Disparities in breast cancer characteristics and outcomes by race/ethnicity

Ooi, Siew Loon; Martı́nez, Marı́a Elena; Li, Christopher I.

doi:10.1007/s10549-010-1191-6

Cited by 252 publications

(257 citation statements)

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“…[16][17][18][19] Among the Asian subgroups, we observed that Japanese patients had better DSS rates than NHW patients and patients in other Asian subgroups, which is also consistent with previous reports. [19][20][21] We also observed that Hawaiian/Pacific Islander patients were more likely to be diagnosed with advanced disease (stage III or IV) and, as expected, had worse DSS rates than NHW patients and patients in all other Asian subgroups.…”

Section: Discussionsupporting

confidence: 90%

“…This is consistent with other studies demonstrating that Japanese patients are more likely to have ER-positive or PRpositive tumors than black or HW patients or patients in other Asian subgroups. 10,18,19,[22][23][24] The survival advantage of Japanese over NHW and other Asian subtypes slightly decreased after controlling for disease stage, which is consistent with a report by Pineda et al 20 Also, in agreement with previously published data, this survival advantage appears to be limited to the localized and regional stages. Once distant metastases are present (stage IV), Japanese do not fare as well as NHWs and other Asian subtypes.…”

Section: Discussionsupporting

confidence: 88%

“…39,40 Filipino patients had a similar DSS compared with Chinese, Korean, Indian/Pakistani, Vietnamese, and NHW patients, which differed from findings in a previously reported study by Ooi et al, who had a smaller sample size of Filipino patients in their study (4344 vs 10,915 in the current study). 19 The current study has several limitations. First, as in any other retrospective investigation, it was subject to selection bias.…”

Section: Discussionmentioning

confidence: 90%

“…This suggests that Hawaiian/Pacific Islander patients may experience issues related to access to care with respect to screening and follow-up after a breast cancer diagnosis rather than differences in tumor biology. 19 Consideration of the issues related to access to care for each subgroup may be useful in developing strategies to improve access and outcome. We observed distinct differences with respect to breast cancer stage, tumor biomarkers, and treatment among other Asian subgroups.…”

Section: Discussionmentioning

confidence: 99%

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Comparative analysis of clinicopathologic features, treatment, and survival of Asian women with a breast cancer diagnosis residing in the United States

Liu

et al. 2012

Cancer

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BACKGROUND:It has been established that disparities by ethnicity in the rates of breast cancer diagnoses and disease‐specific survival (DSS) exist in the United States. However, few studies have assessed differences specifically between Asians and other ethnic groups or among Asian subgroups.METHODS:The authors used the Surveillance, Epidemiology, and End Results database to identify patients who were diagnosed with invasive breast cancer between 1988 and 2008. Clinicopathologic features, treatment, and DSS rates were compared among broad ethnic groups and among Asian subgroups.RESULTS:In total, there were 658,691 patients in the study, including 511,701 non‐Hispanic white (NHW) women (77.7%), 57,890 black women (8.8%), 45,461 Hispanic white (HW) women (6.9%), and 43,639 Asian women (6.6%). The Asian cohort was divided into the following subgroups: Filipino, Chinese, Japanese, Indian/Pakistani, Korean, Vietnamese, Hawaiian/Pacific Islander, and other. Patients in all the Asian subgroups, except Japanese, were younger at diagnosis than NHW patients. After adjustment for disease stage, Japanese patients diagnosed with stage I through III disease had better DSS rates than patients in the NHW group or in the other Asian subgroups. Hawaiian/Pacific Islander patients with stage III or IV disease had worse DSS rates than NHW patients and patients in the other Asian subgroups. All other Asian subgroups had DSS rates similar to the DSS rate in the NHW group.CONCLUSIONS:The current results indicated that disparities exist for Asian women with breast cancer who reside in the United States compared with NHW groups and among Asian subgroups. Differences in presenting clinicopathologic features may affect DSS rates, suggesting that further investigation of these disparities is warranted to increase early detection and treatment for specific subgroups. Cancer 2012. © 2012 American Cancer Society.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

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Comparative analysis of clinicopathologic features, treatment, and survival of Asian women with a breast cancer diagnosis residing in the United States

Liu

et al. 2012

Cancer

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“…Studies highlighting heterogeneity in breast cancer risk between Hispanic women underscore the importance of differences in country of origin, duration of residence in the United States, and acculturation in estimating the risk of breast cancer (10,(21)(22)(23). Further, there is evidence of genomic differences between Hispanic subgroups in the Unites States (24,25).…”

Section: Discussionmentioning

confidence: 99%

Projecting Individualized Absolute Invasive Breast Cancer Risk in US Hispanic Women

Banegas

John

Slattery

et al. 2016

JNCI J Natl Cancer Inst

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Background: There is no model to estimate absolute invasive breast cancer risk for Hispanic women. Methods: The San Francisco Bay Area Breast Cancer Study (SFBCS) provided data on Hispanic breast cancer case patients (533 US-born, 553 foreign-born) and control participants (464 US-born, 947 foreign-born). These data yielded estimates of relative risk (RR) and attributable risk (AR) separately for US-born and foreign-born women. Nativity-specific absolute risks were estimated by combining RR and AR information with nativity-specific invasive breast cancer incidence and competing mortality rates from the California Cancer Registry and Surveillance, Epidemiology, and End Results program to develop the Hispanic risk model (HRM). In independent data, we assessed model calibration through observed/expected (O/E) ratios, and we estimated discriminatory accuracy with the area under the receiver operating characteristic curve (AUC) statistic. Results: The US-born HRM included age at first full-term pregnancy, biopsy for benign breast disease, and family history of breast cancer; the foreign-born HRM also included age at menarche. The HRM estimated lower risks than the National Cancer Institute's Breast Cancer Risk Assessment Tool (BCRAT) for US-born Hispanic women, but higher risks in foreign-born women. In independent data from the Women's Health Initiative, the HRM was well calibrated for US-born women (observed/expected [O/E] ratio ¼ 1.07, 95% confidence interval [CI] ¼ 0.81 to 1.40), but seemed to overestimate risk in foreign-born women (O/E ratio ¼ 0.66, 95% CI ¼ 0.41 to 1.07). The AUC was 0.564 (95% CI ¼ 0.485 to 0.644) for US-born and 0.625 (95% CI ¼ 0.487 to 0.764) for foreign-born women. Conclusions: The HRM is the first absolute risk model that is based entirely on data specific to Hispanic women by nativity. Further studies in Hispanic women are warranted to evaluate its validity.

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Characteristics Associated With Differences in Survival Among Black and White Women With Breast Cancer

Silber

Rosenbaum

Clark

et al. 2013

JAMA

273

232

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Disparities in breast cancer characteristics and outcomes by race/ethnicity

Cited by 252 publications

References 25 publications

Comparative analysis of clinicopathologic features, treatment, and survival of Asian women with a breast cancer diagnosis residing in the United States

Comparative analysis of clinicopathologic features, treatment, and survival of Asian women with a breast cancer diagnosis residing in the United States

Projecting Individualized Absolute Invasive Breast Cancer Risk in US Hispanic Women

Characteristics Associated With Differences in Survival Among Black and White Women With Breast Cancer

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