Dislocations and the Femoral Head Size in Primary Total Hip Arthroplasty

Hedlundh, Urban; Ahnfelt, Lennart; Ch, Hybbinette; Wallinder, Lars; Weckström, J; Fredin, Hans

doi:10.1097/00003086-199612000-00024

Cited by 90 publications

(48 citation statements)

References 15 publications

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“…BMPs play important roles in the osteogenic process -namely, the promotion of cell chemotaxis, mitosis, and cell differentiation (Hedlundh et al, 1996;Kelley et al, 1998;Bartz et al, 2000;Mahoney and Pellicci, 2003). The complicated process of BMSC differentiation into mature osteogenic cells occurs through the interactions of many system, paracrine, and autocrine factors.…”

Section: Discussionmentioning

confidence: 99%

Recombinant adeno-associated virus BMP-4/7 fusion gene confers ossification activity in rabbit bone marrow stromal cells

Cb²,

Cu³

et al. 2012

Genet. Mol. Res.

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ABSTRACT. The biological effects of transfection of an adeno-associated virus (AAV) vector with bone morphogenetic proteins 4 and 7 (BMP-4/7) fusion gene (AAV-BMP-4/7) were determined in rabbit bone marrow stromal cells (BMSCs). BMP-4 and BMP-7 genes were obtained through one-step reverse transcriptase polymerase chain reaction from human placental cells. The BMP-4/7 fusion gene was then generated through recombination. Rabbit BMSCs were transfected with the recombinant AAV vectors carrying AAV-BMP-4/7 with multiplicity of infection values. Cell growth curves were drawn to evaluate the biological effects of AAV-BMP-4/7 on cell activity. The transfection efficiency was measured using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. The ossification of cells was evaluated by observing alkaline phosphatase (ALP) and osteocalcin (OC) activity after transfection for 7 and 14 days. The cells were then transfected with AAV-BMP-4/7 and AAV-enhanced green fluorescent protein. We successfully constructed the recombinant adeno-associated virus with the BMP-4/7 fusion gene. The transfection efficiency of AAV-BMP-4/7 was approximately 72% without significant biological effects on cell activity. Cell ossification was significant after 5 vg/cell multiplicity of infection value of transfection efficiency was more than 5 x 10 4 vg/cell (59.38%). Significantly higher ALP and OC activity occurred in the AAV-BMP-4/7 transfection groups than in the AAV-enhanced green fluorescent protein groups (t ALP = 896.88, P < 0.001; t OC = 543.24, P < 0.01). The AAV-BMP-4/7 fusion gene can highly efficient transfect rabbit BMSCs cultured in vitro and it has significant ossification activity.

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Section: Discussionmentioning

confidence: 99%

Recombinant adeno-associated virus BMP-4/7 fusion gene confers ossification activity in rabbit bone marrow stromal cells

Cb²,

Cu³

et al. 2012

Genet. Mol. Res.

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“…In addition, the revision burden is expected to increase over the next 20 years from 10% presently to over 20% of all THAs by the year 2030 [25]. Dislocation causes are multifactorial and are associated with femoral stem design [1,48], acetabular component orientation [2,7,28], surgical approach [7,31,34], soft tissue laxity [40], femoral head size [12,21,23,34], and other patient-specific factors [7,18,34].…”

Section: Introductionmentioning

confidence: 99%

What Factors Affect Posterior Dislocation Distance in THA?

Nevelos

Johnson

Heffernan

et al. 2013

Clinical Orthopaedics &Amp; Related Research

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Background Dislocation remains common after total hip arthroplasty. Efforts have been made to identify and minimize risk factors. One such factor, jump distance, or the distance the femoral head must travel before dislocating, has been poorly characterized with respect to threedimensional kinematics.Questions/purposes We therefore determined: (1) the three-dimensional stability of four different component designs; (2) whether the degree of abduction and anteversion affects the stability; (3) whether pelvic inclination angles affected stability; and (4) which combination of these three factors had the greatest stability. Methods We created a positionable three-dimensional model of a THA. Acetabular components were modeled in various abduction and anteversion angles and in two different pelvic inclinations which simulate standing and chair-rising activities.

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“…Clinical series of primary hip arthroplasty report incidences from 0.6% to 3% [9,18,26,44,46], with even higher dislocation rates in certain subsets of primary patients (such as obesity and hip dysplasia) and after revision surgery [4,7,13,16,17,20,25,27,32]. ROM before impingement is an important indicator of joint stability, and surgeons often use it as an intraoperative test to assess hip stability [3,22,33,36,37].…”

Section: Introductionmentioning

confidence: 99%

Bony Impingement Limits Design-related Increases in Hip Range of Motion

Bunn

Colwell

D’Lima

2012

Clinical Orthopaedics &Amp; Related Research

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Background Factors affecting risk for impingement and dislocation can be related to the patient, implant design, or surgeon. While these have been studied independently, the impact of each factor relative to the others is not known. Questions/purposes We determined the effect of three implant design factors, prosthetic placement, and patient anatomy on subject-specific ROM. Methods We virtually implanted hip geometry obtained from 16 CT scans using computer models of hip components with differences in head size, neck diameter, and neck-shaft angle. A contact detection model computed ROM before prosthetic or bony impingement. We correlated anatomic measurements from pelvic radiographs with ROM.

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Dislocations and the Femoral Head Size in Primary Total Hip Arthroplasty

Cited by 90 publications

References 15 publications

Recombinant adeno-associated virus BMP-4/7 fusion gene confers ossification activity in rabbit bone marrow stromal cells

Recombinant adeno-associated virus BMP-4/7 fusion gene confers ossification activity in rabbit bone marrow stromal cells

What Factors Affect Posterior Dislocation Distance in THA?

Bony Impingement Limits Design-related Increases in Hip Range of Motion

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