Disintegrating Agents in Hard Gelatin Capsules. Part II: Swelling Efficiency

Understanding Disintegrant Action by Visualization

“…The markedly less swelling of XPVP particles could be attributed to the absence of free hydroxyl group and lower water binding capacity of XPVP polymer in comparison with cellulose 44. It was also reported that compacts containing XPVP absorbed liquid (0.1 N HCl) at a much slower rate than starch‐based materials in the initial stages of wetting 45. The findings suggested that XPVP did not show high capillary action (high initial liquid absorption rate).…”

Quantification of swelling characteristics of pharmaceutical particles

“…When comparing the results of single particles to the swelling behaviour of a powder compact, the exact formulation and microstructure of a tablet needs to be considered. measured how the disintegration time of dibasic calcium phosphate tablet is affected by the used disintegrant and Botzolakisi and Augsburger (1988) measured the swelling and liquid uptake rate of pure disintegrant compacts. Both indicated that the use of CCS results in faster tablet disintegration compared to a SSG tablet.…”

“…The authors described the swelling mecha-nism of XPVP as strain recovery (swelling in axial direction). Botzolakisi and Augsburger (1988) quantified the swelling and liquid uptake rate of pure disintegrant tablets revealing that CCS tablets exhibited the greatest swelling and highest liquid uptake rate followed by SSG. Several studies quantified the disintegrant swelling of powder compacts Rojas et al (2012); Desai et al (2012); Berardi et al (2018); Botzolakisi and Augsburger (1988) and suspensions (Zhao and Augsburger, 2005).…”

Bioresorbable Materials and Their Application in Electronics

“…Parameters such as molecular weight and isoelectric point can be changed depending on the processing conditions. In vivo dissolution and degradation of gelatin are more rapid than for silk, because gelatin can readily swell and dissolve in water [238][239][240] . The process can be facilitated by escalated pH levels [241] and enzymatic degradation [242,243] .…”