Disorders of the Neurologic System

Aleman, Monica R; Nout‐Lomas, Yvette S.; Reed, Stephen M.

doi:10.1016/b978-0-323-44329-6.00011-5

Cited by 12 publications

(15 citation statements)

References 697 publications

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Section: Methods Validationsupporting

confidence: 58%

“…The Mg isotopic composition of the CSF from hydrocephalus patients ranged between −0.65 and 0.30‰, and on average it is similar to that reported for serum of healthy individuals, potentially attributed to the fact that CSF is biologically produced as an ultrafiltrate of plasma. 32 However, further CSF analysis increasing the amount of individuals is required for establishing the Mg isotopic variability more exhaustively. The Mg isotopic composition of the quality control CSF material was enriched in the light 24 Mg isotope compared to that of the CSF from hydrocephalus patients and to that of the Seronorm serum reference material (by about −1.0 and −1.3‰, respectively).…”

Section: ■ Methods Validationmentioning

confidence: 99%

See 1 more Smart Citation

Multicollector Inductively Coupled Plasma–Mass Spectrometry with 10¹³ Ω Faraday Cup Amplifiers for Ultrasensitive Mg Isotopic Analysis of Cerebrospinal Fluid Microsamples

et al. 2020

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Magnesium isotopic analysis of cerebrospinal fluid (CSF) is a potentially interesting approach for studies on neurodegeneration. However, this type of analysis is challenging because of the invasiveness of the sampling and small sample volume. In this work, a novel analytical method was developed for ultrasensitive Mg isotopic analysis of CSF microsamples via multicollector inductively coupled plasma−mass spectrometry (MC-ICP-MS) using high-gain 10 13 Ω Faraday cup amplifiers. The intermediate and internal errors on the δ 26 Mg value were improved up to fourfold using 10 13 Ω resistors for the monitoring of both the 24 Mg and 26 Mg isotopes and up to twofold using a 10 11 Ω resistor for the most abundant 24 Mg isotope and a 10 13 Ω resistor for the 26 Mg isotope. Magnesium isotope ratios measured at a concentration level of 7−10 μg L −1 were in good agreement with those obtained using the conventional method at a concentration level of 150 μg L −1. The expanded uncertainty for the quality control CSF material obtained at the ultratrace level was ±0.16‰. Ultrasensitive Mg isotopic analysis was carried out for CSF from hydrocephalus patients using only 5 μL of sample. δMg values thus obtained were not significantly different from those obtained using the conventional method using a sample volume of 400 μL instead (p ≤ 0.05). The Mg isotopic composition of the CSF from hydrocephalus patients ranged between −0.65 and 0.30‰, with a mean δ 26 Mg value of −0.14 ± 0.27‰.

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Section: Methods Validationsupporting

confidence: 58%

Section: ■ Methods Validationmentioning

confidence: 99%

Multicollector Inductively Coupled Plasma–Mass Spectrometry with 10¹³ Ω Faraday Cup Amplifiers for Ultrasensitive Mg Isotopic Analysis of Cerebrospinal Fluid Microsamples

et al. 2020

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“…Some laboratory test results may indicate a different, e.g., viral, etiology of the central nervous system dysfunction. Furthermore, CSF tests do not normally reveal any abnormalities when performed within the first two weeks of the infection [65]. Therefore, it is important to find the best diagnostic marker for neuroborreliosis.…”

Section: Diagnosismentioning

confidence: 99%

Chemokine Ligand 13 (CXCL13) in Neuroborreliosis and Neurosyphilis as Selected Spirochetal Neurological Diseases: A Review of Its Diagnostic Significance

Gudowska-Sawczuk

Mroczko

2020

IJMS

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Neuroborreliosis (NB) and neurosyphilis (NS) are abnormal conditions caused by spirochetal bacteria which affect the nervous system. Diagnosis of neuroborreliosis and neurosyphilis is determined by clinical examination of visible symptoms, serum and cerebrospinal fluid (CSF) analysis, and serological detection of antibodies against Borrelia burgdorferi sensu lato and Treponema pallidum, respectively. Establishing a diagnosis may sometimes pose a number of diagnostic difficulties. A potential role of chemokine ligand 13 (CXCL13) as an accurate diagnostic biomarker of intrathecal inflammation has been suggested. In this review, we focused on changes in serum and cerebrospinal fluid concentration of chemokine ligand 13 in selected spirochetal neurological diseases neuroborreliosis and neurosyphilis reported in the available literature. We performed an extensive search of the literature relevant to our investigation via the MEDLINE/PubMed database. It has been proven that CXCL13 determination can provide rapid information regarding central nervous system inflammation in patients with selected spirochetosis. We described that neuroborreliosis and neurosyphilis are associated with an elevated CXCL13 concentration, mainly in the cerebrospinal fluid. Moreover, literature data suggest that CXCL13 determination is the most interesting additional marker for diagnosis and monitoring of neuroborreliosis and neurosyphilis thanks to its high sensitivity. Based on these published findings, we suggest that CXCL13 has high diagnostic utility and may be applied in laboratory diagnostics as a potential diagnostic marker in human spirochetal neurologic diseases.

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“…The neurologic clinical signs caused by these infections in horses are similar or identical to the signs induced by several other pathogens, including EHV-1 and Rabies virus [120]. Therefore, laboratory tests are crucial for an accurate diagnosis.…”

Section: Flaviviral Encephalitismentioning

confidence: 95%

“…These viruses affect the nervous system, so the clinical signs can be identical for EEV, VEEV and WEEV, with severe neurologic disease and frequently death [120]. The mortality rate of EEEV and VEEV infection can reach up to 90% in most of the equine cases, while WEEV is least lethal in horses, with a mortality rate of approximately 30% [184,185].…”

Section: Alphaviral Encephalitismentioning

confidence: 99%

Viral Diseases that Affect Donkeys and Mules

Câmara

Bueno

Resende

et al. 2020

Animals

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Donkeys (Equus asinus) and mules represent approximately 50% of the entire domestic equine herd in the world and play an essential role in the lives of thousands of people, primarily in developing countries. Despite their importance, donkeys are currently a neglected and threatened species due to abandonment, indiscriminate slaughter, and a lack of proper sanitary management. Specific knowledge about infectious viral diseases that affect this group of Equidae is still limited. In many cases, donkeys and mules are treated like horses, with the physiological differences between these species usually not taken into account. Most infectious diseases that affect the Equidae family are exclusive to the family, and they have a tremendous economic impact on the equine industry. However, some viruses may cross the species barrier and affect humans, representing an imminent risk to public health. Nevertheless, even with such importance, most studies are conducted on horses (Equus caballus), and there is little comparative information on infection in donkeys and mules. Therefore, the objective of this article is to provide a brief update on viruses that affect donkeys and mules, thereby compromising their performance and well-being. These diseases may put them at risk of extinction in some parts of the world due to neglect and the precarious conditions they live in and may ultimately endanger other species’ health and humans.

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Disorders of the Neurologic System

Cited by 12 publications

References 697 publications

Multicollector Inductively Coupled Plasma–Mass Spectrometry with 10¹³ Ω Faraday Cup Amplifiers for Ultrasensitive Mg Isotopic Analysis of Cerebrospinal Fluid Microsamples

Multicollector Inductively Coupled Plasma–Mass Spectrometry with 10¹³ Ω Faraday Cup Amplifiers for Ultrasensitive Mg Isotopic Analysis of Cerebrospinal Fluid Microsamples

Chemokine Ligand 13 (CXCL13) in Neuroborreliosis and Neurosyphilis as Selected Spirochetal Neurological Diseases: A Review of Its Diagnostic Significance

Viral Diseases that Affect Donkeys and Mules

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Disorders of the Neurologic System

Cited by 12 publications

References 697 publications

Multicollector Inductively Coupled Plasma–Mass Spectrometry with 1013 Ω Faraday Cup Amplifiers for Ultrasensitive Mg Isotopic Analysis of Cerebrospinal Fluid Microsamples

Multicollector Inductively Coupled Plasma–Mass Spectrometry with 1013 Ω Faraday Cup Amplifiers for Ultrasensitive Mg Isotopic Analysis of Cerebrospinal Fluid Microsamples

Chemokine Ligand 13 (CXCL13) in Neuroborreliosis and Neurosyphilis as Selected Spirochetal Neurological Diseases: A Review of Its Diagnostic Significance

Viral Diseases that Affect Donkeys and Mules

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Product

Resources

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Multicollector Inductively Coupled Plasma–Mass Spectrometry with 10¹³ Ω Faraday Cup Amplifiers for Ultrasensitive Mg Isotopic Analysis of Cerebrospinal Fluid Microsamples

Multicollector Inductively Coupled Plasma–Mass Spectrometry with 10¹³ Ω Faraday Cup Amplifiers for Ultrasensitive Mg Isotopic Analysis of Cerebrospinal Fluid Microsamples