Disodium cromoglycate: a novel gastric antiulcer agent?

Ogle, C. W.; Lau, H. K.

doi:10.1016/0014-2999(79)90117-1

Cited by 28 publications

(14 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…DS-4574 as well as DSCG noteworthily suppressed both the hyperhistaminemia and histamine release from peritoneal mast cells, although there was quite a difference in the administration route and dosage levels. DSCG is thought to exert inhibitory action on reserpine-or ethanol-induced rat gastric lesions owing to its mast cell stabilizing action [17,21]. These findings thus indicate that the ant• effect of DS-4574 may involve the inhibition of mediator release.…”

Section: Discussionmentioning

confidence: 83%

See 1 more Smart Citation

Inhibitory effect of DS-4574, a peptidoleukotriene antagonist with mast cell stabilizing action, on compound 48/80-induced gastric mucosal lesions in rats

Tabuchi¹,

Kawarabayashi²,

Furuhama³

1994

Agents and Actions

View full text Add to dashboard Cite

We evaluated the inhibitory effect of DS-4574, a peptidoleukotriene antagonist with mast cell stabilizing action, on rat gastric mucosal lesions induced by compound 48/80 (C48/80: a mast cell degranulator), in comparison with those of disodium cromoglycate (DSCG: a mast cell stabilizer), LY171883 (a peptidoleukotriene antagonist) and cimetidine (a histamine H2 receptor antagonist). Subcutaneous administration of C48/80 (1 mg/kg) once daily for four consecutive days produced extensive gastric lesions in the fundic mucosa. DS-4574 (20, 50 and 100 mg/kg/day, oral) and DSCG (200 mg/kg/day, intraperitoneal) treatment markedly inhibited formation of these mucosal lesions, but LY171883 (100 and 200 mg/kg/day, oral) and cimetidine (400 mg/kg/day, oral) treatment did not. Moreover, DS-4574 and DSCG significantly suppressed both hyperhistaminemia and histamine release from rat peritoneal mast cells induced by C48/80. These results indicate that the inhibitory effect of DS-4574 on gastric lesions induced by C48/80 may be related to its mast cell stabilizing action, but to neither its antisecretory nor its peptidoleukotriene antagonistic activity.

show abstract

Section: Discussionmentioning

confidence: 83%

“…at 5 ml/kg. The administration route used in each compound was chosen on the basis of previously published reports [3,4,17]. In the in vitro study, DS-4574 and DSCG were dissolved in dimethylsulphoxide and purified water, respectively.…”

Section: Methodsmentioning

confidence: 99%

Inhibitory effect of DS-4574, a peptidoleukotriene antagonist with mast cell stabilizing action, on compound 48/80-induced gastric mucosal lesions in rats

Tabuchi¹,

Kawarabayashi²,

Furuhama³

1994

Agents and Actions

View full text Add to dashboard Cite

show abstract

“…The compound, even at the dose of 32 mg/kg, also did not significantly affect the occurrence, either the incidence or the time of onset of VT or VF, nor did it influence the changes in blood pressure and heart rate following left coronary artery ligation. This is unlikely to be due to inadequate dosage of the drug used because disodium cromoglycate 5 mg/kg has been shown to be sufficient to prevent reserpine-induced mast cell degranulation in the rat gastric mucosa [23]. Therefore, results of this observation suggest that it is the cardiac histamine of non-mast cell stores, but not that of mast cell stores, which may be involved in the causation of cardiovascular changes during acute myocardial ischaemia, if histamine does play a role [5][6][7][8][9][10].…”

Section: Discussionmentioning

confidence: 96%

Ventricular histamine concentrations and mast cell counts in the rat heart during acute ischaemia

Dai

Ogle

1990

Agents and Actions

View full text Add to dashboard Cite

The ventricular histamine concentrations and mast cell counts of naive and disodium cromoglycate-treated rats subjected to acute left coronary artery ligation under pentobarbitone anaesthesia were examined. In naive animals, there was a significant increase in the right ventricular histamine level at 2 min following left coronary artery ligation. Left ventricular histamine concentrations tended to decrease, and were significantly lower than those of the right ventricle at 5 min. However there were no significant changes in mast cell counts of the right or left ventricles after left coronary artery ligation. Treatment with disodium cromoglycate did not significantly alter the ventricular mast cell counts, interfere with the changes in ventricular histamine concentrations, or the occurrence of early ventricular arrhythmias and haemodynamic changes in response to acute left coronary artery ligation. It is suggested that the increase in the right and decrease in the left ventricular histamine concentrations during acute myocardial ischaemia involves mainly the non-mast cell stores, instead of mast cell sources, of cardiac histamine.

show abstract

“…Another effect of mast cell stabilisers on gastric mucosa has been shown in rats where intraperitoneal reserpine normally produces gastric ulceration, but treatment with disodium cromoglycate during the preceding 4 days reduces this damage (Ogle & Lau, 1979). The authors suggest that this effect may be related directly to inhibition of changes in the microcirculation which follows administration of reserpine; these changes are thought to be mediated by mast cell degranulation and may be reduced because of the mast cell stabilising property of the drug.…”

Section: Initial Pentagastrin Testmentioning

confidence: 99%

Inhibition of gastric acid secretion with a mast cell stabiliser, FPL− 52694.

Davies¹,

Rhodes²,

Thomas³

1981

Brit J Clinical Pharma

View full text Add to dashboard Cite

Loughborough1 The effect on gastric acid secretion of a mast cell stabiliser FPL-52694 was examined in nine healthy volunteers. 2 The compound which is moderately well absorbed after oral ingestion, was taken for 5 days prior to the measurement of acid secretion and was also given intravenously during part of the gastric test. A submaximal dose of pentagastrin (0.3 ,g/kg/h) was given by intravenous infusion for 2 h in a controlled test and then after administration of FPL-52694. 3 There was a significant reduction (37%) in acid secretion during the second test which was probably due to the effect of the compound on mast cell degranulation in the gastric mucosa.

show abstract

Disodium cromoglycate: a novel gastric antiulcer agent?

Cited by 28 publications

References 9 publications

Inhibitory effect of DS-4574, a peptidoleukotriene antagonist with mast cell stabilizing action, on compound 48/80-induced gastric mucosal lesions in rats

Inhibitory effect of DS-4574, a peptidoleukotriene antagonist with mast cell stabilizing action, on compound 48/80-induced gastric mucosal lesions in rats

Ventricular histamine concentrations and mast cell counts in the rat heart during acute ischaemia

Inhibition of gastric acid secretion with a mast cell stabiliser, FPL− 52694.

Contact Info

Product

Resources

About