Disorders of Thrombosis and Hemostasis in Pregnancy

Abstract

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The Effect of Hemoglobin Correction by Blood Transfusion on Pregnancy Outcomes in Minor and Intermedia Thalassemia Patients: A Single-Blind Controlled Randomized Clinical Trial

“…The effect of blood transfusion on pregnancy outcome has potential importance (Howard et al, 2015). Pregnant women with beta thalassemia intermedia who infrequently receive blood transfusion expose to the risk of alloimmunization.…”

“…Pregnant women with beta thalassemia intermedia who infrequently receive blood transfusion expose to the risk of alloimmunization. Therefore, the risk of low birth weight and preterm delivery should be balanced with the risk of alloimmunization (Howard et al, 2015). Currently Transfusion therapy is not routine treatment of beta thalassemia intermedia.…”

“…The frequency of thalassemia in provinces around Persian Gulf, the south of Iran is high and reaches 8-10% (Zandian, Keikhaie, Pedram, Kianpoor, & Ghahfarokhi, 2009). Thalassemia is an inherited hemoglobin disorder in which mutated globin gene results in the various degrees of defects including globin production, an imbalance in alpha/beta globin chain synthesis, an ineffective erythropoiesis, and varying severity of disease and anemia (Howard, Tuck, Eissa, & Porter, 2015). In addition, it is the second reason for hypochromic anemia and anemia in pregnancy after iron deficiency (Yordanova et al, 2013).…”

“…In addition, it is the second reason for hypochromic anemia and anemia in pregnancy after iron deficiency (Yordanova et al, 2013). beta-thalassemia major (Howard et al, 2015). The pregnancy in thalassemia major is compromised by transfusion support; however, fertility is possible in the majority of patients with thalassemia intermedia (Nassar et al, 2006).…”