2002
DOI: 10.1093/jn/132.7.2076
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Disparate In Vitro and In Vivo Antileukemic Effects of Resveratrol, a Natural Polyphenolic Compound Found in Grapes

Abstract: Resveratrol (trans-3,4',5-trihydroxystilbene), a polyphenol found in grapes and grape wine, has been reported to exhibit cardioprotective and chemopreventive activity against chemical carcinogenesis. It has also been shown to have growth inhibitory activity toward solid tumors in vivo. However, the antitumor activity of resveratrol against hematologic tumors in vivo has not been examined. In this study, the antileukemic activity of resveratrol in vitro and in vivo was examined using a mouse myeloid leukemia ce… Show more

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Cited by 112 publications
(77 citation statements)
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“…Previous studies have documented that resveratrol-induced apoptosis involved caspase activation, both in vitro (10 -13) and in vivo (43,44), which was further confirmed in the cell lines tested in the present study. The caspases involved in the death process and the pathways leading to their activation could differ from one cell type to another.…”
Section: Discussionsupporting
confidence: 89%
“…Previous studies have documented that resveratrol-induced apoptosis involved caspase activation, both in vitro (10 -13) and in vivo (43,44), which was further confirmed in the cell lines tested in the present study. The caspases involved in the death process and the pathways leading to their activation could differ from one cell type to another.…”
Section: Discussionsupporting
confidence: 89%
“…29,30 Therefore, resveratrol treatment could activate SirT1 and potentially benefit FA patients in their battle against oxidative genotoxicity and genome instability. Since resveratrol has the potential to benefit FA patients, has been previously used in rodents, and is nontoxic, 31 we administered resveratrol to Fancd2 Ϫ/Ϫ mice, and found that this agent partially corrected hematopoietic defects in these mice.…”
Section: Fancd1/brca2 Fancd2 Fance Fancf Fancg/xrcc9 Fanci Fancmentioning
confidence: 99%
“…In light of the bioactivities of resveratrol, 27,28,31 we hypothesized that this compound could enhance hematopoiesis in Fancd2 Ϫ/Ϫ mice. Fancd2 Ϫ/Ϫ mice and their wild-type littermates were treated with either control diet or diet supplemented with resveratrol.…”
Section: Resveratrol Treatment Partially Corrected the Hematopoietic mentioning
confidence: 99%
“…Res (3,5,4'-trihydroxy-trans-stilbene), a naturally polyphenolic compound, has been identified in the skin of red grapes, peanuts and various food products. It has a variety of important biological effects such as suppression of platelet aggregation, anti-inflammatory, anti-oxidant, and vasorelaxant activities (5)(6)(7). Res also exhibits antitumor properties by blocking the three stages of carcinogenesis, initiation, promotion and progression (8).…”
Section: Introductionmentioning
confidence: 99%