Disorders at the Testicular Level

Nieschlag, Eberhard; Behre, Hermann M.; Wieacker, Peter; Meschede, Dieter; Kamischke, Axel; Kliesch, Sabine

doi:10.1007/978-3-540-78355-8_13

Cited by 34 publications

(22 citation statements)

References 190 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The incidence of cryptorchidism is 1-4% in human male neonates (Toppari et al, 2001). The cause of cryptorchidism is multifactorial, although possible causes and risk factors, such as endocrine disorders, anatomical abnormalities and environmental and genetic factors, can explain the etiology of this phenomenon (Nieschalag et al, 2000).…”

Section: Epididymal Abnormalities In Cryptorchidismmentioning

confidence: 99%

“…Alterations in temperature also affect the ionic and protein composition of the cauda fluid, which effects the cauda epithelium by eliminating the special ability of the cauda to store and prolong the life of spermatozoa through the promotion of rapid epididymal transport (Nieschalag et al, 2000). In a series of studies on the epididymides of cryptorchidic animals and on primary epithelial cell cultures, it was shown that some epididymal gene products are exquisitely sensitive to small changes in temperature (Kirchhoff et al, 2000).…”

Section: Epididymal Abnormalities In Cryptorchidismmentioning

confidence: 99%

See 1 more Smart Citation

The Epididymis: Embryology, Structure, Function And Its Role In Fertilization And Infertility

Arroteia¹,

García²,

Barbieri³

et al. 2012

Embryology - Updates and Highlights on Classic Topics

View full text Add to dashboard Cite

Embryology is a branch of science concerned with the morphological aspects of organismal development. The genomic and molecular revolution of the second half of the 20th century, together with the classic descriptive aspects of this science have allowed greater integration in our understanding of many developmental events. Through such integration, modern embryology seeks to provide practical knowledge that can be applied to assisted reproduction, stem cell therapy, birth defects, fetal surgery and other fields. This book focuses on human embryology and aims to provide an up-to-date source of information on a variety of selected topics. The book consists of nine chapters organized into three sections, namely: 1) gametes and infertility, 2) implantation, placentation and early development, and 3) perspectives in embryology. The contents of this book should be of interest to biology and medical students, clinical embryologists, laboratory researchers, obstetricians and urologists, developmental biologists, molecular geneticists and anyone who wishes to know more about recent advances in human development.

show abstract

Section: Epididymal Abnormalities In Cryptorchidismmentioning

confidence: 99%

Section: Epididymal Abnormalities In Cryptorchidismmentioning

confidence: 99%

The Epididymis: Embryology, Structure, Function And Its Role In Fertilization And Infertility

Arroteia¹,

García²,

Barbieri³

et al. 2012

Embryology - Updates and Highlights on Classic Topics

View full text Add to dashboard Cite

show abstract

“…Controversy still remains regarding the benefit of varicocele repair to improve male fertility Evers et al, 2009;Nieschlag et al, 2010;Jungwirth et al, 2013). Evidence exists both in favour and against it, but as of now, most of specialty societies recognize that varicocele is detrimental to male reproductive health and its treatment may improve sperm function and chances of conceiving Baazeem et al, 2011;Ficarra et al, 2012;Kroese et al, 2012;Lopushnyan & Walsh, 2012;Miyaoka & Esteves, 2012;Kim et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

“…The autoimmune reactions against the spermatozoa with the antisperm antibodies (ASA) production are one of the causes of infertility in men (WHO, 2000;Walsh & Turek, 2009;Nieschlag et al, 2010;Wiser et al, 2012). The ASA cause the sperm agglutination and decrease its motility as well as impair the sperm penetration into cervical mucus and hinder the fertilization of the ovum; the ASA can affect the fetal early development, implantation and gestation course (Mazumdar & Levine, 1998;Francavilla & Barbonetti, 2009;Krause, 2009;Walsh & Turek, 2009;Check, 2010).…”

Section: Introductionmentioning

confidence: 99%

The role of the antisperm antibodies in male infertility assessment after microsurgical varicocelectomy

et al. 2014

View full text Add to dashboard Cite

SUMMARYAntisperm antibodies (ASA) are a cause of male infertility. ASA are often found in varicocele patients. The study objective was to assess the ASA role in fertility recovery after varicocelectomy. The longitudinal study involved 99 patients with varicocele. Patients were examined according to the WHO recommendations; ASA level was measured using the direct method of Sperm MAR test: 66 patients were ASA-negative, 33 had MAR-IgG ≥ 10%. All patients underwent microsurgical varicocelectomy. Student's t-test, Wilcoxon test, Chi-squared test and signed rank test were used for data analysis. The retrospective analysis of all operated patients data showed that the patients without spermiogram improvement after varicocelectomy had higher ASA levels. 3 months after the surgery, the initially ASA-negative varicocele patients demonstrated 2.5 times increase in number of progressive motile spermatozoa in the ejaculate (p < 0.001), accompanied by 6% decrease in abnormal sperm count (p < 0.05); the spermiogram parameters improved in 77% of cases (p < 0.01). After the surgery, ASA developed in 16% of cases (Max -MAR-IgG = 12%). The patients who were initially ASA-positive demonstrated ASA decrease only in half of the cases (16 of 33; p > 0.05). The main outcome in this group was a favourable response to the surgery (ASA level decrease) vs. no reduction in autoimmune process. The improvement in the ASA-positive group was demonstrated in the patients with higher varicocele grade (median -2 vs. 1; p < 0.05) and lower ASA level (MARIgG = 48% vs. 92%; p < 0.01). The pregnancy rate within a year after surgery was 2.8 times more frequent in couples with ASA-negative men: 39% (25 of 65) in the ASA-negative group compared to 14% (4 of 28) in the ASA-positive group (p < 0.05). Thus, antisperm immune response decreases the varicocelectomy efficacy for reproductive function recovery: the higher percentage of ASA and lower grade of varicocele are associated with an unfavourable prognosis.

show abstract

“…Repeated biopsies are sometimes performed to obtain sperm for ICSI, to evaluate a testicular tumor, or to detect histological changes because of the progression of hypospermatogenesis [11,32].…”

Section: Resultsmentioning

confidence: 99%

Biopsy and vascularization: testicular tissue removal and prevention of hemorrhagies related to the main vessels

Deh¹,

Ajl²,

Mf³

et al. 2018

J Histol Histopathol

View full text Add to dashboard Cite

Purpose: the objective of the work is to determine the testicular regions favorable for the realization of a testicular biopsy without damaging the important vessels. Material and Methods: 8 left and right testes were collected from 3 immature Wistar rats and 1 adult control, aged 15, 25 and 40 days for the young rats and 7 months for the adult. The testes were taken under inhalation anesthesia. The testes were examined by eye and the images were obtained from a digital camera. Results: Results showed that the testicular (or spermatic) artery with a large caliber had a subcapsular arrangement. It was tortuous and followed the anterior edge of the testicle from the upper pole to the lower pole. As that vessel passed along this place it formed an arterial handle and ascended along the posterior edge. The arrangement of this artery was identical for all populations of rats. Very small vessels were observed beneath the internal surface of the albuginea of the testis mainly from the lateral areas of the testis. They had transverse, horizontal and oblique directions and which intensified with the age of the animals. Conclusion: Anatomically, the results of this study highlight the situation and caliber variability of the superficial vessels of the testis and the importance of the testicular artery. Clinically, they could be useful for testicular biopsy, we suggest that it be practiced away from the large vessels, that is to say in the lateral areas of the testicle.

show abstract

Disorders at the Testicular Level

Cited by 34 publications

References 190 publications

The Epididymis: Embryology, Structure, Function And Its Role In Fertilization And Infertility

The Epididymis: Embryology, Structure, Function And Its Role In Fertilization And Infertility

The role of the antisperm antibodies in male infertility assessment after microsurgical varicocelectomy

Biopsy and vascularization: testicular tissue removal and prevention of hemorrhagies related to the main vessels

Contact Info

Product

Resources

About