Disfiguring burn scars and adolescent self-esteem

Robert, Rhonda; Meyer, Walter J.; Bishop, Sheryl; Rosenberg, Laura; Murphy, Linda; Blakeney, Patricia

doi:10.1016/s0305-4179(99)00065-0

Cited by 114 publications

(69 citation statements)

References 10 publications

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“…In a study of 14 adolescents (13-20 years old) at least 2 years after burn injuries, lower scores on athletic competence and physical appearance and higher scores on social acceptance and job competence were found [20]. The different findings between adolescents with burns compared with our investigated group adolescents with MSS can be explained by the fact that in the previously mentioned studies adolescents with scars were compared with normative adolescents, whereas in our study MSS adolescent with scars were compared with MSS adolescents without scars.…”

Section: Relationship Between Scars Amputations and Orthopedic Sequementioning

confidence: 96%

See 1 more Smart Citation

Self-Esteem in Children and Adolescents After Septic Shock Caused by Neisseria meningitidis: Scars Do Matter

Vermunt

Buysse

Joosten

et al. 2008

Journal of Adolescent Health

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Section: Relationship Between Scars Amputations and Orthopedic Sequementioning

confidence: 96%

“…Lower and higher outcomes of self-esteem were found in burn patients 1-17 years postburn [19,20]. In almost all studies cited above the Harter Self-Perception Profiles for Children (SPP-C) [21] and/or the Harter Self-Perception Profiles for Adolescents (SPP-A) [7] were used (with few exceptions [14,17]).…”

mentioning

confidence: 99%

Self-Esteem in Children and Adolescents After Septic Shock Caused by Neisseria meningitidis: Scars Do Matter

Vermunt

Buysse

Joosten

et al. 2008

Journal of Adolescent Health

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“…Children are particularly affected and can suffer from long-term physical dysfunction 1,2 and psychological harm [3][4][5] from the scars that result from major burns and surgery. In the United States, 500,000 patients per year are treated for burns, many of which leave scars and painful contractures that require major surgery.…”

Section: Overview Biomedical and Societal Burden Of Scarsmentioning

confidence: 99%

Cutaneous Scarring: Basic Science, Current Treatments, and Future Directions

Marshall

Leavitt

et al. 2018

Advances in Wound Care

222

176

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Significance: Scarring of the skin from burns, surgery, and injury constitutes a major burden on the healthcare system. Patients affected by major scars, particularly children, suffer from long-term functional and psychological problems. Recent Advances: Scarring in humans is the end result of the wound healing process, which has evolved to rapidly repair injuries. Wound healing and scar formation are well described on the cellular and molecular levels, but truly effective molecular or cell-based antiscarring treatments still do not exist. Recent discoveries have clarified the role of skin stem cells and fibroblasts in the regeneration of injuries and formation of scar. Critical Issues: It will be important to show that new advances in the stem cell and fibroblast biology of scarring can be translated into therapies that prevent and reduce scarring in humans without major side effects. Future Directions: Novel therapies involving the use of purified human cells as well as agents that target specific cells and modulate the immune response to injury are currently undergoing testing. In the basic science realm, researchers continue to refine our understanding of the role that particular cell types play in the development of scar. SCOPE AND SIGNIFICANCEThis review begins with an overview of how human skin wounds heal, with an emphasis on the formation of scar as the end result of wound healing. This is followed by a review of recent developments in the cellular biology of wound healing and scarring, particularly related to stem cells and fibroblasts. Finally, traditional and novel treatments intended to prevent and reduce scarring are described. This review will be of interest to clinicians and basic scientists who wish to better understand the processes of wound healing and scarring as well as the treatment options available. TRANSLATIONAL RELEVANCEA great deal has been learned about the cellular and molecular pathways that contribute to scar formation. At the same time, clinicians have understood for centuries that certain techniques allow wounds to heal faster with less scarring. Despite the enormity of the clinical problem presented by scarring, there has been a failure to translate the basic science of scarring into improved scarring treatments that take advantage of specific molecular and cellular targets. However, in the field, there is optimism that recent advances will bridge the gap between the basic science and the clinical treatment of scarring. CLINICAL RELEVANCE Scarring of the skin affects millions of patients and in some, particularly children and burn victims, causes a great deal of suffering. Scar prevention mainly consists of the principles of wound closure without tension and avoiding infection and wound breakdown. Various treatments for established scars exist, with varying levels of effectiveness. Burn scars are particularly challenging, and treatment is largely supportive with the option for revision surgery to remove scarred skin. A novel drug-based treatment that makes use of a specific mole...

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“…if fetal scarless wounds represent one end of the tissue repair spectrum, keloids represent the other end. in addition to the considerable functional loss and unwanted cosmetic result, keloids can cause psychosocial effects including a loss of self esteem, as well as social stigmatisation leading to a dimished quality of life (1,2). The prevention and treatment of keloids are particularly characterised by downright polypragmacy, leading to an elevated rate of recurrence.…”

Section: Introductionmentioning

confidence: 99%

Keloids: Fundamental principles and prospects (Review)

Gieringer

Elliott²,

Gosepath³

et al. 2009

Mol Med Rep

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Abstract. Wound healing is a very complex process of interactions between different cells, growth factors, blood elements and extracellular matrix. Keloids represent one of the possible complications in the fundamental process of cutaneous wound repair. despite all efforts, keloids remain a therapeutic challenge since no treatment is as yet considered 100% effective. Growth factors, discovered in the late 1970s, have been shown to influence dermal regeneration. However, the exogenous application of growth factors to chronic wounds has not proven to be effective in healing them. additionally, genetic analysis has not revealed any single gene that might cause keloids; as such, classic gene therapy is not a feasible option for the treatment of keloids. a new approach is so-called somatic gene therapy. This review provides an overview of the fundamentals of wound healing and of keloids, and presents new possibilities that may improve cutaneous wound repair.

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Disfiguring burn scars and adolescent self-esteem

Cited by 114 publications

References 10 publications

Self-Esteem in Children and Adolescents After Septic Shock Caused by Neisseria meningitidis: Scars Do Matter

Self-Esteem in Children and Adolescents After Septic Shock Caused by Neisseria meningitidis: Scars Do Matter

Cutaneous Scarring: Basic Science, Current Treatments, and Future Directions

Keloids: Fundamental principles and prospects (Review)

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