“…In addition to pex5‐2 , other Arabidopsis mutants with low PEX5 levels include pex6 and pex26 mutants (Gonzalez et al., ; Zolman & Bartel, ), which show defects in retrotranslocating PEX5 from the peroxisomal membrane (Gonzalez et al., ; Ratzel et al., ), and pex7 mutants (Ramón & Bartel, ), which are defective in the PEX5‐interacting PTS2 receptor and show import defects of not only PTS2 proteins but also PTS1 proteins (Ramón & Bartel, ; Woodward & Bartel, ). Interestingly, reducing function of PEX2, one of the peroxisomal RING ubiquitin‐protein ligases, restores PEX5 levels in pex6‐1 and pex26‐1 but not pex7‐1 mutants (Burkhart et al., ; Gonzalez et al., ), suggesting multiple avenues for PEX5 degradation. It will be interesting to learn whether the apparent pex5‐2 instability that we observe can be attributed to the peroxisomal ubiquitination machinery.…”