2024
DOI: 10.1101/2024.06.21.600094
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Disordered regions of human eIF4B orchestrate a dynamic self-association landscape

Bikash Chandra Swain,
Pascale Sarkis,
Vanessa Ung
et al.

Abstract: Eukaryotic translation initiation factor eIF4B is required for efficient cap-dependent translation, it is overexpressed in cancer cells, and may influence stress granule formation. Due to the high degree of intrinsic disorder, eIF4B is rarely observed in cryo-EM structures of translation complexes and only ever by its single structured RNA recognition motif domain, leaving the molecular details of its large intrinsically disordered region (IDR) unknown. By integrating experiments and simulations we demonstrate… Show more

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