Disorders of Serum Polyunsaturated Fatty Acids in Renal Transplant Patients

Sikorska-Wiśniewska, Małgorzata; Mika, Adriana; Śledziński, Tomasz; Czaplińska, Monika; Małgorzewicz, Sylwia; Dębska‐Ślizień, Alicja; Chmielewski, Michael S.

doi:10.1016/j.transproceed.2020.01.106

Cited by 3 publications

(5 citation statements)

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“…In this research we investigated the changes/possibility to return to a healthy profile of FA, in order to expanding our understanding of the mechanisms and the role of lipidomic abnormalities in patients after kidney transplantation. The present study confirmed and extended our earlier observations on profound deteriorations of the FA profile in patients treated with renal transplantation [6,11]. End-stage renal disease (ESRD) is a common and deleterious condition with mortality rates comparable to cancer patients [1][2][3].…”

Section: Discussionsupporting

confidence: 90%

“…In the general population, it is dyslipidemia that is the major contributing factor to atherosclerosis, and CVD [17,18]. Our previous studies, among others, have demonstrated that profound lipid abnormalities in renal transplant recipients are present, and not limited solely to increased cholesterol and triglycerides concentrations, but consisting also of severe disturbances of the FA profile [6,7,11]. The exact pattern of lipidomic disorders following renal transplantation, and its associations with atherosclerosis and cardio-vascular risk, remains unknown.…”

Section: Discussionmentioning

confidence: 99%

“…However, even in this patient group, cardiovascular events remain the major cause for mortality [10]. In our earlier studies, we have shown that despite normalization of kidney function parameters in renal transplant recipients, the FA profile is still altered [6,11]. The current evaluation aims at investigating in-depth the FA disorders in this patient population.…”

Section: Introductionmentioning

confidence: 96%

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Analysis of Serum Fatty Acids Profile in Kidney Transplant Recipients

et al. 2021

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Patients with end-stage kidney disease, treated with renal transplantation, are at increased risk of cardio-vascular disease (CVD) and cardio-vascular mortality. They are also characterized by an atherogenic dyslipidemia. Alterations of the fatty acids (FA) profile contribute to increased cardio-vascular risk in the general population. In the current study, we test the hypothesis that kidney transplantation is associated with ab-normalities in FA profile. The FA profile was analyzed by gas chromatography–mass spectrometry in 198 renal transplant recipients, and 48 control subjects. The most profound differences between renal transplant patients and controls were related to the content of branched chain FA, monounsaturated FA, and n-6 polyunsaturated FA, respectively. The FA profile significantly separated the patients from the controls in the principal component analysis (PCA). The abnormalities of FA profile showed a tendency for normalization in long-term kidney recipients, as compared to patients with recent transplants. The n-3 PUFA content demonstrated a strong inverse association with the presence of inflammation. Most profound alterations of the FA profile were observed in patients with impaired graft function (glomerular filtration rate < 45 mL/min). The study demonstrated significant disorders of the FA profile in kidney transplant recipients, which might contribute to cardio-vascular risk in this vulnerable patient population.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

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Analysis of Serum Fatty Acids Profile in Kidney Transplant Recipients

et al. 2021

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“…In our previous studies, we observed that despite normal kidney function after transplantation, the FA profile was still abnormal [19]. Our recent work concerning a comparison of FA profiles in patients at different time intervals after transplantation and healthy controls showed many differences in FA profiles [20].…”

Section: Introductionmentioning

confidence: 94%

The Impact of Kidney Transplantation on the Serum Fatty Acid Profile in Patients with End-Stage Kidney Disease

et al. 2022

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Epidemiological data indicate that metabolic disturbances and increased cardiovascular risk in renal transplant patients are a significant and common problem. Therefore, it is important to search for new solutions and, at the same time, counteract the negative effects of currently used therapies. In this study, we examined the effect of kidney transplantation on the serum levels of fatty acids (FAs) in order to assess the role of these compounds in the health of transplant patients. The FA profile was analyzed by gas chromatography-mass spectrometry in the serum of 35 kidney transplant recipients, just before transplantation and 3 months later. The content of total n-3 polyunsaturated FAs (PUFAs) decreased after transplantation (3.06 ± 0.13% vs. 2.66 ± 0.14%; p < 0.05). The total amount of ultra-long-chain FAs containing 26 and more carbon atoms was significantly reduced (0.08 ± 0.009% vs. 0.05 ± 0.007%; p < 0.05). The desaturation index (18:1/18:0) increased after transplantation (3.92 ± 0.11% vs. 4.36 ± 0.18%; p < 0.05). The study showed a significant reduction in n-3 PUFAs in renal transplant recipients 3 months after transplantation, which may contribute to increased cardiovascular risk in this patient population.

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“…Two studies that originally met the inclusion criteria (Heemskerk et al., 2015; Sikorska‐Wisniewska et al., 2020) were excluded from further review, as they reported implausibly low ALA concentrations in AT that could also not be explained by the authors upon contacting them.…”

Section: Assessmentmentioning

confidence: 99%

Statement on additional scientific evidence in relation to the essential composition of total diet replacement for weight control

Nutrition¹,

Castenmiller²,

Henauw³

et al. 2021

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Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to revise the Opinion on the essential composition of total diet replacements for weight control (TDRs) regarding the minimum content of linoleic acid (LA) and alpha‐linolenic acid (ALA) and the maximum content of magnesium (Mg). Through a comprehensive literature search, human studies were retrieved reporting on LA and ALA concentrations in adipose tissue (AT), on weight loss and gallstone formation following TDR consumption and on diarrhoea after supplemental Mg intake. The distribution of the amount of LA and ALA release from AT during weight loss when consuming TDRs was estimated using statistical simulations. Using the fifth percentile, the coverage of the adequate intake (AI) for both FA was estimated. For the risk of developing diarrhoea when consuming TDRs with an Mg content of 350 mg/day, four cross‐over studies using 360–368 mg Mg/day were reviewed. The Panel concludes that (1) there is no need to add LA to TDRs, as the amount released from AT during weight loss when consuming TDRs is sufficient to cover the AI for LA; (2) a minimum of 0.8 g/day ALA is needed in TDRs in order to meet the AI for ALA; (3) the minimum fat content of TDRs of 20 g/day as derived in the Panel's previous opinion is proposed to be maintained until the availability of further evidence, given the considerable uncertainty as to the amount of fat required for reducing the risk of gallstone formation; and (4) the likelihood that Mg‐induced diarrhoea occurs at a severity that may be considered of concern for overweight and obese individuals consuming TDRs is low when the total maximum Mg content in TDRs is 350 mg/day.

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Disorders of Serum Polyunsaturated Fatty Acids in Renal Transplant Patients

Cited by 3 publications

References 27 publications

Analysis of Serum Fatty Acids Profile in Kidney Transplant Recipients

Analysis of Serum Fatty Acids Profile in Kidney Transplant Recipients

The Impact of Kidney Transplantation on the Serum Fatty Acid Profile in Patients with End-Stage Kidney Disease

Statement on additional scientific evidence in relation to the essential composition of total diet replacement for weight control

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