Disordered clock protein interactions and charge blocks turn an hourglass into a persistent circadian oscillator
Meaghan S. Jankowski,
Daniel Griffith,
Divya G. Shastry
et al.
Abstract:Organismal physiology is widely regulated by the molecular circadian clock, a feedback loop composed of protein complexes whose members are enriched in intrinsically disordered regions. These regions can mediate protein-protein interactions via SLiMs, but the contribution of these disordered regions to clock protein interactions had not been elucidated. To determine the functionality of these disordered regions, we applied a synthetic peptide microarray approach to the disordered clock protein FRQ in Neurospor… Show more
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