Disinfection Processes

Munakata, Naoko; Kuo, Jeff

doi:10.2175/106143016x14696400494696

Cited by 3 publications

(1 citation statement)

References 101 publications

(102 reference statements)

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“…Some commonly used disinfection methods include using ethanol, chlorine, formaldehyde, and hydrogen peroxide at different concentrations [2][3][4]. However, disinfection using chemical agents is only sometimes as effective against different pathogens as it requires active management [4].…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Activity of Filtered Far‐UVC Light (222 nm) against Different Pathogens

Lorenzo-Leal,

Tam,

Kheyrandish

et al. 2023

BioMed Research International

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Ultraviolet (UV) light is an effective disinfection technology, able to inactivate a wide range of microorganisms, including bacteria and fungi. A safer UV wavelength of 222 nm, also known as far-UVC, has been proposed to minimize these harmful effects while retaining the light’s disinfection capability. This study is aimed at exploring the antimicrobial activity of filtered far-UVC (222 nm) on a panel of pathogens commonly found in nosocomial installations. A panel of Gram-positive and Gram-negative bacteria and yeast pathogens was tested. Microorganisms were deposited on a plastic surface, allowing them to dry before exposure to the far-UVC light at a distance of 50 cm. Results showed that far-UVC light successfully inhibits the growth of the tested pathogens, although at different exposure times. In conclusion, the results of this study provide fundamental information to achieve reliable disinfection performance with far-UVC lamps with potential applications in healthcare facilities like hospitals and long-term care homes.

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Section: Introductionmentioning

confidence: 99%

Antimicrobial Activity of Filtered Far‐UVC Light (222 nm) against Different Pathogens

Lorenzo-Leal,

Tam,

Kheyrandish

et al. 2023

BioMed Research International

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The absence or presence of a lytic coliphage affects the response of Escherichia coli to heat, chlorine, or UV exposure

et al. 2018

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Disinfection aims at maximal inactivation of target organisms and the sustainable suppression of their regrowth. Whereas many disinfection efforts achieve efficient inactivation when the effect is measured directly after treatment, there are questions about the sustainability of this effect. One aspect is that the treated bacteria might recover and regain the ability to grow. In an environmental context, another question is how amenable surviving bacteria are to predation by omnipresent bacteriophages. Provisional data suggested that bacteria when subjected to sublethal heat stress might develop a phage-resistant phenotype. The result made us wonder about the susceptibility to phage-mediated lysis for bacteria exposed to a gradient of chlorine and UV-LED disinfection strengths. Whereas bacteria exposed to low sublethal chlorine doses still underwent phage-mediated lysis, the critical chlorine Ct of 0.5 mg min/L eliminated this susceptibility and induced phage resistance in the cells that survived treatment. In the case of UV, even the smallest tested dose of 2.8 mJ/cm abolished phage lysis leading to direct regrowth. Results suggest that bacteria surviving disinfection might have higher environmental survival chances directly after treatment compared to non-treated cells. A reason could possibly lie in their compromised metabolism that is essential for phage replication.

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Antimicrobial Effect Of Visible Blue Light Used In A Minimally Invasive Intramedullary Fracture Stabilization System

Oijen

Croughs

Hagenaars

et al. 2019

J. Bone Joint Infect.

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Introduction: Since 2009, the IlluminOss® System is being used as an intramedullary fracture treatment. The system is characterized by the use of blue light to polymerize liquid monomer after its infusion in a polyethylene terephthalate balloon. Very few infections of the material have been observed, which might be explained by the possible antimicrobial side-effect of the blue light used in this intramedullary fracture stabilization system. This study aimed to assess this antimicrobial (side-)effect on S. aureus.Methods: A suspension of 1.5 x 103 CFU/ml of 8325-4 S. aureus was placed into five, custom made, black delrin cylinders. The implant was placed into the cylinders and the light source was activated for 200, 400, 600, 800, or 1,000 seconds. 100 µL of the light exposed suspension was grafted on blood agar and placed in a 35 degrees Celsius incubator for 24 hours. Colonies on each agar plate were counted and compared to the control plates (no blue light exposure).Results: The control plates showed a mean of 85 ± 15 colonies per plate. A statistically significant decrease was observed after 600 seconds of exposure time; mean colony count of 63 ± 4 (p <0.05). The absolute reduction was 24 ± 14 after 600 seconds exposure time. At 800 and 1,000 seconds, no statistically significant reduction was found compared with the control plates (means 72 ± 10 and 83 ± 14 colonies, respectively).Conclusions: In this study only a temporary reduction of S. aureus was observed.If future research regarding the antimicrobial characteristics of blue light used in the IlluminOss® System is desired, it should focus on the need for oxygen and its availability and the dose and manner of applying the light.

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Disinfection Processes

Abstract: A review of the literature published in 2015 on topics relating to disinfection processes is presented. This review is divided into the following sections: disinfection methods, disinfection byproducts, and microbiology and microbial communities.

Cited by 3 publications

References 101 publications

Antimicrobial Activity of Filtered Far‐UVC Light (222 nm) against Different Pathogens

Antimicrobial Activity of Filtered Far‐UVC Light (222 nm) against Different Pathogens

The absence or presence of a lytic coliphage affects the response of Escherichia coli to heat, chlorine, or UV exposure

Antimicrobial Effect Of Visible Blue Light Used In A Minimally Invasive Intramedullary Fracture Stabilization System

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