Disinfection of cell-associated and extracellular HIV-1 by PUVA treatment

Deichmann, Martin; Sczakiel, Georg; Haas, Rainer

doi:10.1016/s0166-0934(97)00112-2

Cited by 3 publications

(2 citation statements)

References 8 publications

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“…types, including some CD34+CD38 cells 1 1 " (11,12). In vitro SDF-1 attracts certain CD34+CXCR4+ cells, and i n vivo it is produced by bone marrow stromal cells as well as by epithelial cells i n many organs (11,13,14).…”

Section: ~~[~D~r Mmentioning

confidence: 99%

Dependence of Human Stem Cell Engraftment and Repopulation of NOD/SCID Mice on CXCR4

Peled¹,

Petit²,

Kollet³

et al. 1999

Science

1,561

1,264

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Stem cell homing and repopulation are not well understood. The chemokine stromal cell-derived factor-1 (SDF-1) and its receptor CXCR4 were found to be critical for murine bone marrow engraftment by human severe combined immunodeficient (SCID) repopulating stem cells. Treatment of human cells with antibodies to CXCR4 prevented engraftment. In vitro CXCR4-dependent migration to SDF-1 of CD34+CD38-/low cells correlated with in vivo engraftment and stem cell function. Stem cell factor and interleukin-6 induced CXCR4 expression on CD34+ cells, which potentiated migration to SDF-1 and engraftment in primary and secondary transplanted mice. Thus, up-regulation of CXCR4 expression may be useful for improving engraftment of repopulating stem cells in clinical transplantation.

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Section: ~~[~D~r Mmentioning

confidence: 99%

Dependence of Human Stem Cell Engraftment and Repopulation of NOD/SCID Mice on CXCR4

Peled¹,

Petit²,

Kollet³

et al. 1999

Science

1,561

1,264

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“…In recent years there have also been significant developments in the use of furocoumarins for the inactivation of viral, bacterial and protozoal pathogens in blood products [203][204][205], a property that would be useful for decontaminating human fluids prior to processing in the clinical laboratory. The most promising compounds for treating extracellular HIV by PUVA techniques are 4'-aminomethyl-polymethyl psoralens [206,207], psoralens that bear primary amino groups at the 3-, 4-, 5-or 8-positions [208], or psoralens with a substituent that is either a quaternary phosphonium or ammonium moiety and at least one substituent that is an halogen [209].…”

Section: E Biological Activity Of Furocoumarinsmentioning

confidence: 99%

Furocoumarins in Medicinal Chemistry. Synthesis, Natural Occurrence and Biological Activity

Santana

Uriarte

Roleira

et al. 2004

CMC

197

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The scope of this review encompasses the importance of furocoumarins and the most important developments in this field that have been made in recent years, with particular emphasis placed on the aspects related to medicinal chemistry. A concise and exhaustive overview is given regarding the methods used for the synthesis of these compounds, new furocoumarins isolated from natural sources, and the most significant biological properties associated with these molecules. The section describing the synthetic methods is organized on the basis of the key step used for the formation of the two different oxygenated rings. In this respect there are three possibilities: (i) formation of the furan ring onto the coumarin, (ii) formation of the pyrone ring onto the benzofuran and (iii) the simultaneous formation of both oxygenated rings onto a benzene unit. The most recent preparative approaches are discussed along with modifications or improvements to methods that, though not particularly new, are still commonly used. The recently discovered natural furocoumarins are focused and presented in tables that provide information about its structure and source. The discussion of the biological importance of furocoumarins mainly focuses on their more relevant applications in photochemotherapy, but also provides examples of their versatility in a range of applications in the fields of biology and pharmacology.

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2014

HIV and the Pathogenesis of AIDS

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Disinfection of cell-associated and extracellular HIV-1 by PUVA treatment

Cited by 3 publications

References 8 publications

Dependence of Human Stem Cell Engraftment and Repopulation of NOD/SCID Mice on CXCR4

Dependence of Human Stem Cell Engraftment and Repopulation of NOD/SCID Mice on CXCR4

Furocoumarins in Medicinal Chemistry. Synthesis, Natural Occurrence and Biological Activity

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