Disorder- and cognitive demand-specific neurofunctional alterations during social emotional working memory in generalized anxiety disorder and major depressive disorder

Xu, Xiaoling; Xin, Fei; Liu, Congcong; Chen, Yuanshu; Yao, Shuxia; Zhou, Xinqi; Zhou, Feng; Huang, Yulan; Dai, Jing; Wang, Jinyu; Zou, Zhili; Kendrick, Keith M.; Zhou, Bo; Becker, Benjamin

doi:10.1016/j.jad.2022.04.023

Cited by 7 publications

(2 citation statements)

References 77 publications

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“…The function of the dlPFC and dmPFC should be discussed in detail. Metacognitive monitoring studies have shown that the dlPFC and dmPFC are key brain regions when making metacognitive monitoring judgments 13 , 14 , 29 , 36 , 37 , while executive function studies suggest that the dlPFC and dmPFC are involved in working memory processes 52 , 53 . Using the JOLs paradigm and MVPA analysis, we found that the dlPFC and dmPFC are correlated with metacognitive monitoring, and the SMG represents the working memory process, indicating different neural mechanisms between metacognitive monitoring and working memory.…”

Section: Discussionmentioning

confidence: 99%

Elucidating the underlying components of metacognitive systematic bias in the human dorsolateral prefrontal cortex and inferior parietal cortex

Cong,

Long,

Zhang

et al. 2024

Sci Rep

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Metacognitive systematic bias impairs human learning efficiency, which is characterized by the inconsistency between predicted and actual memory performance. However, the underlying mechanism of metacognitive systematic bias remains unclear in existing studies. In this study, we utilized judgments of learning task in human participants to compare the neural mechanism difference in metacognitive systematic bias. Participants encoded words in fMRI sessions that would be tested later. Immediately after encoding each item, participants predicted how likely they would remember it. Multivariate analyses on fMRI data demonstrated that working memory and uncertainty decisions are represented in patterns of neural activity in metacognitive systematic bias. The available information participants used led to overestimated bias and underestimated bias. Effective connectivity analyses further indicate that information about the metacognitive systematic bias is represented in the dorsolateral prefrontal cortex and inferior parietal cortex. Different neural patterns were found underlying overestimated bias and underestimated bias. Specifically, connectivity regions with the dorsolateral prefrontal cortex, anterior cingulate cortex, and supramarginal gyrus form overestimated bias, while less regional connectivity forms underestimated bias. These findings provide a mechanistic account for the construction of metacognitive systematic bias.

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Section: Discussionmentioning

confidence: 99%

Elucidating the underlying components of metacognitive systematic bias in the human dorsolateral prefrontal cortex and inferior parietal cortex

Cong,

Long,

Zhang

et al. 2024

Sci Rep

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“…Working memory (WM) conceptualizes a cognitive system that has been referred to as the “sketchpad of conscious thought”, given its essential role in all complex cognitive processes, ranging from problem-solving and decisionmaking to social cognition and language processing. Impairments in WM have been reported in a range of neurological and mental disorders, such as Alzheimer’s and Parkinson’s disease, schizophrenia, major depression, and substance use disorders (Lee and Park 2005; Forbes et al 2009; Becker et al 2010; Jahn 2013; Wang et al 2015; Nikolin et al 2021; Ramos and Machado 2021), and have been associated with impaired social and daily life functioning (Huang et al 2014; Xu et al 2022; Sun et al 2023). WM thus represents a promising treatment target and initial studies have developed and evaluated behavioral and pharmacological interventions to enhance WM (Hernaus et al 2017; Kaser et al 2017; Teixeira-Santos et al 2019; Zhao, Becker, et al 2019; Afsaneh and Zarei Ghobadi 2022).…”

Section: Introductionmentioning

confidence: 99%

A brief real-time fNIRS-informed neurofeedback training of the prefrontal cortex changes brain activity and connectivity during subsequent working memory challenge

Yang

Zeng

Jiao

et al. 2023

Preprint

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Working memory (WM) represents a building-block of higher cognitive functions and a wide range of mental disorders are associated with WM impairments. Initial studies have shown that several sessions of functional near-infrared spectroscopy (fNIRS) informed real-time neurofeedback (NF) allow healthy individuals to volitionally increase activity in the dorsolateral prefrontal cortex (DLPFC), a region critically involved in WM. For the translation to therapeutic or neuroenhancement applications, however, it is critical to assess whether fNIRS-NF success transfers into neural and behavioral WM enhancement in the absence of feedback. We therefore combined single-session fNIRS-NF of the left DLPFC with a randomized sham-controlled design (N = 62 participants) and a subsequent WM challenge with concomitant functional MRI. Over four runs of fNIRS-NF, the left DLPFC NF training group demonstrated enhanced neural activity in this region, reflecting successful acquisition of neural self-regulation. During the subsequent WM challenge, we observed no evidence for performance differences between the training and the sham group. Importantly, however, examination of the fMRI data revealed that - compared to the sham group - the training group exhibited significantly increased regional activity in the bilateral DLPFC and decreased left DLPFC - left anterior insula functional connectivity during the WM challenge. Exploratory analyses revealed a negative association between DLPFC activity and WM reaction times in the NF group. Together, these findings indicate that healthy individuals can learn to volitionally increase left DLPFC activity in a single training session and that the training success translates into WM-related neural activation and connectivity changes in the absence of feedback. This renders fNIRS-NF as a promising and scalable WM intervention approach that could be applied to various mental disorders.

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Abnormal multi-layered dynamic cortico-subcortical functional connectivity in major depressive disorder and generalized anxiety disorder

Liu,

Zhou,

Zhang

et al. 2023

Journal of Psychiatric Research

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Disorder- and cognitive demand-specific neurofunctional alterations during social emotional working memory in generalized anxiety disorder and major depressive disorder

Cited by 7 publications

References 77 publications

Elucidating the underlying components of metacognitive systematic bias in the human dorsolateral prefrontal cortex and inferior parietal cortex

Elucidating the underlying components of metacognitive systematic bias in the human dorsolateral prefrontal cortex and inferior parietal cortex

A brief real-time fNIRS-informed neurofeedback training of the prefrontal cortex changes brain activity and connectivity during subsequent working memory challenge

Abnormal multi-layered dynamic cortico-subcortical functional connectivity in major depressive disorder and generalized anxiety disorder

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