Disordered Topography Mediates Filopodial Extension and Morphology of Cells on Stiff Materials

Abstract

Figure 5. C) Dependence of the average filopodial extension velocity on the adhesion strength γ and surface roughness. α here represents the shrinking factor with α = 1 corresponding to the initial MCD topography. Error bar here indicates the standard deviation of simulation results from eight different MCD topographies. For comparison, the measured speeds of growing filopodia on MCD and NCD substrates are also given by the purple and blue cross markers (assuming γ = 9 × 10 −5 J m −2 ), respectively.The above error does not affect the scientific conclusions drawn from the work. The authors apologize for any inconvenience or misunderstanding that this error may have caused. correction

Capsule-Integrated Polypeptide Multilayer Films for Effective pH-Responsive Multiple Drug Co-Delivery

“…The deposition of microcapsules led to an obvious increase in surface roughness, indicating a desirable topography to enhance the cell-material interactions for clinical applications. 11,47,48…”

Pinecone‐Inspired Nanoarchitectured Smart Microcages Enable Nano/Microparticle Drug Delivery

“…[11] Further atomic force microscopy (AFM) analyses indicated that, in contrast to the smooth PL layer ( Figure S1e, Supporting Information), the incorporation of CNFs led to an obvious increase in surface roughness from 2-5 to 10-50 nm (Figure 1f), showing a topography that can enhance cell-material interactions for clinical applications. [34,35] Our unique pinecone-inspired design allowed the microcages to possess remarkable loading capability with drug size >100 nm, more than ten times higher than that of the control polymer capsules (Figure 1g). Meanwhile, both their mechanical property and hydrophilicity were greatly enhanced compared to the control capsules (>150% improved compressive strength and from hydrophilic to superhydrophilic; Figure 1h,i).…”

Nanostructured akermanite glass-ceramic coating on Ti6Al4V for orthopedic applications

“…35 Disordered topography, as is the case for most biological tissue and almost all clinically accepted biomaterials, is reported to highly affect the morphology of osteoblast cells. 36 Figures 5 and 6 shows the OM and SEM micrographs representing the morphology of Saos-2 cells cultured on coated and uncoated samples after 3 days in culture. The cells cultured on the coated surface represent a rather flat morphology whereas the cultures on uncoated samples represent a more rounded configuration.…”