Disorders of sodium balance in COVID-19 patients: two Tunisian patients report

Saad, G.; Abdelkrim, A. Ben; Abed, Yosra Hasni El; Tahri, S.; Gorchène, A.; Maaroufi, A.; Chadli, M.; Njah, Mansour; Ach, K.

doi:10.11604/pamj.2021.39.199.27626

Cited by 3 publications

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“…Even correction of sodium imbalance in patients in ICU settings has been shown to improve survival rates. [ 54 , 55 ] Whilst, the role of prescription of low molecular weight heparin in hypernatremia patients seems crucial. [ 56 ] As hypernatremia dehydration brings a hypercoagulable state which risks the patient for venous thrombosis, and pulmonary embolism, mainly in ICU patients.…”

Section: Discussionmentioning

confidence: 99%

Association of hypernatremia with outcomes of COVID-19 patients: A systematic review and meta-analysis

et al. 2022

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Background: This systematic review and meta-analysis aimed to assess the association of hypernatremia with the outcomes of COVID-19 patients. Methods: We performed a systematic literature search on PubMed, Google Scholar, and Science Direct until October 2021 and found a total of 131 papers. With meticulous screening finally, 17 papers met the inclusion criteria. COVID-19 patients with sodium levels greater than the reference level were the study population and the outcome of interest was the poor outcome; such as mortality, mechanical ventilation, intensive care unit (ICU) admission, and prolonged hospital stay. The pooled estimate was calculated as the odds ratio (OR). Results: There were 19,032 patients with hypernatremia in the 17 studies included. An overall random effect meta-analysis showed that hypernatremia was associated with mortality (OR: 3.18 [1.61, 6.28], P < .0001, I 2 = 91.99%), prolong hospitalization (OR: 1.97 [1.37, 2.83], P < .001, I 2 = 0.00%) and Ventilation (OR: 5.40 [1.89, 15.42], P < .001, I 2 = 77.35%), ICU admission (OR: 3.99 [0.89, 17.78], P = .07, I 2 = 86.79%). Meta-regression analysis showed the association of age with the ICU outcome of hypernatremia patients. Whereas, other parameters like male, hypertension, chronic kidney disease, and diabetes mellitus did not significantly influence the odds ratio. Conclusion: Hypernatremia was markedly associated with poor outcomes in patients with COVID-19. Hence, a blood ionogram is warranted and special attention must be given to hypernatremia COVID-19 patients.

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Section: Discussionmentioning

confidence: 99%

Association of hypernatremia with outcomes of COVID-19 patients: A systematic review and meta-analysis

et al. 2022

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“…Dysnatraemia in COVID-19 hospitalised patients has generally been associated with poorer outcomes. [30][31][32][33][34][35][36][37][38][39][40][41][42] Both hypernatraemia and hyponatraemia, at admission, have been associated with increased mortality, ICU admission, longer hospitalisation and mechanical ventilation. [32,37,38] Specifically, hyponatraemia was found to be relatively common in hospitalised COVID-19 patients and to be associated with severe illness and increased in-hospital mortality.…”

Section: In Practicementioning

confidence: 99%

“…[32,37,38] Specifically, hyponatraemia was found to be relatively common in hospitalised COVID-19 patients and to be associated with severe illness and increased in-hospital mortality. [34,41,42] On the contrary, admission hypernatraemia or the development of hypernatraemia during hospitalisation have been associated with increased mortality and death. [30,35,36,39,40] Similarly, we found a correlation between hypernatraemia and a long hospital stay.…”

Section: In Practicementioning

confidence: 99%

Laboratory parameters associated with prolonged hospital length of stay in COVID-19 patients in Johannesburg, South Africa

Pillai

Mistry

Roux

et al. 2022

SAMJ

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COVID-19, caused by SARS-CoV-2, has wreaked havoc on global economies and healthcare systems around the world. The World Health Organization declared COVID-19 a pandemic in March 2020. [1] Waves of new infection and new, more transmissible SARS-CoV-2 variants have led to protracted lockdown regulations in many countries. [2][3][4] While lockdown has been an effective method of 'flattening the curve' , it is not a socially or economically sustainable solution for the long term. The ability of healthcare systems to predict and plan for surges in infection has become crucial.The South African (SA) healthcare system is plagued by a geographical maldistribution of resources. There are 125 390 general hospital beds currently available for SA's population of 60 million. [5] Considering the country's overall high burden of disease, identification of potential risk factors or markers that predict length of hospital stay (LoS) in COVID-19 patients may be of great benefit to health authorities and may assist in triage and contingency planning.Abnormal laboratory parameters identified at admission have been reported to predict in-hospital severity of disease and mortality. [6] Lymphopenia, anaemia, thrombocytopenia, neutrophilia and eleva-This open-access article is distributed under Creative Commons licence CC-BY-NC 4.0.

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Case Report: Hypothalamic Amenorrhea Following COVID-19 Infection and Review of Literatures

et al. 2022

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SARS-CoV-2 infection, responsible for the coronavirus disease 2019 (COVID-19), can impair any organ system including endocrine glands. However, hypothalamic–pituitary dysfunctions following SARS-CoV-2 infection remain largely unexplored. We described a case of hypothalamic amenorrhea following SARS-CoV-2 infection in a 36-year-old healthy woman. The diagnostic workup excluded all the causes of secondary amenorrhea, in agreement to the current guidelines, whereas the gonadotropin increase in response to GnRH analogue tests was suggestive for hypothalamic impairment. Therefore, since our patient did not present any organic cause of hypothalamic–pituitary disorder, we hypothesized that her hypothalamic deficiency may have been a consequence of SARS-CoV-2 infection. This assumption, besides on the temporal consecutio, is strengthened by the fact that SARS-CoV-2 infection can impair the hypothalamic circuits, altering the endocrine axes, given that angiotensin-converting enzyme 2 receptors have also been observed in the hypothalamus. We reviewed the literature regarding hypothalamic–pituitary dysfunction in patients with SARS-CoV-2 infection. No study has previously described female hypogonadotropic hypogonadism with secondary amenorrhea following COVID-19. We suggest clinicians focusing greater attention on this possible endocrine disorder.

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Disorders of sodium balance in COVID-19 patients: two Tunisian patients report

Cited by 3 publications

References 0 publications

Association of hypernatremia with outcomes of COVID-19 patients: A systematic review and meta-analysis

Association of hypernatremia with outcomes of COVID-19 patients: A systematic review and meta-analysis

Laboratory parameters associated with prolonged hospital length of stay in COVID-19 patients in Johannesburg, South Africa

Case Report: Hypothalamic Amenorrhea Following COVID-19 Infection and Review of Literatures

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