Dispersal and inhibition of biofilms associated with infections

Yan, Zisui; Huang, Ming-Chun; Melander, Christian; Kjellerup, Birthe V.

doi:10.1111/jam.14491

Cited by 22 publications

(16 citation statements)

References 65 publications

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“…TSBg served as the negative control, and positive controls were chloramphenicol (Sigma-Aldrich) for planktonic cells and dispersin B (Kane Biotech) for biofilms. Dispersin B is a 40 kDa glycoside hydrolase which dissolves mature bacterial biofilms [ 29 ]. The plates were incubated for 20 h at 37 °C without shaking to facilitate biofilm formation.…”

Section: Methodsmentioning

confidence: 99%

Inhibition of Biofilm Formation by Modified Oxylipins from the Shipworm Symbiont Teredinibacter turnerae

et al. 2020

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The bioactivity-guided purification of the culture broth of the shipworm endosymbiont Teredinibacter turnerae strain 991H.S.0a.06 yielded a new fatty acid, turneroic acid (1), and two previously described oxylipins (2–3). Turneroic acid (1) is an 18-carbon fatty acid decorated by a hydroxy group and an epoxide ring. Compounds 1–3 inhibited bacterial biofilm formation in Staphylococcus epidermidis, while only 3 showed antimicrobial activity against planktonic S. epidermidis. Comparison of the bioactivity of 1–3 with structurally related compounds indicated the importance of the epoxide moiety for selective and potent biofilm inhibition.

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Section: Methodsmentioning

confidence: 99%

Inhibition of Biofilm Formation by Modified Oxylipins from the Shipworm Symbiont Teredinibacter turnerae

et al. 2020

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“…Biofilms embrace the capability to resist and survive harsh environmental con and defeat the host immune system, so there is a desire for exploring new antib agents. Emerging biofilm control measures such as small molecule inhibitors, q quenching agents, antimicrobial peptides (AMPs), efflux pump inhibitors (EPIs), q nary ammonium compounds (QACs), and natural phytoconstituents are gaining a Horizontal gene transfer in plasmids and the portability of human carriers has resulted in proclamation of drug resistance over a capacious microbial subdivision and microenvironment [149][150][151][152][153].…”

Section: Emerging Antibiofilm Agentsmentioning

confidence: 99%

Development of Antibiofilm Therapeutics Strategies to Overcome Antimicrobial Drug Resistance

et al. 2022

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A biofilm is a community of stable microorganisms encapsulated in an extracellular matrix produced by themselves. Many types of microorganisms that are found on living hosts or in the environment can form biofilms. These include pathogenic bacteria that can serve as a reservoir for persistent infections, and are culpable for leading to a broad spectrum of chronic illnesses and emergence of antibiotic resistance making them difficult to be treated. The absence of biofilm-targeting antibiotics in the drug discovery pipeline indicates an unmet opportunity for designing new biofilm inhibitors as antimicrobial agents using various strategies and targeting distinct stages of biofilm formation. The strategies available to control biofilm formation include targeting the enzymes and proteins specific to the microorganism and those involved in the adhesion pathways leading to formation of resistant biofilms. This review primarily focuses on the recent strategies and advances responsible for identifying a myriad of antibiofilm agents and their mechanism of biofilm inhibition, including extracellular polymeric substance synthesis inhibitors, adhesion inhibitors, quorum sensing inhibitors, efflux pump inhibitors, and cyclic diguanylate inhibitors. Furthermore, we present the structure–activity relationships (SAR) of these agents, including recently discovered biofilm inhibitors, nature-derived bioactive scaffolds, synthetic small molecules, antimicrobial peptides, bioactive compounds isolated from fungi, non-proteinogenic amino acids and antibiotics. We hope to fuel interest and focus research efforts on the development of agents targeting the uniquely complex, physical and chemical heterogeneous biofilms through a multipronged approach and combinatorial therapeutics for a more effective control and management of biofilms across diseases.

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“…35 Bacterial biofilms have a significant impact on the virulence and viability of bacteria, not only in the medical field but also in industries that require a highly sterile environment, such as food processing, where biofilms can significantly affect people's manufacture and life. 36,37 Phage Interacts with Biofilm Common disinfectants and antibiotics are more effective in removing free cells but do not readily penetrate and destroy biofilms and are less effective against antibioticresistant bacteria, with a reported 100-1000-fold increase in antibiotics concentration required to eradicate bacteria containing biofilms. [38][39][40][41] Due to different microorganisms, the type of mixed biofilm increases with symbiotic microorganisms, which are likely to be more resistant to antibiotics and increase the therapeutic burden.…”

Section: Impact Of Bacterial Biofilm Presencementioning

confidence: 99%

Bacteriophage – A Promising Alternative Measure for Bacterial Biofilm Control

Tian¹,

Li²,

Nazir³

et al. 2021

IDR

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Bacterial biofilms can enhance bacteria's viability by providing resistance against antibiotics and conventional disinfectants. The existence of biofilm is a serious threat to human health, causing incalculable loss. Therefore, new strategies to deal with bacterial biofilms are needed. Bacteriophages are unique due to their activity on bacteria and do not pose a threat to humans. Consequently, they are considered safe alternatives to drugs for the treatment of bacterial diseases. They can effectively obliterate bacterial biofilms and have great potential in medical treatment, the food industry, and pollution control. There are intricate mechanisms of interaction between phages and biofilms. Biofilms may prevent the invasion of phages, and phages can kill bacteria for biofilm control purposes or influence the formation of biofilms. At present, there are various measures for the prevention and control of biofilms through phages, including the combined use of drugs and the application of phage cocktails. This article mainly reviews the function and formation process of bacterial biofilms, summarizes the different mechanisms between phages and biofilms, briefly explains the phage usage for the control of bacterial biofilms, and promotes phage application maintenance human health and the protection of the natural environment.

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Dispersal and inhibition of biofilms associated with infections

Cited by 22 publications

References 65 publications

Inhibition of Biofilm Formation by Modified Oxylipins from the Shipworm Symbiont Teredinibacter turnerae

Inhibition of Biofilm Formation by Modified Oxylipins from the Shipworm Symbiont Teredinibacter turnerae

Development of Antibiofilm Therapeutics Strategies to Overcome Antimicrobial Drug Resistance

Bacteriophage – A Promising Alternative Measure for Bacterial Biofilm Control

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