Disorder- and emotional context-specific neurofunctional alterations during inhibitory control in generalized anxiety and major depressive disorder

Liu, Congcong; Dai, Jing; Chen, Yuanshu; Qi, Ziyu; Xin, Fei; Zhuang, Qian; Zhou, Xinqi; Zhou, Feng; Luo, Li; Huang, Yulan; Wang, Jinyu; Zou, Zhili; Chen, Huafu; Kendrick, Keith M.; Xu, Xiaoling; Becker, Benjamin

doi:10.1016/j.nicl.2021.102661

Cited by 20 publications

(17 citation statements)

References 57 publications

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“…Notably, both GAD and MDD exhibited smaller GMV in the mPFC in comparison to 13 FAD. fMRI studies have shown common neurofunctional alterations in the mPFC and ACC in cognitive or emotional processing in both GAD and MDD (17)(18)(19). Previous metaanalyses have identified altered volume in mPFC in GAD (22), MDD (26), and individuals with high neuroticism (48), a pathological meta-factor associated with GAD and MDD which share symptomatic (e.g., negative affect, worry) (4) and genetic etiologies (5).…”

Section: Discussionmentioning

confidence: 99%

“…While the segregation has been translated into the Acute Threat (fear) and Potential Threat (Anxiety) domains of the Research Domain Criteria (RDoC) (12), accumulating findings indicate a shared neural basis anxiety, fear and general negative affect (13,14). Shared and distinct neurobiological systems underlying these pathological domains have been revealed by functional magnetic resonance imaging (fMRI) studies comparing GAD and FAD (15,16), as well as GAD and MDD during emotional and cognitive processing (17)(18)(19) or by case-control studies examining brain structural alterations using structural MRI (sMRI) in single diagnostic categories (20). However, results have been dependent on the specific task-domain and population examined and conclusions have been limited by small sample sizes and analytic variability (21).…”

Section: Introductionmentioning

confidence: 99%

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Distinct neurostructural signatures of anxiety-, fear-related and depressive disorders: a comparative voxel-based meta-analysis

Liu

Klugah‐Brown

Zhang

et al. 2021

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Internalizing disorders encompass anxiety, fear and depressive disorders. While the DSM-5 nosology conceptualizes anxiety and fear-related disorders as an entity, dimensional psychopathology models suggest that generalized anxiety disorders (GAD) and major depression originate from an overarching “anxious-misery” factor whereas fear-related disorders originate from the “fear” factor. Given that a neurobiological evaluation is lacking, we conducted a comparative neuroimaging meta-analysis of gray matter volume alterations to determine common and disorder-specific brain structural signatures in these disorders. The PubMed, Web of Knowledge, and Scopus databases were searched for case-control voxel-based morphometric studies through December, 2020 in GAD, fear-related anxiety disorders (FAD, i.e., social anxiety disorders, SAD; specific phobias, SP; panic disorders, PD; and agoraphobia, AG) and major depressive disorder (MDD). Neurostructural abnormalities were assessed within each disorder group followed by quantitative comparison and conjunction analyses using Seed-based d-Mapping (SDM-PSI). GAD (9 studies, 226 patients) showed disorder-specific decreased volumes in left insula (z=-2.98, pFWE-corrected<0.05) and lateral/medial prefrontal cortex (z=-2.10, pFWE-corrected<0.05,) as well as increased right putamen volume (z=1.86, pFWE-corrected<0.05) relative to FAD (10 SAD, 11 PD, 2 SP studies, 918 patients). Both GAD and MDD (46 studies, 2,575 patients) exhibited decreased prefrontal volumes compared to controls and FAD. While FAD showed less robust alterations in lingual gyrus (p < 0.0025, uncorrected), this group presented intact frontal integrity. No shared structural abnormalities were found. Unique clinical features characterizing anxiety-, fear-related and depressive disorders are reflected by disorder-specific neuroanatomical abnormalities. Targeting the disorder-specific neurostructural signatures could improve therapeutic efficacy.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Distinct neurostructural signatures of anxiety-, fear-related and depressive disorders: a comparative voxel-based meta-analysis

Liu

Klugah‐Brown

Zhang

et al. 2021

Preprint

Self Cite

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“…Symptomatic and epidemiological perspectives suggest that generalized anxiety disorder (GAD) and major depressive disorder (MDD) share symptoms of general affective distress and exhibit high rates of co-morbidity (70-90% lifetime comorbidity) leading to ongoing debates about common and distinct neurobiological bases (Maron and Nutt, 2017). Determining disorder-specific neural alterations in GAD and MDD can help understanding of the pathogenesis of these disorders and inform the development of more efficient interventions (MacNamara et al, 2017; Liu et al, 2021). An increasing number of studies have therefore adopted a transdiagnostic neuroimaging approach employing a direct comparison between GAD and MDD in order to determine common and disorder-specific neural alterations.…”

Section: Introductionmentioning

confidence: 99%

Opposing and emotion-specific frontal alterations during facial emotion processing in generalized anxiety and depression

Chen

Liu

Xin

et al. 2022

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Background: Major depression (MDD) and generalized anxiety disorder (GAD) have become one of the leading global causes of disability and both are characterized by marked interpersonal and social impairments. However, despite a high comorbidity and overlapping social-emotional deficits it remains unclear whether MDD and GAD share a common neural basis during interpersonal processing. Methods: This study combined an emotional face processing paradigm with fMRI and dimensional and categorical analyses in a sample of unmedicated MDD and GAD patients (N = 72) as well as healthy controls (N = 35). Results: No group differences were found in categorical analyses. However, the dimensional analyses revealed that dorsolateral prefrontal cortex (dlPFC) reactivity to sad facial expressions was positively associated with depressive, yet negatively associated with GAD symptom load in the entire sample. On the network level depression symptom load was positively associated with functional connectivity between the bilateral amygdala and a widespread network including the anterior cingulate and insular cortex. Limitations: Sex differences were not examined in the present study and some patients exhibited depression-GAD comorbidity. Conclusions: Together, these findings suggest that the dlPFC - engaged in cognitive and emotional processing - exhibits symptom- and emotion-specific alteration during interpersonal processing. Dysregulated communication between amygdala and core regions of the salience network may represent MDD-specific neural dysregulations.

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“…Generally, the clinical symptoms of anxiety and depression are different. However, they are frequently presented simultaneously (Liu et al, 2021;Thorp et al, 2021). Importantly, there are lots of overlaps with respect of the pathophysiology and comorbidity of these two disorders.…”

Section: Introductionmentioning

confidence: 99%

Proteomic Response of Rat Pituitary Under Chronic Mild Stress Reveals Insights Into Vulnerability and Resistance to Anxiety or Depression

et al. 2021

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Chronic stress as one of the most significant risk factor can trigger overactivity of hypothalamic-pituitary-adrenal (HPA) axis in depression as well as anxiety. Yet, the shared and unique neurobiological underpinnings underlying the pituitary abnormality in these two disorders have not been made clear. We previously have established depression-susceptible, anxiety-susceptible and insusceptible groups using a valid chronic mild stress (CMS) model. In this work, the possible protein expression changes in the rat pituitary of these three groups were continuously investigated through the use of the comparative quantitative proteomics and bioinformatics approaches. The pituitary-proteome analysis identified totally 197 differential proteins as a CMS response. These deregulated proteins were involved in diverse biological functions and significant pathways potentially connected with the three different behavioral phenotypes, likely serving as new investigative protein targets. Afterwards, parallel reaction monitoring-based independent analysis found out that expression alterations in Oxct1, Sec24c, Ppp1cb, Dock1, and Coq3; Lama1, Glb1, Gapdh, Sccpdh, and Renbp; Sephs1, Nup188, Spp1, Prodh1, and Srm were specifically linked to depression-susceptible, anxiety-susceptible and insusceptible groups, respectively, suggesting that the same CMS had different impacts on the pituitary protein regulatory system. Collectively, the current proteomics research elucidated an important molecular basis and furnished new valuable insights into neurochemical commonalities and specificities of the pituitary dysfunctional mechanisms in HPA axis underlying vulnerability and resistance to stress-induced anxiety or depression.

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Disorder- and emotional context-specific neurofunctional alterations during inhibitory control in generalized anxiety and major depressive disorder

Cited by 20 publications

References 57 publications

Distinct neurostructural signatures of anxiety-, fear-related and depressive disorders: a comparative voxel-based meta-analysis

Distinct neurostructural signatures of anxiety-, fear-related and depressive disorders: a comparative voxel-based meta-analysis

Opposing and emotion-specific frontal alterations during facial emotion processing in generalized anxiety and depression

Proteomic Response of Rat Pituitary Under Chronic Mild Stress Reveals Insights Into Vulnerability and Resistance to Anxiety or Depression

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