Disentangling neurodegeneration from ageing in multiple sclerosis: the brain-predicted disease duration gap
Giuseppe Pontillo,
Ferran Prados,
Jordan Colman
et al.
Abstract:Disentangling brain ageing from disease-related neurodegeneration in patients with multiple sclerosis (PwMS) is increasingly topical. The brain-age paradigm offers a window into this problem but may miss disease-specific effects. Here, we statistically modelled disease duration (DD) in PwMS as a function of brain MRI scans and evaluated whether the brain-predicted DD gap (i.e., the difference between predicted and actual duration) could complement the brain-age gap as a DD-adjusted global measure of multiple s… Show more
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