Dishevelled Associated Activator Of Morphogenesis (DAAM) Facilitates Invasion of Hepatocellular Carcinoma by Upregulating Hypoxia-Inducible Factor 1α (HIF-1α) Expression

Fang, Xiaoxu; Zhang, Dandan; Zhao, Weihua; Gao, Lei; Lan-ping, Wang

doi:10.12659/msm.924670

Cited by 6 publications

(7 citation statements)

References 26 publications

(30 reference statements)

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“…The role of DAAM2 in cancers has been preliminarily summarized. As previously described, DAAM2 accelerated the progression of glioma and hepatocellular carcinoma by facilitating the degradation of VHL (Zhu et al, 2017;Fang et al, 2020). In addition, DAAM2 is essential for the formation of actin-rich filopodia structures and then contributes to the increased capacity of migration and invasion (Lynch et al, 2013).…”

Section: Discussionmentioning

confidence: 65%

“…The results also revealed that DAAM2 was upregulated in PAAD tissues. The oncogenic role of DAAM2 has been confirmed in glioma and hepatocellular carcinoma ( Zhu et al, 2017 ; Fang et al, 2020 ), but the biological function of DAAM2 in PAAD needs to be further explored.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, several studies uncovered the direct connection between DAAM2 and hypoxia, a powerful regulatory factor for immunity. On the one hand, DAAM2 facilitated the degradation of VHL and upregulated HIF-1α expression ( Zhu et al, 2017 ; Fang et al, 2020 ); on the other hand, DAAM2 was upregulated by hypoxia in the circulation and placenta ( de Alwis et al, 2021 ). These findings suggest that Formin proteins, especially DAAM2, are associated with antitumor immunity in cancer.…”

Section: Discussionmentioning

confidence: 99%

“… Zhu et al (2017) reported that DAAM2 accelerated glioma formation by facilitating ubiquitination and degradation of Von Hippel-Landau (VHL) protein. In addition, DAAM2 promoted the progression of hepatocellular carcinoma by enhancing hypoxia-inducible factor 1α (HIF-1α) expression ( Fang et al, 2020 ). It has been widely proven that hypoxia is tightly associated with antitumor immunity in most cancer types ( Abou Khouzam et al, 2020 ; Fu et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

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Dishevelled-Associated Activator of Morphogenesis 2 (DAAM2) Predicts the Immuno-Hot Phenotype in Pancreatic Adenocarcinoma

Pan

Nie

Wang

et al. 2022

Front. Mol. Biosci.

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Background: DAAM2 participates in the oncogenesis and progression of human cancers. Although the role of DAAM2 in cancers has been preliminarily investigated, its correlations with antitumor immunity are unclear.Methods: A pancancer analysis was conducted to explore the immunological role of DAAM2 based on RNA sequencing (RNA-seq) data downloaded from The Cancer Genome Atlas (TCGA). Next, correlations between DAAM2 and immunological characteristics in the tumor microenvironment (TME) of pancreatic adenocarcinoma (PAAD) were evaluated. In addition, the role of DAAM2 in predicting the clinical characteristics and the response to various therapies in PAAD were also assessed. In addition, the correlations between DAAM2 and the emerging immunobiomarker N6-methyladenosine (m6A) genes were also evaluated.Results: Pancancer analysis revealed that DAAM2 exhibited positive correlations with a majority of immunomodulators, tumor-infiltrating immune cells (TIICs) and inhibitory immune checkpoints in several cancer types, including PAAD. In addition, DAAM2 was associated with an inflamed phenotype in the tumor microenvironment (TME). DAAM2 also predicted significantly higher responses to chemotherapy, anti-EGFR therapy and immunotherapy but lower responses to anti-ERBB2 and antiangiogenic therapy. In addition, DAAM2 was correlated with immune-related microbiota.Conclusion: In PAAD, DAAM2 is associated with an immuno-hot phenotype and can help predict the outcome of various therapeutic options. Overall, DAAM2 is a promising indicator for assessing high immunogenicity in PAAD.

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Section: Discussionmentioning

confidence: 65%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Dishevelled-Associated Activator of Morphogenesis 2 (DAAM2) Predicts the Immuno-Hot Phenotype in Pancreatic Adenocarcinoma

Pan

Nie

Wang

et al. 2022

Front. Mol. Biosci.

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“…Moreover, it has been shown that DAAM1 can help the migration and the invasion of cancerous cells. Also, it can promote tumor advancement in Hepatocellular Carcinoma as well as breast and ovarian cancers [33][34][35].…”

Section: Discussionmentioning

confidence: 99%

Exploration of mRNAs and miRNA classifiers for various ATLL cancer subtypes using machine learning

2022

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Background Adult T-cell Leukemia/Lymphoma (ATLL) is a cancer disease that is developed due to the infection by human T-cell leukemia virus type 1. It can be classified into four main subtypes including, acute, chronic, smoldering, and lymphoma. Despite the clinical manifestations, there are no reliable diagnostic biomarkers for the classification of these subtypes. Methods Herein, we employed a machine learning approach, namely, Support Vector Machine-Recursive Feature Elimination with Cross-Validation (SVM-RFECV) to classify the different ATLL subtypes from Asymptomatic Carriers (ACs). The expression values of multiple mRNAs and miRNAs were used as the features. Afterward, the reliable miRNA-mRNA interactions for each subtype were identified through exploring the experimentally validated-target genes of miRNAs. Results The results revealed that miR-21 and its interactions with DAAM1 and E2F2 in acute, SMAD7 in chronic, MYEF2 and PARP1 in smoldering subtypes could significantly classify the diverse subtypes. Conclusions Considering the high accuracy of the constructed model, the identified mRNAs and miRNA are proposed as the potential therapeutic targets and the prognostic biomarkers for various ATLL subtypes.

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Evidence for Admixture and Rapid Evolution During Glacial Climate Change in an Alpine Specialist

Weng,

Kavanaugh,

Schoville

2024

Molecular Biology and Evolution

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The pace of current climate change is expected to be problematic for alpine flora and fauna, as their adaptive capacity may be limited by small population size. Yet despite substantial genetic drift following post-glacial recolonization of alpine habitats, alpine species are notable for their success surviving in highly heterogeneous environments. Population genomic analyses demonstrating how alpine species have adapted to novel environments with limited genetic diversity remain rare, yet are important in understanding the potential for species to respond to contemporary climate change. In this study, we explored the evolutionary history of alpine ground beetles in the Nebria ingens complex, including the demographic and adaptive changes that followed the last glacier retreat. We first tested alternative models of evolutionary divergence in the species complex. Using millions of genome-wide SNP markers from hundreds of beetles, we found evidence that the Nebria ingens complex has been formed by past admixture of lineages responding to glacial cycles. Recolonization of alpine sites involved a distributional range shift to higher elevation, which was accompanied by a reduction in suitable habitat and the emergence of complex spatial genetic structure. We tested several possible genetic pathways involved in adaptation to heterogeneous local environments using genome scan and genotype-environment association approaches. From the identified genes, we found enriched functions associated with abiotic stress responses, with strong evidence for adaptation to hypoxia-related pathways. The results demonstrate that despite rapid demographic change, alpine beetles in the N. ingens complex underwent rapid physiological evolution.

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Dishevelled Associated Activator Of Morphogenesis (DAAM) Facilitates Invasion of Hepatocellular Carcinoma by Upregulating Hypoxia-Inducible Factor 1α (HIF-1α) Expression

Cited by 6 publications

References 26 publications

Dishevelled-Associated Activator of Morphogenesis 2 (DAAM2) Predicts the Immuno-Hot Phenotype in Pancreatic Adenocarcinoma

Dishevelled-Associated Activator of Morphogenesis 2 (DAAM2) Predicts the Immuno-Hot Phenotype in Pancreatic Adenocarcinoma

Exploration of mRNAs and miRNA classifiers for various ATLL cancer subtypes using machine learning

Evidence for Admixture and Rapid Evolution During Glacial Climate Change in an Alpine Specialist

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