Diskontinuierliche topische Corticoidtherapie

Pflugshaupt, Ch.

doi:10.1007/978-3-642-69831-6_11

Cited by 2 publications

(2 citation statements)

References 83 publications

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“…For example, discontinuous administra tion of the topical glucocorticoid is performed [1). Such a treatment regimen not only reduces the risk of side effects but also the costs.…”

Section: Introductionmentioning

confidence: 99%

Steroid-Induced Dermal Thinning: Discontinuous Application of Clobetasol-17-Propionate Ointment

Lubach

Rath²,

Kietzmann

1992

Dermatology

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The skin thinning effect of discontinuous topical clobetasol-17-propionate applications was tested in human volunteers. Application frequencies were daily (1/0), every third day (1/2), every fifth day (1/4), every seventh day (1/6) and every ninth day (1/8). Clobetasol-17-propionate was administered topically under occlusion for 1 h. The treatment period was 41 days. There were no differences of the skin thinning effect of daily and 1/2 administration. The skin thinning effect of 1/4, 1/6 and 1/8 was smaller but also significant compared to controls. The curves demonstrating skin thinning effects initially were dropping off and reached a plateau within about 2 weeks. After finishing application, skin thickness normalized within 2 weeks. Because of these findings, a treatment intervall of 3 days is discussed as therapeutically efficient.

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“…For example, discontinuous administra tion of the topical glucocorticoid is performed [1). Such a treatment regimen not only reduces the risk of side effects but also the costs.…”

Section: Introductionmentioning

confidence: 99%

Steroid-Induced Dermal Thinning: Discontinuous Application of Clobetasol-17-Propionate Ointment

Lubach

Rath²,

Kietzmann

1992

Dermatology

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“…There is also a range of therapeutic local treatment for eczemas. A wealth of strategies for topical glucocorticosteroids: once or twice-daily application either continuously, discontinuously, or graduated therapy up to on/off-therapy [2,3]. So far there exists no binding therapeutic regimen for * Tel.…”

Section: Introductionmentioning

confidence: 99%

Clinical comparison of methylprednisolone aceponate and prednicarbate in chronic eczema

Albrecht¹

1994

Acad Dermatol Venereol

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Methylprednisolone aceponate (MPA) is a new topical corticosteroid developed specifically for the treatment of eczematous disorders. A multicentre, controlled, randomized open trial to assess the efficacy and tolerability of a once daily application of MPA in comparison to a twice-daily application of Prednicarbate (PC) was conducted in 566 patients suffering from allergic contact eczema (51.2%), toxic degenerative eczema (46.8%) as well as a combination of allergic contact eczema and toxic degenerative eczema (1.9%). Both treatment groups were approximately the same size, 280 patients being treated with MPA, 286 with PC.Treatment was carried out for a maximum of 28 days. The median duration of treatment was 22 days with MPA and 21 days with PC. Clinical efficacy was not different between MPA ointment (0.1%) used once daily with 45.5% complete healing and 39.8% marked improvement as compared to PC ointment (0.25%) used twice daily with 48.3% complete healing and 40.2% marked improvement. Both treatments were well tolerated. 4.6% of the patients reported adverse events on MPA-treatment and 3.8% on PC-treatment. No serious events were experienced. From this study it can be concluded that in various eczematous disorders efficacy and tolerability of MPA ointment used once daily are essentially the same as for PC ointment used twice daily.

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Diskontinuierliche topische Corticoidtherapie

Cited by 2 publications

References 83 publications

Steroid-Induced Dermal Thinning: Discontinuous Application of Clobetasol-17-Propionate Ointment

Steroid-Induced Dermal Thinning: Discontinuous Application of Clobetasol-17-Propionate Ointment

Clinical comparison of methylprednisolone aceponate and prednicarbate in chronic eczema

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