Disinfection performance of chlorine dioxide gas at ultra-low concentrations and the decay rules under different environmental factors

Ning, Pei-Yong; Shan, Dan; Hong, Enlv; Liu, Lumin; Zhu, Yun; Cui, Runmeng; Zhou, Y.; Wang, Baiqi

doi:10.1080/10962247.2020.1769768

Cited by 4 publications

(3 citation statements)

References 29 publications

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“…Chlorine dioxide solution (CDS) is a potent oxidant and a prodrug of HOCl that is widely used as a biocide. (1) CDS has cytotoxic effects on cancer cells. (2) The cytotoxicity of CDS on cancer cells appears to be associated with the induction of oxidation that disrupts the delicate and controlled redox balance of cancer cells, which induces apoptosis, pyknosis, and necrosis.…”

Section: Introductionmentioning

confidence: 99%

Case Report: Compassionate application of chlorine dioxide-based solution in a patient with metastatic prostate cancer

Aparicio-Alonso,

Torres-Solórzano

2024

Salud, Ciencia y Tecnología

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Chlorine dioxide is a powerful and cost-effective oxidizing agent that has demonstrated anti-cancer activity both in vitro and in vivo. Its proposed mechanism involves the release of free radicals, which disrupt the delicate oxidative balance within cancer cells. In case report, the patient has voluntarily opted for compassionate chlorine dioxide therapy over continuing conventional chemotherapy and immunotherapy due to side effects and uncertain survival outcomes. The concentration of the chlorine dioxide solution was 1/100 times lower than the LOAEL threshold, ensuring that not compromise the patients' health. This is the first follow-up in patient diagnosed with metastatic prostate cancer, who shown tumor reduction at distant sites from the primary tumor with no side effects. This preliminary observation suggests that chlorine dioxide and its free radicals could be potential mediators of an anticancer response. However, it is imperative to emphasize the importance of conducting rigorous clinical trials to validate these initial findings.

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Section: Introductionmentioning

confidence: 99%

Case Report: Compassionate application of chlorine dioxide-based solution in a patient with metastatic prostate cancer

Aparicio-Alonso,

Torres-Solórzano

2024

Salud, Ciencia y Tecnología

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“…Chemical factors that can be distinguished in a wide range of disinfectants are peracetic acid (PAA), hydrogen peroxide (H 2 O 2 ) and chlorine [ 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 ]. Otterspoor and Farrell have proven the advantage of using peracetic acid-based disinfectants.…”

Section: Introductionmentioning

confidence: 99%

Is Peracetic Acid Fumigation Effective in Public Transportation?

Kruszewska

Czupryna

Pancewicz

et al. 2022

IJERPH

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The COVID-19 pandemic made more people aware of the danger of viruses and bacteria, which is why disinfection began to be used more and more often. Epidemiological safety must be ensured not only in gathering places, but also in home and work environments. It is especially challenging in public transportation, which is a perfect environment for the spread of infectious disease. Therefore, the aim of the study was the identification of bacteria in crowded places and the evaluation of the effect of fumigation with peracetic acid (PAA) in public transportation. Inactivation of microorganisms in buses and long-distance coaches was carried out using an automatic commercial fogging device filled with a solution of peracetic acid stabilized with acetic acid (AA) and hydrogen peroxide (H2O2). Before and after disinfection, samples were taken for microbiological tests. The most prevalent bacteria were Micrococcus luteus and Bacillus licheniformis.Staphylococcus epidermidis was only present in buses, whereas Staphylococcus hominis and Exiguobacterium acetylicum were only present in coaches. Statistical analysis showed a significant reduction in the number of microorganisms in samples taken from different surfaces after disinfection in vehicles. The overall effectiveness of disinfection was 81.7% in buses and 66.5% in coaches. Dry fog fumigation with peracetic acid is an effective method of disinfecting public transport vehicles.

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“…Since the beginning of the pandemic, new technologies and protocols have been developed with the purpose of exercising microbial control efficiently, thereby targeting a reduction in the infection rate [ 36 , 37 ]. Here, we discuss technologies that have been adopted to help combat contamination by SARS-CoV-2.…”

Section: Introductionmentioning

confidence: 99%

Numerical and experimental analyses for the improvement of surface instant decontamination technology through biocidal agent dispersion: Potential of application during pandemic

et al. 2021

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The transmission of SARS-CoV-2 through contact with contaminated surfaces or objects is an important form of transmissibility. Thus, in this study, we evaluated the performance of a disinfection chamber designed for instantaneous dispersion of the biocidal agent solution, in order to characterize a new device that can be used to protect individuals by reducing the transmissibility of the disease through contaminated surfaces. We proposed the necessary adjustments in the configuration to improve the dispersion on surfaces and the effectiveness of the developed equipment. Computational Fluid Dynamics (CFD) simulations of the present technology with a chamber having six nebulizer nozzles were performed and validated through qualitative and quantitative comparisons, and experimental tests were conducted using the method Water-Sensitive Paper (WSP), with an exposure to the biocidal agent for 10 and 30 s. After evaluation, a new passage procedure for the chamber with six nozzles and a new configuration of the disinfection chamber were proposed. In the chamber with six nozzles, a deficiency was identified in its central region, where the suspended droplet concentration was close to zero. However, with the new passage procedure, there was a significant increase in wettability of the surface. With the proposition of the chamber with 12 nozzles, the suspended droplet concentration in different regions increased, with an average increase of 266%. The experimental results of the new configuration proved that there was an increase in wettability at all times of exposure, and it was more significant for an exposure of 30 s. Additionally, even in different passage procedures, there were no significant differences in the results for an exposure of 10 s, thereby showing the effectiveness of the new configuration or improved spraying and wettability by the biocidal agent, as well as in minimizing the impact caused by human factor in the performance of the disinfection technology.

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Disinfection performance of chlorine dioxide gas at ultra-low concentrations and the decay rules under different environmental factors

Cited by 4 publications

References 29 publications

Case Report: Compassionate application of chlorine dioxide-based solution in a patient with metastatic prostate cancer

Case Report: Compassionate application of chlorine dioxide-based solution in a patient with metastatic prostate cancer

Is Peracetic Acid Fumigation Effective in Public Transportation?

Numerical and experimental analyses for the improvement of surface instant decontamination technology through biocidal agent dispersion: Potential of application during pandemic

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