersal of human and plant pathogens biofilms via nitric oxide donors at 4 °C

Marvasi, Massimiliano; Durie, Ian A.; Henríquez, Tania; Satkute, Aiste; Matuszewska, Marta; Prado, Raphael Carvalho

doi:10.1186/s13568-016-0220-1

Cited by 12 publications

(14 citation statements)

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“…The advantage of using NO donors is the extremely low effect concentrations (picomolar or nanomolar) required. In addition, donors have recently been proposed as dispersant agents to reduce biofilm biomass of pathogens such as Salmonella , pathogenic E. coli and Listeria in materials of industrial interest …”

Section: Resultsmentioning

confidence: 99%

Potential use and perspectives of nitric oxide donors in agriculture

Marvasi

2016

J Sci Food Agric

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Copyright and moral rights to this work are retained by the author and/or other copyright owners unless otherwise stated. The work is supplied on the understanding that any use for commercial gain is strictly forbidden. A copy may be downloaded for personal, non-commercial, research or study without prior permission and without charge.Works, including theses and research projects, may not be reproduced in any format or medium, or extensive quotations taken from them, or their content changed in any way, without first obtaining permission in writing from the copyright holder(s). They may not be sold or exploited commercially in any format or medium without the prior written permission of the copyright holder(s).Full bibliographic details must be given when referring to, or quoting from full items including the author's name, the title of the work, publication details where relevant (place, publisher, date), pagination, and for theses or dissertations the awarding institution, the degree type awarded, and the date of the award.If you believe that any material held in the repository infringes copyright law, please contact the Repository Team at Middlesex University via the following email address: eprints@mdx.ac.ukThe item will be removed from the repository while any claim is being investigated.See also repository copyright: re-use policy: http://eprints.mdx.ac.uk/policies.html#copy 17Technological development in the field of NO donors is rapidly expanding in scope, to include 18 controlling seed germination, plant development, ripening, and increasing shelf life of produce. 19Potential applications in animal production have also been identified. 20This concise review focuses on the use of donors that have shown potential biotechnological 21 applications in agriculture. We provide insights into (i) the role of donors in plant production, (ii) 22 potential use of donors in animal production, and (iii) future approaches to explore the use and 69Of great importance is also the potential neutralization/toxicity of the donors once depleted from 70 the nitric oxide. Some of them may release toxic, active compounds during their decomposition. 71Plant and animal toxicity of by-products needs to be more fully confirmed, especially as 180Further examples of reduced toxicity of lead and cadmium has also been described by Kopyra and 181Gwóźdź (2003) 245Post-harvest strawberries and mushrooms were exposed to diethylenetriamine/nitric oxide 254Use of DETANO was also reported to inhibit browning in apple slices 78,79 . Fresh-cut apples 255(Malus domestica Borkh. 'Granny Smith') were dipped in a DETANO solution and the 256 development of surface browning was examined during subsequent storage at 0°C and 5°C. 257Authors found that dipping in the DETANO solution inhibited the development of browning, 270To our knowledge only one work is available on co-application on NO donors and fertilizers, 271showing perhaps potential applications. Co-application of SNP into a controlled release fertilizer 297Finally, the donor S-n...

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Section: Resultsmentioning

confidence: 99%

Potential use and perspectives of nitric oxide donors in agriculture

Marvasi

2016

J Sci Food Agric

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“…Periodontal treatments, such as supragingival scaling or root planing, have been already shown to have an impact in rheumatoid arthritis [ 153 , 154 ]. As aspirin and other NSAIDs are efficient inhibitors of biofilm formation [ 125 , 126 , 127 , 128 , 129 , 130 , 131 , 132 ], this might be another role of the anti-tumor effects of aspirin, through inhibition of inflammation in the oral mucosa and/or avoiding gut colonization by biofilms or biofilm/platelet aggregates. Aspirin or related NSAIDs might be included in the daily tooth cleaning as well as local antibiotic therapies.…”

Section: Discussionmentioning

confidence: 99%

“…S. aureus , as well as other strains previously thought to be non-producers of biofilms, are always associated with biofilm producer bacteria in this type of polymicrobial colonization [124] . Interestingly, aspirin and other NSAIDs are efficient inhibitors of biofilm formation [ 125 , 126 , 127 , 128 , 129 ] and may control periodontitis though the inhibition of the gingival tissue microbioma-related inflammation [ 74 , 130 , 131 ], as in the examples cited above [ 122 , 123 ]. Resveratrol and its glycosylated derivative THSG [113] have been, intriguingly, proposed for possible complementary treatments for periodontitis through their inhibition of Porphyromonas gingivalis -induced inflammatory responses in human gingival fibroblasts [132] .…”

Section: Main Textmentioning

confidence: 99%

Oral hygiene might prevent cancer

Cordero

Varela-Calviño

2018

Heliyon

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Many evidences support that species from the Human Oral Microbiome Database such as Fusobacterium nucleatum or Bacteroides, linked previously to periodontitis and appendicitis, play a role in colorectal cancer (CRC), including metastasis. These typically oral species are invasive anaerobes that form biofilms in their virulent state.Aspirin (a NSAID) has been recently included into routine CRC prevention rationale. NSAIDs can prevent the growth of neoplastic lesions by inhibiting COX enzymes and another set of recently identified COX-independent targets, which include the WNT, AMPK and MTOR signaling pathways, the crosstalk between nucleoli and NF-κB transcriptional activity in apoptosis, and the biochemistry of platelets. These are signaling pathways related to tumor-promoting inflammation. In this process, pathogens or simple deregulation of the microbiota play an important role in CRC. Aspirin and other NSAIDs are efficient inhibitors of biofilm formation and able to control periodontitis development preventing inflammation related to the microbiota of the gingival tissue, so its seems plausible to include this pathway in the mechanisms that aspirin uses to prevent CRC.We propose arguments suggesting that current oral hygiene methods and other future developments against periodontitis might prevent CRC and probably other cancers, alone or in combination with other options; and that the multidisciplinary studies needed to prove this hypothesis might be relevant for cancer prevention.

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“…Biofilm formation and dispersal were tested following previously described protocols, with the following modifications . Briefly, for Salmonella and E. coli , overnight cultures (10 9 CFU/mL) were grown in colonizing‐factor antigen medium (CFA), the culture was then diluted to 1:100 in CFA and 200 μL were aliquoted into each well of a polypropylene 96‐well plate (Fisher, Waltham, MA, USA).…”

Section: Methodsmentioning

confidence: 99%

“…The dispersal capability of other NO donors has been established recently. Examples of donors previously examined include molsidomine, MAHAMA NONOate, NO‐aspirin, and diethylamine NONOate sodium showing a synergistic effect with diquat (at 4°C), peracetic acid, and hydrogel composed of cellulose nanocrystals (CNC) . The ability of these donors to disperse different preformed biofilms has been demonstrated using Pseudomonas spp., S. enterica , and Listeria spp …”

Section: Introductionmentioning

confidence: 99%

Exploitation of nitric oxide donors to control bacterial adhesion on ready‐to‐eat vegetables and dispersal of pathogenic biofilm from polypropylene

et al. 2020

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BACKGROUND Nitric oxide (NO) donors have been used to control biofilm formation. Nitric oxide can be delivered in situ using organic carriers and acts as a signaling molecule. Cells exposed to NO shift from biofilm to the planktonic state and are better exposed to the action of disinfectants. In this study, we investigate the capability of the NO donors molsidomine, MAHAMA NONOate, NO‐aspirin and diethylamine NONOate to act as anti‐adhesion agents on ready‐to‐eat vegetables, as well as dispersants for a number of pathogenic biofilms on plastic. RESULTS Our results showed that 10 pM molsidomine reduced the attachment of Salmonella enterica sv Typhimurium 14 028 to pea shoots and coriander leaves of about 0.5 Log(CFU/leaf) when compared with untreated control. The association of 10 pmol L−1 molsidomine with 0.006% H2O2 showed a synergistic effect, leading to a significant reduction in cell collection on the surface of the vegetable of about 1 Log(CFU/leaf). Similar results were obtained for MAHMA NONOate. We also showed that the association of diethylamine NONOate at 10 mmol L−1 and 10 pmol L−1 with the quaternary ammonium compound diquat bromide improved the effectiveness of biofilm dispersal by 50% when compared with the donor alone. CONCLUSIONS Our findings reveal a dual role of NO compounds in biofilm control. Molsidomine, MAHMA NONOate, and diethylamine NONOate are good candidates for either preventing biofilm formation or dispersing biofilm, especially when used in conjunction with disinfectants. Nitric oxide compounds have the potential to be developed into a toolkit for pro‐active practices for good agricultural practices (GAPs), hazard analysis and critical control points (HACCP), and cleaning‐in‐place (CIP) protocols in industrial settings where washing is routinely applied. © 2020 Society of Chemical Industry

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Dispersal of human and plant pathogens biofilms via nitric oxide donors at 4 °C

Cited by 12 publications

References 28 publications

Potential use and perspectives of nitric oxide donors in agriculture

Potential use and perspectives of nitric oxide donors in agriculture

Oral hygiene might prevent cancer

Exploitation of nitric oxide donors to control bacterial adhesion on ready‐to‐eat vegetables and dispersal of pathogenic biofilm from polypropylene

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