Disinhibitory shift of recovery curve of somatosensory-evoked response in elderly: A magnetoencephalographic study

Goto, Sachiko; Fujisawa, Yukiko; Uemura, Junichi; Yamada, Sumio; Hoshiyama, Minoru; Hirayama, Masaaki

doi:10.1016/j.clinph.2014.09.018

Cited by 10 publications

(9 citation statements)

References 21 publications

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“…Furthermore, the Lenz study used peak-to-peak differences (N20 to P25) to compute gating ratios, and a very short inter-stimulation interval of 30 ms, both of which are very different than the current study and those of Cheng and Lin (2013)and Cheng, Chan, Baillet et al (2015). Finally, there is also data suggesting that age-related gating effects in the time-domain are only present when the interstimulation interval is less than 200 ms (Goto et al 2015), which could explain our findings and those of Cheng, Chan, Baillet et al 2015. Unfortunately, no studies to date have evaluated gamma range activity in the context of gating and aging, and thus we cannot comment on whether the inter-stimulation interval affects such gating responses.…”

Section: Discussionmentioning

confidence: 58%

“…For example, studies using electrical paired-pulse stimulation paradigms have shown robust sensory gating following median nerve stimulation in healthy adults (Hsiao et al 2013;Cheng, Chan, Niddam et al 2016), as well as reduced sensory gating in healthy older relative to younger adults using the same paradigm (Lenz et al 2012;Cheng and Lin 2013). Likewise, another healthy aging study found that older adults had reduced gating relative to younger adults when the paired electrical pulses were temporally separated by 100 ms or less, but that the 2 groups gated roughly equally when the pulses were 200 ms apart (Goto et al 2015). These data may suggest that older adults have altered inhibitory function, which leads to aberrant gating when stimuli are presented in rapid succession and normal gating at longer temporal intervals.…”

Section: Introductionmentioning

confidence: 97%

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Rhythmic Spontaneous Activity Mediates the Age-Related Decline in Somatosensory Function

et al. 2018

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Sensory gating is a neurophysiological process whereby the response to a second stimulus in a pair of identical stimuli is attenuated, and it is thought to reflect the capacity of the CNS to preserve neural resources for behaviorally relevant stimuli. Such gating is observed across multiple sensory modalities and is modulated by age, but the mechanisms involved are not understood. In this study, we examined somatosensory gating in 68 healthy adults using magnetoencephalography (MEG) and advanced oscillatory and time-domain analysis methods. MEG data underwent source reconstruction and peak voxel time series data were extracted to evaluate the dynamics of somatosensory gating, and the impact of spontaneous neural activity immediately preceding the stimulation. We found that gating declined with increasing age and that older adults had significantly reduced gating relative to younger adults, suggesting impaired local inhibitory function. Most importantly, older adults had significantly elevated spontaneous activity preceding the stimulation, and this effect fully mediated the impact of aging on sensory gating. In conclusion, gating in the somatosensory system declines with advancing age and this effect is directly tied to increased spontaneous neural activity in the primary somatosensory cortices, which is likely secondary to age-related declines in local GABA inhibitory function.

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Section: Discussionmentioning

confidence: 58%

Section: Introductionmentioning

confidence: 97%

Rhythmic Spontaneous Activity Mediates the Age-Related Decline in Somatosensory Function

et al. 2018

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“…139,144-145 Interestingly, similar age-related differences have been reported in somatosensory MEG studies utilizing median nerve stimulation, with older adults exhibiting an increased early cortical response in the primary somatosensory cortices, 146-151 especially contralateral to the stimulated nerve. 146-150 Of note, neural responses at later latencies are typically more comparable in strength and do not generally show aging effects in auditory or somatosensory modalities, although there have been exceptions. 138,141 Together these studies suggest that early hyper-responsivity to sensory stimulation in the elderly may underlie age-related behavioral deficits in sensory processing.…”

Section: Healthy Agingmentioning

confidence: 99%

Neuroimaging with magnetoencephalography: A dynamic view of brain pathophysiology

Wilson

Heinrichs‐Graham

Proskovec

et al. 2016

Translational Research

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Magnetoencephalography (MEG) is a noninvasive, silent, and totally-passive neurophysiological imaging method with excellent temporal resolution (∼1 ms) and good spatial precision (∼3-5 mm). In a typical experiment, MEG data are acquired while healthy controls and/or patients with neurologic or psychiatric disorders perform a specific cognitive task and/or receive sensory stimulation. The resulting data are generally analyzed using standard electrophysiological methods, coupled with advanced image reconstruction algorithms. To date, the total number of MEG instruments and associated users is significantly smaller than comparable human neuroimaging techniques, although this is likely to change in the near future with advances in the technology. Despite this small base, MEG research has made a significant impact on several areas of translational neuroscience, largely through its unique capacity to quantify the oscillatory dynamics of activated brain circuits in humans. This review focuses on the clinical areas where MEG imaging has arguably had the greatest impact, in regard to the identification of aberrant neural dynamics at the regional and/or network-level, monitoring of disease progression, determining how efficacious pharmacological and behavioral interventions modulate neural systems, and the development of neural markers of disease. Specifically, this review covers recent advances in understanding the abnormal neural oscillatory dynamics that underlie Parkinson's disease, autism spectrum disorders, HIV-associated neurocognitive disorders, cerebral palsy, attention-deficit/hyperactivity disorder, cognitive aging, and posttraumatic stress disorder. MEG imaging has had a major impact on how clinical neuroscientists understand the brain basis of these disorders, and its translational influence is rapidly expanding with new discoveries and applications emerging continuously.

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“…In human studies, drug-related PPD changes have shown that GABA is related to PPD (Huttunen et al 2008 ; Stude et al 2016 ). Moreover, PPD is reduced in elderly people (Goto et al 2015 ; Lenz et al 2012 ), and GABA concentrations decrease with age (Grachev et al 2001 ). In addition, PPD induced by somatosensory stimulation is related to the degradation of tactile perception (Lenz et al 2012 ; Rocchi et al 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Variability and Reliability of Paired-Pulse Depression and Cortical Oscillation Induced by Median Nerve Stimulation

et al. 2018

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Paired-pulse depression (PPD) has been widely used to investigate the functional profiles of somatosensory cortical inhibition. However, PPD induced by somatosensory stimulation is variable, and the reasons for between- and within-subject PPD variability remains unclear. Therefore, the purpose of this study was to clarify the factors influencing PPD variability induced by somatosensory stimulation. The study participants were 19 healthy volunteers. First, we investigated the relationship between the PPD ratio of each component (N20m, P35m, and P60m) of the somatosensory magnetic field, and the alpha, beta, and gamma band changes in power [event-related desynchronization (ERD) and event-related synchronization (ERS)] induced by median nerve stimulation. Second, because brain-derived neurotrophic factor (BDNF) gene polymorphisms reportedly influence the PPD ratio, we assessed whether BDNF genotype influences PPD ratio variability. Finally, we evaluated the test–retest reliability of PPD and the alpha, beta, and gamma ERD/ERS induced by somatosensory stimulation. Significant positive correlations were observed between the P60m_PPD ratio and beta power change, and the P60m_PPD ratio was significantly smaller for the beta ERD group than for the beta ERS group. P35m_PPD was found to be robust and highly reproducible; however, P60m_PPD reproducibility was poor. In addition, the ICC values for alpha, beta, and gamma ERD/ERS were 0.680, 0.760, and 0.552 respectively. These results suggest that the variability of PPD for the P60m deflection may be influenced by the ERD/ERS magnitude, which is induced by median nerve stimulation.Electronic supplementary materialThe online version of this article (10.1007/s10548-018-0648-5) contains supplementary material, which is available to authorized users.

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Disinhibitory shift of recovery curve of somatosensory-evoked response in elderly: A magnetoencephalographic study

Cited by 10 publications

References 21 publications

Rhythmic Spontaneous Activity Mediates the Age-Related Decline in Somatosensory Function

Rhythmic Spontaneous Activity Mediates the Age-Related Decline in Somatosensory Function

Neuroimaging with magnetoencephalography: A dynamic view of brain pathophysiology

Variability and Reliability of Paired-Pulse Depression and Cortical Oscillation Induced by Median Nerve Stimulation

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