Disintegration-controllable stimuli-responsive polyelectrolyte multilayer microcapsules via covalent layer-by-layer assembly

Graphene Oxide (GO)-based Nanosheets With Combined Chemo/photothermal/Photodynamic Therapy to Overcome Gastric Cancer (GC) Paclitaxel Resistance by Reducing Mitochondria-Derived Adenosine-Triphosphate (ATP)

“…Alginate is a naturally existing polysaccharide, exhibiting excellent biodegradability, biocompatibility, and water solubility [29]. Oxidized sodium alginate (OSA)-based biomaterials have pH-responsive property now that the presence of aldehyde groups, and its hydrophilic property could help avoid drug clearance by the mononuclear phagocyte system post-intravenous injection [18,19]. Consequently, the functionalization of OSA onto GO-PEG might facilitate pH-sensitive drug release effect.…”

“…Meanwhile, pH-responsive smart drug delivery could help release PTX toward the nucleus and then induce more cancer cells death [16]. Oxidized sodium alginate (OSA) is a naturally existent polysaccharide which possesses pH-responsive properties due to the presence of aldehyde groups, and its hydrophilic property could help to avoid drug clearance by the mononuclear phagocyte system post intravenous injection [17][18][19]. Hence, we assumed that the functionalization of OSA onto GO-PEG might induce a pH-sensitive drug release effect, while GO-PEG-OSA nano-DDSs for pH-triggered releasing PTX are yet seldomly reported.…”

Chitosan/Alginate Dialdehyde Multilayer Films with Modulated pH‐Responsiveness and Swelling

“…swelling and pH-responsivity rather than prompt disintegration. [13,14] To address this issue, one can postcross-link the multilayer film to inhibit the excessive swelling and disintegration. [15,16] This approach, in general, has several shortcomings though: i) the common cross-linkers, e.g., glutaraldehyde, are mostly toxic, ii) the introduced cross-linker could modify the physicochemical properties of the film, iii) additional postcrosslinking and rinsing steps are required, iv) diffusion barrier could cause inhomogeneous cross-linking within the film, and v) controlling the cross-linking density is challenging since it requires changing the concentration of cross-linker, crosslinking time, or cross-linker type.…”

“…[ 11,12 ] Nevertheless, some applications, e.g., oral delivery to the gastrointestinal tract, require a more stable multilayer film with moderate swelling and pH‐responsivity rather than prompt disintegration. [ 13,14 ]…”

Swelling Behavior, Interaction, and Electrostatic Properties of Chitosan/Alginate Dialdehyde Multilayer Films with Different Outermost Layer

“…16 For this reason, CHI/ADA multilayer films are considered as promising coating materials for biomedical applications such as targeted drug delivery and tissue engineering. [17][18][19][20][21][22][23][24] Regarding the structure, a polyelectrolyte multilayer film is generally divided into two distinct regions. 25,26 The internal part of the film consists of complexes of oppositely charged polyions, which comprise interpenetrated polymer chains with approximately 1:1 charge stoichiometry (intrinsic charge compensation).…”