Disorders of sex development in the dog—Adoption of a new nomenclature and reclassification of reported cases

Poth, Tanja; Breuer, W.; Walter, B.; Hecht, Werner; Hermanns, W.

doi:10.1016/j.anireprosci.2010.04.011

Cited by 75 publications

(94 citation statements)

References 49 publications

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“…Given the absence of polymorphisms and mutations in the coding sequence of the SRY gene, it can be assumed that this gene is not associated with the observed phenotype, as the sequence is present in dogs with normally developed external genital organs. In accordance with the current nomenclature proposed by Poth et al and Meyers-Wallen, the reported case can be classified as a testicular XY (SRY-positive) DSD (Poth et al 2010;Meyers-Wallen 2012). It should be mentioned that phenotypic variation of sex development in XY dogs is quite wide and includes cryptorchidism, hypospadias and ambiguous external genitalia.…”

Section: Discussionsupporting

confidence: 68%

“…Disturbances in successive developmental stages result in congenital disorders collectively referred to as disorders of sex development (DSD; Meyers-Wallen 2012). The causes of DSD include sex chromosome abnormalities, mutations of genes involved in sex determination, and environmental factors that disturb the process (Poth et al 2010;Meyers-Wallen 2012). Among chromosomal DSD the most frequent in dogs are X monosomy (77,X), as well as trisomies (79,XXX and 79,XXY).…”

mentioning

confidence: 99%

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Penile hypoplasia and rudimentary prepuce in a dog (78,XY; SRY-positive): a case report

Różańska¹,

Szczerbal²,

Stachowiak³

et al. 2016

Vet. Med. - Czech

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Section: Discussionsupporting

confidence: 68%

mentioning

confidence: 99%

Penile hypoplasia and rudimentary prepuce in a dog (78,XY; SRY-positive): a case report

Różańska¹,

Szczerbal²,

Stachowiak³

et al. 2016

Vet. Med. - Czech

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“…Among chromosomal aberrations altering sex development the most common are sex chromosome aneuploidies (mainly monosomy X and trisomy XXY). Also translocation of the Y chromosome fragment carrying the Sry gene into the X chromosome or autosome causes disorders of sex development in XX males (Poth et al 2010, Meyers-Wallen 2012.…”

Section: Introductionmentioning

confidence: 99%

Morphological analysis of testicles in cats with disorders of sex development

Dzimira

Niżański

Madej

2017

Polish Journal of Veterinary Sciences

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Disorders of sex development (DSD) are rare in cats. They can be caused by chromosomal aberrations, gene mutations or other undefined factors. The aim of the present study was to compare the histological structure and immunohistochemical reactivity of testes in cats with DSD and in healthy cats. The research material consisted of the gonads of four cats -phenotypic males with an incorrect structure of the reproductive system. The control group consisted of the testes of four healthy cats -routinely castrated phenotypical males. The material was fixed with formalin and embedded in paraffin; the sections were stained with hematoxylin and eosin. The immunohistochemical investigation were performed using monoclonal and polyclonal antibodies directed against desmin, vimentin, actin of smooth muscles, S100 protein and MCM3 protein. The results obtained allow concluding that the testes of cats with DSD differed in certain respects, mainly in the number of blood vessels, from the normal testes. Moreover, the results of immunohistochemical examination indicate that in the testes of cats with DSD the number of supporting cells is lower, the amount of interstitial cells is comparable and spermatogenesis is correct es compared to those determined in the control gonads. The number of blood vessels in cats with DSD is reduced by about 30%. It confirms the recommendations for castration of these animals in order to eliminate the potential inheritance of sex development disorders.

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“…No obstante, según la clasificación reciente propuesta por Poth et al (2010), el paciente puede ser diagnosticado como macho con un desorden del desarrollo sexual (DSD) fenotípico (78, XY). Sin embargo, no es posible asegurar si hay persistencia de los FIGURA 1.…”

Section: Resultsunclassified

“…Existen diversos tipos de intersexualidad que se clasifican en anormalidades del sexo cromosómico, anormalidades del sexo gonadal o anormalidades del sexo fenotípico, con diferentes subcategorías, de acuerdo a la nueva clasificación para caninos (Poth et al 2010). Estos tipos de intersexualidad se subclasifican tradicionalmente como verdaderos hermafroditas y pseudohermafroditas, machos y hembras, pero ello ha sido replanteado tras la propuesta de Poth et al (2010), teniendo en cuenta la gran particularidad de anormalidades y causas diferentes que se pueden presentar en el desarrollo.…”

Section: Introductionunclassified

Un caso de desorden del desarrollo sexual en un canino mestizo

Valencia

González

Rincón

2017

Rev. Med. Vet. Zoot.

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RESUMENLos desórdenes del desarrollo sexual se pueden presentar en diferentes animales domésticos, aunque no son muy comunes. Se clasifican en tres grupos de anormalidades: del desarrollo cromosómico, del desarrollo gonadal y del sexo fenotípico, y presentan diferentes subcategorías. El objetivo de este trabajo fue describir las características fenotípicas, cromosómicas y anatómicas de los órganos reproductores de un paciente canino, aparentemente hembra, de 3 años de edad, con desorden del desarrollo sexual, que presentaba una protuberancia a nivel vaginal con sangrado y presencia de pus; en la anamnesis reportan comportamiento de macho. Se realizó un examen general por sistemas, ecografía abdominal ventral, radiografía latero-lateral, cuadro hemático y cariotipo con bandas R-replicativas. Tras la evaluación se encontró un clítoris agrandado (pseudopene) con orificio uretral que mostró resistencia a la colocación de una sonda. La radiografía mostró una estructura similar al hueso del pene y la ecografía reveló una estructura compatible con el cuello del útero en una hembra y una estructura lateral parecida al tejido gonadal. El cariotipo fue típico de un macho, compatible con un macho seudohermafrodita, lo cual permite clasificar al individuo como XY, con un desorden del desarrollo sexual fenotípico (78, XY) según la nueva clasificación. Con las herramientas diagnósticas disponibles en Colombia es posible realizar un diagnóstico diferencial adecuado. Sin embargo, falta disponibilidad de pruebas diagnósticas específicas como FISH y mediciones serológicas. Palabras clave: ambigüedad sexual, intersexualidad, hermafroditismo canino. A CASE OF A DISORDER SEXUAL DEVELOPMENT IN A HYBRID DOG ABSTRACTThe disorders of sex development can occur in different domestic animals, but they are not very common. They are classified as sex chromosomic disorders, gonadal sex development disorders and phenotypic sex disorders and have different subcategories. The aim of this study was to describe the phenotypic, chromosomal and anatomical traits of the reproductive organs of a canine patient 3-year-old, apparently female with disorder of sexual development, which presented a protuberance into the vagina with bleeding and pus, which anamnesis male behavior report. A general examination was performed by systems, ventral abdominal ultrasound, latero-lateral radiography, blood count and karyotype

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Disorders of sex development in the dog—Adoption of a new nomenclature and reclassification of reported cases

Cited by 75 publications

References 49 publications

Penile hypoplasia and rudimentary prepuce in a dog (78,XY; SRY-positive): a case report

Penile hypoplasia and rudimentary prepuce in a dog (78,XY; SRY-positive): a case report

Morphological analysis of testicles in cats with disorders of sex development

Un caso de desorden del desarrollo sexual en un canino mestizo

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