Disorders of menstruation and their effect on the quality of life in women with congenital factor VII deficiency

Kulkarni, Ashwini; Lee, C. A.; Griffeon, Anja; Kadir, Rezan A.

doi:10.1111/j.1365-2516.2006.01219.x

Cited by 29 publications

(62 citation statements)

References 12 publications

(18 reference statements)

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“…Over one‐third of the women had to cut down time spent on work, 40% took extra effort to perform their work and 47% accomplished less during menstruation. Similarly, in FVII deficiency, QOL during menstruation has been shown to be significantly poorer than in age‐matched controls [6], 71% of the women accomplished less than they would like and 86% had to cut down the amount of time spent on work during menstruation. In a recent study from the same centre, adolescents with inherited bleeding disorders had a poorer QOL score compared with women with inherited bleeding disorders with median scores of 40 (range 15–60) and 47 (range 27–60), respectively [20].…”

Section: Methodsmentioning

confidence: 99%

The impact of menstrual disorders on quality of life in women with inherited bleeding disorders

2010

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Menorrhagia, heavy menstrual bleeding, is a common condition that has a substantial impact on the lives of many women. The objective measurement of menorrhagia is often impractical; therefore diagnosis and treatment are usually based on the direct perception of the woman. Menstrual problems are likely to be worse in women with bleeding disorders, as they are more likely to have heavy and painful menstrual periods and ovulation bleeding and pain. These can have a major impact on the quality of women's lives, especially those who suffer heavy menstruation. These problems can also lead to limitations at work and school and hinder educational and academic achievements. Only few studies describe how quality of life (QOL) changes in women with an underlying haemostatic defect; poorer QOL being associated with more frequent bleeding symptoms. Early recognition, accurate diagnosis and appropriate management of bleeding disorders should improve not only the quality of care for affected women but also their QOL. Increased awareness of the high prevalence of menstrual problems especially menorrhagia is essential for early diagnosis and provision of appropriate treatments without any delay. Accurate knowledge of the impact of menorrhagia on health-related quality of life (HRQOL) and its adequate assessment help individualize treatment and assess the magnitude of changes in HRQOL. An ideal situation would be to use a generic and a disease-specific measure together so that comparisons can be made on a general and disease-specific level.

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Section: Methodsmentioning

confidence: 99%

The impact of menstrual disorders on quality of life in women with inherited bleeding disorders

2010

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“…Heavy menstrual bleeding in women with inherited bleeding disorders should be managed with a multidisciplinary approach, based also on the objective of preserving fertility [41]. Other medical therapies of menorrhagia includes hemostatic agents like tranexamic acid and hormonal treatments (combined oral contraceptives, levonorgestrel intrauterine devices), in combination or not with RT [42]. Progesterone-releasing intra-uterine systems can be effective in suppressing ovulation, thereby reducing the risk of bleeding in these women.…”

Section: Replacement Therapymentioning

confidence: 99%

Factor VII Deficiency: Clinical Phenotype, Genotype and Therapy

Napolitano

Siragusa

Mariani

2017

JCM

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Factor VII deficiency is the most common among rare inherited autosomal recessive bleeding disorders, and is a chameleon disease due to the lack of a direct correlation between plasma levels of coagulation Factor VII and bleeding manifestations. Clinical phenotypes range from asymptomatic condition—even in homozygous subjects—to severe life-threatening bleedings (central nervous system, gastrointestinal bleeding). Prediction of bleeding risk is thus based on multiple parameters that challenge disease management. Spontaneous or surgical bleedings require accurate treatment schedules, and patients at high risk of severe hemorrhages may need prophylaxis from childhood onwards. The aim of the current review is to depict an updated summary of clinical phenotype, laboratory diagnosis, and treatment of inherited Factor VII deficiency.

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“…Menorrhagia is the most common bleeding symptom in women of reproductive age with ARBDs [3][4][5][6][7][8], represents a very frequent cause of iron deficiency [1,3,6,9-12] and carries a high negative impact on the quality of life [2,7]. Furthermore, other frequent gynaecological problems, such as uterine fibroids, are more likely to be symptomatic because of the increased bleeding tendency.…”

Section: Introductionmentioning

confidence: 99%

Women with congenital factor VII deficiency: clinical phenotype and treatment options from two international studies

et al. 2016

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Disorders of menstruation and their effect on the quality of life in women with congenital factor VII deficiency

Abstract: Women with factor VII deficiency exhibit a spectrum of bleeding symptoms, menorrhagia being one of the commonest symptoms. This has adverse effect on their quality of life.

Cited by 29 publications

References 12 publications

The impact of menstrual disorders on quality of life in women with inherited bleeding disorders

The impact of menstrual disorders on quality of life in women with inherited bleeding disorders

Factor VII Deficiency: Clinical Phenotype, Genotype and Therapy

Women with congenital factor VII deficiency: clinical phenotype and treatment options from two international studies

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