Diseases of the thyroid gland and the hypothalamo-pituitary-thyroid axis.

Bertin, Francois-Rene; Fraser, Natalie S.

doi:10.1079/9781789241099.0016

Cited by 1 publication

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“…The hypothalamic secretion TSH and pituitary secretion of TRH are under negative feedback control of free T4 and free T3. 6 Once the thyroid hormones are secreted into the blood, most of T3 and T4 binds with plasma proteins namely, thyroxinebinding globulin and thyroxinebinding prealbumin and albumin. T4 mainly binds with thyroxinebinding globulin whereas T3 binds mainly with albumin.…”

Section: Physiology Of Thyroid Hormonesmentioning

confidence: 99%

“…In circulation bound forms are in equilibrium with free forms. 6,7 In non thyroid illness, fall in serum T3 level (both total and free T3) along with raise in reverse T3 is seen. As disease progresses, fall in serum total T4 is also seen, a condition called 'low T3 T4 State'.…”

Section: Physiology Of Thyroid Hormonesmentioning

confidence: 99%

“…In spite of diverse etiologies, CKD is the final common pathway of irreversible loss of nephrons finally resulting in alteration of "milieu interior" affecting every system in the body including thyroid hormonal system. The functions of thyroid and kidney are interrelated [3][4][5][6] . The thyroid hormones are essential for growth and development of the kidney and for maintaining electrolyte and water homeostasis.…”

Section: Introductionmentioning

confidence: 99%

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Biochemical Assessments of Thyroid Profile and Renal Function Test in Chronic Kidney Disease

Shrivastava¹,

Khare²

2023

ijcsrr

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Introduction: CKD is a clinical syndrome which occurs due to irreversible loss of renal function leading to metabolic, endocrine, excretory and synthetic function resulting in accumulation of non – protein nitrogenous substances which leads to metabolic derangements and ends up with distinct clinical manifestations. Aim: To study thyroid function abnormalities in patients with chronic kidney disease. To correlate the thyroid function abnormalities with severity of renal failure. To differentiate primary hypothyroidism from thyroid dysfunction due to chronic kidney disease. Methodology: After selection of patients, fulfilling the above criteria, about 5 ml of blood sample is collected in non-heparinised serum bottle and sent for thyroid profile test. Components of thyroid profile included in our study and Quantitative determination of T3, T4 and TSH is done by Enzyme Linked Immunosorbent Assay. Result: In our study out of 50 patients, 33 patients had low serum T3 levels . 4 patients among low serum T3 value, they also had low T4 and high TSH suggesting primary hypothyroidism. So excluding 4 patients of hypothyroidism 29 patients had low T3 syndrome in our study. Low T4 levels in our study, out of which 4 patients had low T3 and high TSH suggesting primary hypothyroidism. Conclusion: In my study population, 50 CKD patients who were on conservative management were studied. Among them 66% of the patients had low T3 values. The change in the serum levels of T3 and T4 in patients with CKD can be considered as being protective, promoting conservation of protein. There is increase in incidence of hypothyroidism in patients with chronic kidney disease.

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Section: Physiology Of Thyroid Hormonesmentioning

confidence: 99%

Section: Physiology Of Thyroid Hormonesmentioning

confidence: 99%