Disparity in the micronutrient content of diets high or low in advanced glycation end products (AGEs) does not explain changes in insulin sensitivity

Pearce, Karma; Hatzinikolas, A.; Moran, Lisa J.; Courten, Maximilian Pangratius J De; Forbes, Josephine M.; Scheijen, Jean L.J.M.; Schalkwijk, Casper G.; Courten, Barbora de

doi:10.1080/09637486.2017.1319468

Cited by 2 publications

(2 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Additionally, they included slightly younger and more insulin-sensitive participants (age 34 ± 10 years, M-value 7.0 ± 2.5 mg/kg/min), and effects of low- and high-AGE diet might be more profound in this group when compared with our older and less insulin-sensitive participants. Importantly, differences in AGE content of low- and high-AGE diets in the De Courten study were achieved by carefully matching low- and high-AGE food products based on differences in cooking techniques ( 40 ). In contrast, our low- and high-AGE diets were designed as stand-alone diets, and differences in AGEs were not solely achieved by cooking methods.…”

Section: Discussionmentioning

confidence: 99%

A 4-week high-AGE diet does not impair glucose metabolism and vascular function in obese individuals

Linkens¹,

Houben²,

Niessen³

et al. 2022

JCI Insight

Self Cite

View full text Add to dashboard Cite

Background: Accumulation of advanced glycation endproducts (AGEs) may contribute to the pathophysiology of type 2 diabetes and its vascular complications.AGEs are widely present in food, but whether restricting AGE intake improves risk factors for type 2 diabetes and vascular dysfunction is controversial. Research design and methods: Abdominally obese but otherwise healthy individuals were randomly assigned to a specifically designed 4-week diet low or high in AGEs in a double blind parallel-design. Insulin sensitivity, secretion, and clearance were assessed by a combined hyperinsulinemic-euglycemic and hyperglycemic clamp. Micro-and macrovascular function, inflammation, and lipid profile were assessed by state-of-art in vivo measurements and biomarkers. Specific urinary and plasma AGEs N ε -(carboxymethyl)lysine (CML), N ε -(1-carboxyethyl)lysine (CEL), and N δ -(5-hydro-5methyl-4-imidazolon-2-yl)-ornithine (MG-H1) were assessed by mass spectrometry.Results: In 73 individuals (22 males, mean ± SD age and BMI 52 y ± 14, 30.6 kg/m2 ± 4.0), intake of CML, CEL, and MG-H1 differed 2.7, 5.3, and 3.7-fold between the low and high AGE diets, which led to corresponding changes of these AGEs in urine and plasma. Despite this, there was no difference in insulin sensitivity, secretion, or clearance, micro-and macrovascular function, overall inflammation, or lipid profile between the low and high dietary AGE groups (all p for treatment effects > 0.05). Conclusions:This comprehensive RCT demonstrates very limited biological consequences of a 4-week diet low or high in AGEs in abdominally obese individuals.

show abstract

Section: Discussionmentioning

confidence: 99%

A 4-week high-AGE diet does not impair glucose metabolism and vascular function in obese individuals

Linkens¹,

Houben²,

Niessen³

et al. 2022

JCI Insight

Self Cite

View full text Add to dashboard Cite

show abstract

“…Based on the literature review, the effect of TPP on the Glo system activity in diabetes has not yet been investigated. The reducing effect of thiamine on the formation of AGEs in vitro and in vivo as well as MGO formation in the in vitro were presented (22,23). However, the effects of thiamine on different glycation products in vivo and in vitro was investigated.…”

Section: Discussionmentioning

confidence: 99%

Thiamine pyrophosphate improved vascular complications of diabetes in rats with type 2 diabetes by reducing glycation, oxidative stress, and inflammation markers

Mahdavifard

Nakhjavani

2020

mjiri

View full text Add to dashboard Cite

Background: Thiamine deficiency contributes to hyperglycemia and diabetes complications. Thus, in this study, the effect of thiamine pyrophosphate (TPP) on the in vivo and in vitro formation of glycation, oxidative stress, and inflammatory markers (the main contributors of vascular diabetes complications) was examined in type 2 diabetes rat model. Methods: Type 2 diabetes was induced in rats with a combination of streptozotocin and nicotinamide (55+200 mg/kg). Two groups of rats, healthy and diabetic, were treated with 0.1% TPP in drinking water daily for 3 months and the 2 others received water only. The glucose, insulin, early to end glycation products, the activity of glyoxalase system, lipid profile, LDL oxidation markers, inflammatory markers, creatinine in the serum, and proteinuria in the urine of all rats were determined. Moreover, albumin and LDL were incubated with glucose in the presence and absence of TPP, and the samples were investigated for glycation and oxidation products. Different variables in all 4 groups were compared with multiple analysis of variance (MANOVA-Tukey) test using SPSS version 16. Significance level was set at p<0.05.Results: TPP decreased the formation of diverse glycation and oxidation products in both in vivo (glycated LDL= 144.50±3.48 and oxidized LDL= 54.08±2.67 μmol/l) and in vitro (glycated LDL= 107.00±2.82 and oxidized LDL= 50.83±1.22 μmol/l). In addition, the vitamin reduced fasting blood sugar (9.23±0.29), insulin resistance (9.10±0.50), tumor necrosis factor-α (285.43±15.97), interleukin-6 (257.65±13.06), and improved the lipid profile, the activity of Glo system (Glo-I= 31.65±1.06 and Glo-II= 27.01±0.90 U/mL) and renal function in the diabetic rat (p<0.001).Conclusion: TPP decreased the major risk factors for diabetic complications and corrected the alternations of glucose and lipid metabolism in type 2 diabetic rats; thus, it is recommended for diabetes treatment.

show abstract

Disparity in the micronutrient content of diets high or low in advanced glycation end products (AGEs) does not explain changes in insulin sensitivity

Cited by 2 publications

References 20 publications

A 4-week high-AGE diet does not impair glucose metabolism and vascular function in obese individuals

A 4-week high-AGE diet does not impair glucose metabolism and vascular function in obese individuals

Thiamine pyrophosphate improved vascular complications of diabetes in rats with type 2 diabetes by reducing glycation, oxidative stress, and inflammation markers

Contact Info

Product

Resources

About