volume 110, issue 5, P2028-2037 2021
DOI: 10.1016/j.xphs.2020.11.002
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Abstract: The hydrophobicity of poorly soluble drugs can delay tablets disintegration. We probed here the influence of different disintegrants on the disintegration of challenging hydrophobic formulations. Tablets containing diluents, hydrogenated vegetable oil and either sodium starch glycolate (SSG), croscarmellose sodium (CCS) or crospovidone (XPVP) were prepared. The disintegration time of tablets was tested immediately and after storage at 40 C and 75% RH in sealed bags. Results show that storage and compression fo…

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