DISORDERS OF A MICROBIOCENOSIS OF INTESTINES AT PATIENTS WITH A COLORECTAL CANCER AND WAYS OF THEIR CORRECTION (review)

Abstract

Patients with colorectal cancer in the perioperative period, revealed pronounced changes of microbiocenosis of colon, which is characterized by changes in the quantitative and qualitative composition of microflora. It showed a significant inhibition of anaerobic microbial component mainly bifidobacteria and lactobacilli. As a result, saprophytic microbes multiply with highly resistant to drugs, acquire pathogenic properties. The most prominent representative of such microorganisms is a pathogenic strain of Clostridium difficile, often provokes the development of pseudomembranous colitis. Depending on the degree of dysbiosis held various schemes of conservative therapy, and in severe dysbiotic changes, including pronounced diarrhea associated Clostridium dificile -fecal transplantation.

Gut microbiota in the combined treatment of colorectal cancer using autoprobiotics

“…Применение пробиотиков целесообразно в процессе лечения больных КРР на всех этапах: в периоперационном и в отдаленном послеоперационном периоде, на фоне использования облучения и введения цитостатиков, так как все указанные традиционные способы терапии оказывают отрицательное воздействие на организм, одним из которых является усугубление дисбиоза кишечника [ 28,[31][32]. В ряде случаев недостаточная эффективность пробиотиков, быстрое выведение из организма, побочные эффекты, связанные с их приемом: ацидоз, диспепсия, инфекционные осложнения [33][34] обусловили поиск альтернативных методов коррекции клиниколабораторных показателей при КРР.…”

Autoprobiotics in the Treatment of Patients with Colorectal Cancer in the Early Postoperative Period

“…Surgical intervention, coupled with the administration of antibacterial drugs, typically results in more pronounced consequences, as evidenced by significant alterations in clinical and laboratory parameters, along with shifts in microbiota composition. These changes set the stage for severe complications, including but not limited to abdominal sepsis, pseudomembranous colitis, antibiotic-associated dysbiosis, and colitis [19,20].…”

“…According to the literature data, the intake of probiotics is recommended in the complex treatment of CRC patients across all stages, encompassing the perioperative and longterm postoperative periods, as well as during and after chemoradiotherapy. Traditional therapeutic modalities, including surgery and chemoradiotherapy, exert deleterious effects on the body, notably contributing to the exacerbation of gut dysbiosis [19,20,27]. Nevertheless, in instances where probiotics exhibit insufficient efficacy, rapid elimination from the gut, or lead to side effects such as acidosis, dyspepsia, and infectious complications [28], alternative methods for rectifying clinical and laboratory parameters in CRC have been found.…”