Disorders of neuromuscular transmission other than myasthenia gravis

Swift, Thomas R.

doi:10.1002/mus.880040410

Cited by 62 publications

(6 citation statements)

References 207 publications

(13 reference statements)

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“…RNS produced preand postexercise decrement of the biceps muscle. Denys and Norris' using subcutaneous hypothenar electrodes demonstrated distal decremental patterns in ALS but the exact number of cases above thies.3,5,1 [1][2][3][4][5][6][7][8][9][10][11][12][13]17,24,26 5% and 10% was not given. Applying our standards of RNS decrement to their data in 30 cases showed 20% in the borderline and 20% with definite decremental responses.…”

Section: Discussionmentioning

confidence: 98%

Decremental motor responses to repetitive nerve stimulation in ALS

et al. 1994

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Repetitive nerve stimulation (RNS) of the trapezius muscle at slow rates was performed on 192 patients with amyotrophic lateral sclerosis (ALS). Fifty-six patients (29%) showed classical neuromuscular decrement of 10-43% (mean 16.8%) while 44 patients (23%) had a borderline decrement of 5-9%. The trapezius was significantly more sensitive in revealing the defect than the distal hypothenar muscles. In 30 patients followed serially, the decremental response remained constant or increased with time. However, 25% of patients continued to show no decrement in spite of progression of disease. No statistical correlation was found between decrement and clinical severity, disease staging, or disease progression. The finding that at least 50% of ALS patients show some degree of decrement on RNS of the trapezius muscle suggests that functional alterations of the neuromuscular junction accompany this disease.

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Section: Discussionmentioning

confidence: 98%

Decremental motor responses to repetitive nerve stimulation in ALS

et al. 1994

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“…The resulting clinical picture resembles naturally occurring MG. Respiratory weakness may occur early and be severe. 51 ACTH and high doses of prednisone when used in MG may decrease muscle strength during the first few days, followed by partial or complete remission. MG can be "reproduced" by d-penicillamine.…”

Section: Drugs and Toxins Causing Disordered Neuromuscular Transmissionmentioning

confidence: 97%

Signs and Symptoms of Acute Neuromuscular Diseases Seen in the Emergency Room

Streib¹

1983

Semin Neurol

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“…More than 30 drugs in current clinical use may interfere with neuromuscular transmission alone, among them antibiotics such as neomycin, streptomycin, certain tetracyclines [110,111], and immunosuppressant agents such as adrenocorticotropic hormone (corticotropin), prednisone, and azathioprine [ 112,113]. Antipsychotic drugs may produce extrapyramidal symptoms of the parkinsonian type or muscle spasm and dystonia [114], or drugs may unmask a latent neuromuscular disease [ 112]. This may result from either a presynaptic local anesthetic-like action, a postsynaptic receptor block, a combination of both of these, or by interference with muscle-membrane conductance.…”

Section: Medications Associated With Myasthenia/myopathy/neuropathymentioning

confidence: 98%

Dysphagia in systemic disease

1993

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Dysphagia, difficulty in swallowing sometimes accompanied by a sensation of food sticking, is a common symptom resulting from structural and/or motility disorders of the oropharynx and esophagus which may result from local factors or occur as one of the manifestations of a systemic disease process. In this review, "systemic disease" will include diseases that affect more than one organ or organ system in the body such as scleroderma or Crohn's disease; skin disorders such as epidermolysis bullosa dystrophica and benign mucosal pemphigoid; hematological disorders such as amyloid and irondeficiency anemia; connective tissue disorders such as rheumatoid arthritis, dermatomyositis, polymyositis, and mixed connective tissue disorder; metabolic and endocrine disorders such as diabetes mellitus, sarcoidosis, and the Eaton-Lambert syndrome; and the immune-compromised host, and finally medications will all be addressed.The discussion will specifically exclude diseases that produce dysphagia by local inflammation (such as erosive esophagitis due to gastroesophageal reflux) or local infiltration (such as pharyngeal or esophageal carcinoma). Similarly, diseases which affect specific areas of the brain (such as a cerebrovascular accident or brain tumor) will be excluded as will neuromuscular diseases such as myasthenia gravis and amyotrophic lateral sclerosis.

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Disorders of neuromuscular transmission other than myasthenia gravis

Cited by 62 publications

References 207 publications

Decremental motor responses to repetitive nerve stimulation in ALS

Decremental motor responses to repetitive nerve stimulation in ALS

Signs and Symptoms of Acute Neuromuscular Diseases Seen in the Emergency Room

Dysphagia in systemic disease

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