Diseases of the Skin in Pregnancy

Crawford, G. Marshall

doi:10.1001/archderm.1950.01530120044004

Cited by 30 publications

(2 citation statements)

References 3 publications

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Clinical evidences indicate th at endocrine factors especially the sex hormones m ay play an essential role in the course of psoriasis, and perhaps, in its pathogenesis.Such data have been reported by past (cited by Margarot, Mayr) as well as contem porary authors (Lane and Cranford 1937, Cuno 1938, Madden 1939, Crawford and Leeper 1950, Barber 1950, Griineberg 1952, Nardelli 1957, Church 1958, Lomholl 1963.lloede (1957), in an article on the problem of heredity of psoriasisin which a great num ber of cases of psoriasis (2717) are reviewedstates th at the dependence of the fluctuations of manifestations of psoriasis from the physiologic function of sex hormones is easy to be proved statistically; this being more evident in the female. It is notable to mention here th at in Hoede's statistics, among 1285 psoriatic women, the onset of the disease occurred at the age of 10 to 29 years in 65 %^14,5 % in the age group of 10 to 19 and 20.5 % in the age group of 20 to 29 years.

The age period of 10 to 29 in women suggest the most flourishing phase of sex hormonal activity during which the onset of psoriasis more often takes place.

At the present time though during the last decades a considerable progress has been made in the understanding of the local histo logical, histochemical and biochemical processes of the disease, psoria sis still remains as Scott (I960) puts it " a fascinating enigma in Derma tology" .

The purpose of this paper is to report the findings on the cellular composition of vaginal smears in a number of psoriatic women and to discuss their relation to the obscure problem of the pathogenesis of psoriasis.

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supporting

confidence: 81%

Vaginal Cytology in Psoriatic Women

Papamiltiades¹,

Belezos²

1968

Dermatology

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“…

The age period of 10 to 29 in women suggest the most flourishing phase of sex hormonal activity during which the onset of psoriasis more often takes place.

…”

supporting

confidence: 81%

Vaginal Cytology in Psoriatic Women

Papamiltiades¹,

Belezos²

1968

Dermatology

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“…In general, it appears that in systemic lupus erythematosus there is an increase in the abortion, stillbirth, and prematurity rates (Crawford and Leeper, 1950;Ellis and Bereston, 1952;Friedman and Rutherford, 1956;Murray, 1958;Madsen and Anderson, 1961;Garsenstein, Pollak, and Kark, 1962;Mund, Simpson, and Rothfield, 1963). The prognosis is worse if the mother has an exacerbation of the disease in early pregnancy.…”

Section: Discussionmentioning

confidence: 99%

Congenital heart block and widespread fibrosis due to maternal lupus erythematosus.

Hull¹,

Binns²,

Joyce³

1966

Archives of Disease in Childhood

116

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We here report the clinical and pathological findings of a newborn infant with complete heart block who died 25 minutes after birth. Extensive fibrosis was found in many organs, including the heart, liver, and kidneys. The mother suffered from systemic lupus erythematosus and it seems probable that the maternal disease was responsible for the infant's condition. Case ReportMaternal history. In 1949 the mother (age 22) developed the characteristic cutaneous rash of lupus erythematosus. The clinical diagnosis was supported by the histological appearance of a skin biopsy. The erythrocyte sedimentation rate ranged between 68-100 mm./hr., and the white cell count between 3000-4000/ c.mm. Since that time her general health has been good, the skin lesions have varied in severity, and the leucopenia and high sedimentation rate have persisted. LE cells were not found in the peripheral blood, and the Wassermann reaction was negative. Her blood group was 0 Rh positive.Previous pregnancies. In 1947 her first child was born at 34 weeks' gestation after surgical induction (male, birthweight 2-3 kg.). In 1953 her second child was born at term (female, 2 * 8 kg.). The delivery and subsequent development of both infants were normal. In 1957 her third child was born by spontaneous vertex delivery at term (female, 2-8 kg.). At birth the baby had a rash on the face and scalp, which was characteristic of chronic discoid lupus erythematosus. The rash cleared spontaneously over the next few months. Present pregnancy. In December 1962 the mother (age 37) became pregnant for the fourth time. During the first three months of the pregnancy she took chloroquine 250 mg. once or twice each day because of an exacerbation of the skin lesions. At 36 weeks' gestation it was noted that the foetal heart rate was slow but regular. The bradycardia persisted and a clinical diagnosis was made of intrauterine heart block. This was confirmed by foetal ECG which showed the rate to be 45 beats/minute. Received March 8, 1966. Delivery. Labour commenced at 38 weeks' gestation after spontaneous rupture of the membranes. There was moderate hydramnios and the liquor was stained with meconium. The labour lasted 3j hours. When the cervix was fully dilated, the head was rotated by hand from the occipito-posterior position and delivered after an easy pull with Wrigley's forceps.Infant. The infant (male, 2 * 5 kg.) had gross oedema of the head and trunk. In contrast the abdomen and limbs were not swollen. There were numerous purple patches on the face, scalp, and upper chest, which were similar to blotch haemorrhages commonly seen in newborn infants with severe anaemia, and the liver and spleen were both enlarged (3-4 cm. below the costal margin). The scrotum was darkly pigmented.At birth, the infant had normal muscle tone and reflex irritability and, though he did not gasp or cry, he immediately began regular respiratory movements. The ECG showed complete heart block, atrial rate 168 beats/ min., and ventricular rate 45 beats/min. (Fig.). His chest, which initi...

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Progesterone Therapy in Dermatoses of Pregnancy (Herpes Gestationis)

Keaty¹

1951

Arch Dermatol

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Diseases of the Skin in Pregnancy

Cited by 30 publications

References 3 publications

Vaginal Cytology in Psoriatic Women

Vaginal Cytology in Psoriatic Women

Congenital heart block and widespread fibrosis due to maternal lupus erythematosus.

Progesterone Therapy in Dermatoses of Pregnancy (Herpes Gestationis)

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