Disentangling the complexity of psoriasis in the post-genome-wide association era

Antonatos, Charalabos; Grafanaki, Katerina; Georgiou, Sophia; Evangelou, Evangelos; Vasilopoulos, Yiannis

doi:10.1038/s41435-023-00222-x

Genes Immun

2023

DOI: 10.1038/s41435-023-00222-x

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Disentangling the complexity of psoriasis in the post-genome-wide association era

Charalabos Antonatos,

Katerina Grafanaki,

Sophia Georgiou

et al.

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2024

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References 137 publications

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Transcriptomic meta-analysis characterizes molecular commonalities between psoriasis and obesity

Antonatos,

Georgakilas,

Evangelou

et al. 2024

Genes Immun

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Despite the abundance of epidemiological evidence for the high comorbid rate between psoriasis and obesity, systematic approaches on common in ammatory mechanisms have not been adequately explored. We performed a meta-analysis of publicly available RNA-sequencing datasets to unveil putative mechanisms that are postulated to exacerbate both diseases, utilizing both late-stage, disease-speci c meta-analyses and consensus gene co-expression network (cWGCNA). Single-gene meta-analyses reported several common in ammatory mechanisms fostered by the perturbed expression pro le of pathogenic cell types. Assessment of gene overlaps between both diseases revealed signi cant overlaps between up-(n = 170, P-value = 6.07×10 -65 ) and down-regulated (n = 49, P-value = 7.1×10 − 7 ) genes, associated with increased T cell response and activated transcription factors. Our cWGCNA approach disentangled 48 consensus modules, associated with either the differentiation of leukocytes or metabolic pathways with similar correlation signals in both diseases. Notably, all our analyses con rmed the association of the perturbed T helper (Th)17 differentiation pathway in both diseases. Our novel ndings through whole transcriptomic analyses characterize the in ammatory commonalities between psoriasis and obesity implying the assessment of several expression pro les that could serve as putative comorbid disease progression biomarkers and therapeutic interventions.

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Transcriptomic meta-analysis characterizes molecular commonalities between psoriasis and obesity

Antonatos,

Georgakilas,

Evangelou

et al. 2024

Genes Immun

Self Cite

View full text Add to dashboard Cite

show abstract

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Disentangling the complexity of psoriasis in the post-genome-wide association era

Cited by 1 publication

References 137 publications

Transcriptomic meta-analysis characterizes molecular commonalities between psoriasis and obesity

Transcriptomic meta-analysis characterizes molecular commonalities between psoriasis and obesity

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