Disoprofol (ICI 35868) for Total Intravenous Anaesthesia

Abstract

The purpose of this study was to evaluate disoprofol as the hypnotic for total intravenous anaesthesia. Sixty women undergoing minor gynaecological surgery participated and were randomly assigned to four groups (N = 15 in each group). Disoprofol, 2 mg/kg was given i.v. to induce anaesthesia after a bolus injection of either fentanyl 1.875 micrograms/kg or alfentanil 18.75 micrograms/kg. Vecuronium, 0.06 mg/kg, was given for muscle relaxation when indicated. One-half of the patients received acute premedication with midazolam, 5 mg i.v. Anaesthesia was maintained with a continuous infusion of disoprofol 150 micrograms/kg/min and either fentanyl 0.125 micrograms/kg/min or alfentanil 1.25 micrograms/kg/min. These drug combinations were compatible and produced good operating conditions. Awakening time was significantly shorter for women who received no premedication and was not affected by the narcotic used. Respiration returned more quickly when fentanyl was the narcotic given and was not affected by premedication. Both hypotension and bradycardia were seen in some patients, but other side effects were infrequent. This total intravenous anaesthesia technique was very well accepted by the patients and the nurses who cared for them in the postoperative period.

Comparison of Infusions of Propofol and Methohexitone to Provide Light General Anaesthesia During Surgery With Regional Blockade

“…anaesthetic agent to be of use by continuous infusion, it must be rapidly cleared from the body so that cumulation is minimal, thus allowing easy control of depth of anaesthesia and rapid, uncomplicated recovery. Clinical studies of theoriginalCremophorpreparationofdi-isopropyl phenol indicated that it was suitable for use in this way (Major et aJ., 1982;O'Callaghan et al, 1982;Fragen et al, 1983) and this was confirmed by the early pharmacokinetic studies (Adam, Kay and Douglas, 1982;Adam et al, 1983).…”

Propofol as a transformative drug in anesthesia: insights from key early investigators

“…Based on personal contacts, publicly available regulatory documents and searches of the medical literature for seminal articles describing the discovery and preclinical and/or early clinical testing of propofol [15][16][17][18], we identified senior contributors or experts likely to have insights into the development of propofol. Of the 16 individuals on our initial list, two did not have contact information that was readily obtainable.…”

Remifentanil Has Sufficient Hypnotic and Amnesic Effect for Induction of Anesthesia by Itself

“…The effects of opioids on cardiovascular variables are usually less when it was used without other anesthetics [17], while propofol and inhalation anesthetics suppress cardiac function and dilate vessels, and often cause hypotension [18][19][20]. In the NS group, the blood pressure did not change significantly during induction, while the heart rate after the intubation increased by 27% compared to that before the remifentanil infusion.…”