Disentangling the associations between past childhood adversity and psychopathology during the COVID-19 pandemic: The mediating roles of specific pandemic stressors and coping strategies

Jernslett, Maria; Anastassiou‐Hadjicharalambous, Xenia; Lioupi, Chrysanthi; Syros, Ioannis; Kapatais, Alexandros; Karamanoli, Vassia; Evgeniou, Eleftheria; Messas, Kostas; Palaiokosta, Triada; Papathanasiou, Eleni; Lotzin, Annett

doi:10.1016/j.chiabu.2022.105673

Cited by 6 publications

(4 citation statements)

References 49 publications

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“…In turn, mental disorder worsens economic outcomes, for example, through lower work productivity. Jernslett and colleagues (2022) found an association between difficult housing conditions and depression, which might be mediated by low income. In sum, public health crises, such as the COVID-19 pandemic, tend to disproportionately affect those people living in poverty ( Ridley et al, 2020 ).…”

Section: Discussionmentioning

confidence: 92%

Profiles of risk factors for depressive and anxiety symptoms during the COVID-19 pandemic: A latent class analysis

Kenntemich

Hülsen

Schäfer

et al. 2023

Psychiatry Research

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Section: Discussionmentioning

confidence: 92%

Profiles of risk factors for depressive and anxiety symptoms during the COVID-19 pandemic: A latent class analysis

Kenntemich

Hülsen

Schäfer

et al. 2023

Psychiatry Research

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“…This study is part of the longitudinal CONNECT study conducted in the Netherlands, examining the impact of the COVID-19 pandemic on mental health outcomes in Dutch people (Lenferink et al, 2022a). The CONNECT study is part of a pan-European research collaboration coordinated by the European Society for Traumatic Stress Studies conducted in eleven European countries including Austria, Croatia, Georgia, Germany, Greece, Italy, Lithuania, Poland, Portugal, Sweden, and the Netherlands (the ADJUST study; Ajduković et al, 2022;Eklund et al, 2022;Gelezelyte et al, 2021;Jernslett et al, 2022;Kenntemich et al, 2022;Lenferink et al, 2022a;Lotzin et al, 2020;Lotzin et al, 2021Lotzin et al, , 2022aLotzin et al, , 2022bLotzin et al, , 2022cLueger-Schuster et al, 2022;Meyer et al, 2022;Zrnić Novaković et al, 2022). The main aim of the ADJUST study is to examine the psychological impact of the COVID-19 pandemic on mental health in the general European population using a psychotrauma lens.…”

Section: Designmentioning

confidence: 99%

Trajectories of DSM-5-TR Prolonged Grief Disorder Severity in the First Two Years After Loss During the COVID-19 Pandemic

Reitsma,

Mooren,

Mouthaan

et al. 2024

Preprint

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Due to the presumed high risk for prolonged grief disorder (PGD) in people bereaved during the COVID-19 pandemic, it is crucial to examine how grief develops over time in this population. This is the first study examining longitudinal symptom-profiles of PGD severity in people bereaved during the pandemic. We aimed to identify latent trajectories of DSM-5-TR PGD severity and predictors thereof in Dutch adults bereaved during the pandemic. Latent class growth modeling was employed to identify differential trajectories of PGD severity in 266 people bereaved on average 115 days prior when entering the study. Participants completed a PGD measure online (using the Traumatic Grief Inventory-Self Report-Plus) at three time-intervals six months apart. Associations between class-membership and socio-demographic, loss-related, health-related, and trauma-related characteristics were examined using multinomial logistic regression. Three trajectories were identified: Low/decreasing PGD symptoms (74%), Mild/stable PGD symptoms (18%), and High/decreasing PGD trajectory (8%). Closer kinship to the deceased, poorer self-rated health status, and having a mental disorder increased the likelihood of belonging to the Mild/stable PGD symptoms and High/decreasing PGD trajectories. This study provides insights in longitudinal PGD symptom-profiles in people bereaved during the pandemic. We found that PGD severity either remained low/mild or eventually decreased over time.

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“…Children are now more susceptible to psychological and social stress due to various behavioral restrictions in foster care environments. One factor that predisposes individuals to heightened psychological vulnerability during the COVID-19 pandemic is past exposure to adverse childhood experiences [130]. Children are susceptible to psychological and social stress in various situations due to various behavioral restrictions imposed by the COVID-19 pandemic.…”

Section: The Coronavirus Disease Increases Mental Illness and Chronic...mentioning

confidence: 99%

“…It may also increase the risk of child abuse. Therefore, a dramatic increase in the number of patients with mental disorders is expected in the future [130][131][132]. Even before the COVID-19 pandemic, it was reported that children who had grown up in an unfavorable nurturing environment were more vulnerable to depression, which became more pronounced during the COVID-19 pandemic [133].…”

Section: The Coronavirus Disease Increases Mental Illness and Chronic...mentioning

confidence: 99%

Stress-Induced Changes in the Endogenous Opioid System Cause Dysfunction of Pain and Emotion Regulation

Nakamoto

Tokuyama

2023

IJMS

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Early life stress, such as child abuse and neglect, and psychosocial stress in adulthood are risk factors for psychiatric disorders, including depression and anxiety. Furthermore, exposure to these stresses affects the sensitivity to pain stimuli and is associated with the development of chronic pain. However, the mechanisms underlying the pathogenesis of stress-induced depression, anxiety, and pain control remain unclear. Endogenous opioid signaling is reportedly associated with analgesia, reward, addiction, and the regulation of stress responses and anxiety. Stress alters the expression of various opioid receptors in the central nervous system and sensitivity to opioid receptor agonists and antagonists. μ-opioid receptor-deficient mice exhibit attachment disorders and autism-like behavioral expression patterns, while those with δ-opioid receptor deficiency exhibit anxiety-like behavior. In contrast, deficiency and antagonists of the κ-opioid receptor suppress the stress response. These findings strongly suggest that the expression and dysfunction of the endogenous opioid signaling pathways are involved in the pathogenesis of stress-induced psychiatric disorders and chronic pain. In this review, we summarize the latest basic and clinical research studies on the effects of endogenous opioid signaling on early-life stress, psychosocial stress-induced psychiatric disorders, and chronic pain.

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Disentangling the associations between past childhood adversity and psychopathology during the COVID-19 pandemic: The mediating roles of specific pandemic stressors and coping strategies

Cited by 6 publications

References 49 publications

Profiles of risk factors for depressive and anxiety symptoms during the COVID-19 pandemic: A latent class analysis

Profiles of risk factors for depressive and anxiety symptoms during the COVID-19 pandemic: A latent class analysis

Trajectories of DSM-5-TR Prolonged Grief Disorder Severity in the First Two Years After Loss During the COVID-19 Pandemic

Stress-Induced Changes in the Endogenous Opioid System Cause Dysfunction of Pain and Emotion Regulation

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